BALTIMORE--(BUSINESS WIRE)--May 30, 2025--
For the 73 rd Conference on Mass Spectrometry and Allied Topics (ASMS), Bruker Corporation (Nasdaq: BRKR) announced the launch of the timsOmni™ system, a transformative new timsTOF-based mass spectrometer designed for scientific, drug discovery, and clinical researchers, as well as for advanced QC on biologics, offering deep structural insights into the functional or pathological proteoforms or oligonucleotides. Multimodal eXd trapping with precise electron energy control, ion accumulation, and reaction time regulation is a cornerstone innovation of the timsOmni™ platform. This also enables CIU, further expanding the value of proteoform CCS information, followed by multiple electron-based (ECD, EID) and collision-based (CID) fragmentation techniques. The timsOmni uniquely enables protein researchers and biologics developers to tailor information-rich dissociation pathways for deeper insights - with high speed and high sensitivity.
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timsOmni™ Mass Spectrometer
timsOmni™ Mass Spectrometer
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The ‘Swiss-army knife’ type flexibility of the timsOmni top-down capability enables the identification of low-abundant, aberrant proteoforms, the structurally altered versions of proteins arising from genetic mutations, alternative splicing, or post-translational modifications that deviate from normal physiological forms, disrupting protein function, misfolding, or aggregation, and often play critical roles in the onset and progression of human diseases, including cancer, neurodegeneration, cardiovascular disorders, and autoimmune conditions.
Anders Giessing, PhD, Science Manager at Novonesis in Denmark, said, “We use intact protein mass analysis to ensure performance, stability, and consistency of our diverse protein product portfolio. Introduction of the timsOmni, with its Swiss Army knife versatility, redefines intact mass and top-down analysis with the precision, speed, and confidence needed to provide definitive analytical support in the development and production of industrial enzymes.”
The Omnitrap’s signature high-sensitivity, high-speed, multimodal eXd capability is particularly powerful for mapping PTMs, such as histone proteoforms (H3:1K14ac) that play a crucial role in regulating gene expression by altering chromatin structure and controlling access to the DNA. Other PTMs like glycosylation critically influence protein folding, stability, transport, and cell signaling interactions, and detailed top-down or middle-down sequencing of complementarity-determining regions (CDRs) in humoral and therapeutic antibodies are important in cancer, autoimmunity and biologics development.
Prof. Albert Heck, Professor of Chemistry and Pharmaceutical Sciences at Utrecht University and Scientific Director of the Netherlands Proteomics Center, commented, “Proteomics will finally go ‘protein-centric’ by using the timsOmni. The multimodal eXd capability allows for comprehensive ion sequence ladders that are ideal for de novo sequencing and human plasma antibody repertoire profiling. Analyzing and monitoring circulating antibody levels is critical for characterizing the progression of a disease, identifying patients with delayed symptom onset, and predicting potential long-term immunity.”
Frank H. Laukien, Ph.D., the CEO of Bruker Corporation, added, “The timsOmni is a new lamppost for functional protein science, shining a light on functional and pathological proteoforms and truly enabling a new protein science paradigm for fundamental cell and molecular biology, signal transduction, cancer, neurodegeneration, and other disease research. The timsOmni will also be extremely valuable for biopharma drug discovery and development, as well as for biologics QC analysis, from therapeutic antibodies to antibody-drug conjugates.”
The timsOmni is supported by OmniScape™, Bruker’s next-generation top-down proteomics software that features state-of-the-art algorithms for de-isotoping complex spectra, automated charge state assignment, de novo protein sequencing support, and sequence confirmation. These key features provide unrivaled benefits for the accurate identification of proteoforms, post-translational modifications, and non-canonical proteins. OmniScape transforms complex eXd fragmentation spectra into actionable biological insights—empowering researchers to navigate the new world of functional proteoformics.
Prof. Ole N. Jensen, Group Leader at the Protein Research Group of the University of Southern Denmark, observed, “The timsOmni technology and OmniScape software already impacted our strategies for intact protein and proteoform analysis. Multimodal MS/MS fragmentation and MS3 afford very high amino acid sequence coverage and accurate localization of post-translational modifications in histones.”
The timsOmni comes with the new NEOS off-line nanoESI for the extremely low infusion flow rates required for the study of protein complexes, allowing for extended analysis of scarce samples. The NEOS source works with coated and non-coated emitters. Additionally, the timsOmni retains the high sensitivity of the timsTOF Ultra 2 for nLC dia-PASEF high-throughput bottom-up 4D-proteomics.
The timsOmni ushers in a new era of functional proteomics, setting the stage for landmark discoveries in ‘ Proteoformics ’, and advancing a transformative new paradigm in protein research as it illuminates protein function through the deep sequencing of proteoforms, humoral and multi-specific antibodies, and other complex biomolecules.
About Bruker Corporation – Leader of the Post-Genomic Era (Nasdaq: BRKR)
Bruker is enabling scientists and engineers to make breakthrough post-genomic discoveries and develop new applications that improve the quality of human life. Bruker’s high performance scientific instruments and high value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular, and microscopic levels. In close cooperation with our customers, Bruker is enabling innovation, improved productivity, and customer success in post-genomic life science molecular and cell biology research, in applied and biopharma applications, in microscopy and nanoanalysis, as well as in industrial and cleantech research, and next-gen semiconductor metrology in support of AI. Bruker offers differentiated, high-value life science and diagnostics systems and solutions in preclinical imaging, clinical phenomics research, proteomics and multiomics, spatial and single-cell biology, functional structural and condensate biology, as well as in clinical microbiology and molecular diagnostics. For more information, please visit www.bruker.com.
timsOmni™ Mass Spectrometer
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Inside the timsOmni™
timsOmni™ Mass Spectrometer
LONDON (AP) — British Prime Minister Keir Starmer pledged to revive his struggling government but faced growing calls to resign after a disastrous set of local and regional elections for his Labour Party.
As the final results came in Saturday, Labour suffered a net loss of more than 1,100 local council seats across England, lost control of several local authorities it had held for decades and was booted from power in Wales after 27 years. Anti-immigration party Reform UK gained over 1,300 seats across England and made significant gains in legislative elections in Wales and Scotland.
It was a blunt verdict from voters in elections widely seen as an unofficial referendum on Starmer, whose popularity has plummeted since he led the center-left party to power less than two years ago.
Here are five things we’ve learned from the elections.
Starmer insisted he would not walk away and "plunge the country into chaos,” and the dire election results did not produce an immediate challenge to his leadership.
"The right thing to do is rebuild and show the path forward,” Starmer said Saturday. “That’s what I’m going to do in the coming days.”
Starmer’s Cabinet colleagues expressed support, and none of the high-profile Labour politicians considered potential challengers has made a move. Health Secretary Wes Streeting, former Deputy Prime Minister Angela Rayner and Greater Manchester Mayor Andy Burnham are keeping quiet for now.
But a growing number of Labour lawmakers urged the prime minister to set a timetable for his departure this year. British politics allows parties to change leader midterm without the need for a new election.
“There has to be a timetable,” legislator Clive Betts told the BBC. Another lawmaker, Tony Vaughan, said there should be an “orderly transition of leadership.”
Starmer tried to demonstrate change on Saturday by bringing back two figures from past Labour governments. He made former Prime Minister Gordon Brown a special envoy on global finance, and appointed the party's ex-deputy leader Harriet Harman an adviser on women and girls.
Starmer is due to make a speech on Monday in an attempt to regain momentum, before the government sets out its legislative plans on Wednesday in a speech delivered by King Charles III at the State Opening of Parliament.
The elections were a breakthrough for Reform UK, the latest hard-right party led by the veteran nationalist politician Nigel Farage.
Running on an anti-establishment and anti-immigration message, the party won hundreds of local council seats in working-class areas in England’s north, such as Sunderland, that were solid Labour turf for decades. It also made gains from the Conservatives in areas like the county of Essex, east of London, and increased its vote share in Wales and Scotland, new terrain for the party.
Farage said the results marked a “historic change in British politics.” He said he's confident that “voters who have come to us are not doing it as a short-term protest.”
Reform UK currently holds just eight of the 650 seats in the House of Commons and it’s unclear whether it could repeat its success in a national election.
The elections produced semiautonomous administrations in Scotland and Wales led by parties devoted to independence and the breakup of the United Kingdom — though neither has that policy on the front burner.
The Scottish National Party, which has governed in Edinburgh since 2007, won another term but fell short of a majority, meaning an independence referendum is unlikely. Labour and Reform tied in a distant second place.
Plaid Cymru (The Party of Wales) won the most seats in the Cardiff-based legislature, the Senedd. The party, which has an ambition for Wales to leave the U.K. but no plan to do so anytime soon, fell short of a majority but will likely form the new government. Reform came second and Labour a distant third in one of its most historic heartlands, with outgoing First Minister Eluned Morgan losing her seat.
The economy lies at the heart of Labour’s troubles, as it does for many incumbent governments.
Since ending 14 years of Conservative rule roiled by austerity and the COVID-19 pandemic, Labour has struggled to ease the cost of living and jump-start a sluggish economy against the tough economic backdrop of war in Ukraine and, more recently, Iran. Starmer also has angered supporters with attempts to cut welfare spending, some of which were reversed after Labour revolts.
Some in Labour say the government's achievements, including protections for renters and a higher minimum wage, are going unnoticed. Many blame Starmer, an uninspiring leader distracted by scandals including his disastrous decision to appoint Peter Mandelson, a scandal-tarnished friend of Jeffrey Epstein, as Britain’s ambassador to Washington.
But Stephen Houghton, the outgoing leader of Barnsley council in northern England, where Labour lost to Reform, said the problem “goes deeper than the prime minister.”
“This has been coming for 30 years around the country, in post-industrial communities, coastal communities, that have been left behind,” he said. “You can change prime ministers all day long. If you don’t change policy, it’s not going to change.”
The results reflect a fragmentation of U.K. politics after decades of domination by Labour and the Conservative Party, which also suffered major losses on Thursday.
The elections offered voters a rainbow of choices, including the centrist Liberal Democrats and the nationalist parties in Scotland and Wales.
But the big winners were populist insurgents, Reform UK and the Green Party, whose focus has expanded from the environment to social justice and the Palestinian cause under self-described “eco populist” leader Zack Polanski. The Greens won hundreds of council seats from Labour in urban centers and university towns and took control of several local authorities.
Tony Travers, professor of government at the London School of Economics, said the results suggest the next national election, due by 2029, won’t produce a majority for any party.
“So then you’re in the world of, after the election, two or three big minority parties trying to work out how they would govern,” he said — something traditionally considered “very un-British.”
British Prime Minister Sir Keir Starmer speaking to the media after meeting Labour Party members during a visit to AFC Wimbledon in south London, Saturday May 9, 2026. (Maja Smiejkowska/PA via AP)
First Minister and SNP leader John Swinney with some of the newly elected SNP MSPs in Edinburgh, Saturday May 9, 2026, following the 2026 Holyrood elections. (Jane Barlow/PA via AP)
British Prime Minister Sir Keir Starmer and Foreign Secretary David Lammy meeting Labour Party members during a visit to AFC Wimbledon in south London, Saturday May 9, 2026. (Maja Smiejkowska/PA via AP)
British Prime Minister Sir Keir Starmer speaking to the media after meeting Labour Party members during a visit to AFC Wimbledon in south London, Saturday May 9, 2026. (Maja Smiejkowska/PA via AP)
Observers from the Scottish National Party (SNP) watch as votes are counted for the 2026 Holyrood elections, at Dewars Centre in Perth, Scotland, Friday May 8, 2026. (Jane Barlow/PA via AP)
Reform UK leader Nigel Farage speaks to supporters at Chelmsford City Racecourse, Friday May 8, 2026, in Essex, England, following the 2026 local election results. (Jordan Pettitt/PA via AP)
Britain's Prime Minister Sir Keir Starmer speaks to Labour Party members at Kingsdown Methodist Church Hall, in Ealing, west London, Friday May 8, 2026, a day after the local elections. (Stefan Rousseau/PA via AP)
