49ers look to improve to 4-0 when they host the Jaguars without Nick Bosa

Jacksonville (2-1) at San Francisco (3-0)

Sunday, 4:05 p.m. EDT, Fox.

BetMGM NFL Odds: 49ers by 3.

Against the spread: Jaguars 2-1; 49ers 2-1.

Series record: 49ers lead 5-2.

Last week: Jaguars beat Texans 17-10; 49ers beat Cardinals 16-15.

Last meeting: 49ers beat Jaguars 34-3 at Jacksonville, Fla., Nov. 12, 2023.

Jaguars offense: overall (8), rush (5), pass (13), scoring (14).

Jaguars defense: overall (10), rush (5), pass (16), scoring (5).

49ers offense: overall (7), rush (26), pass (1), scoring (23).

49erss defense: overall (4), rush (15), pass (5), scoring (3).

Turnover differential: Jaguars plus-5; 49ers minus-1.

WR Brian Thomas Jr. The second-year pro has dropped six passes in three games, including three last week against Houston. All three came on third down plays that halted drives. Thomas rebounded with a 46-yarder to set up the winning score. But it did little to ease concern about his early season woes. He dropped two passes in Week 2, including one on fourth down near the goal line.

DE Mykel Williams. With Nick Bosa out for the season with a knee injury, the Niners will be counting heavily on their first-round rookie. Williams has been stout against the run so far this season and had a team-high six QB pressures last week, according to Pro Football Focus.

Jaguars DE Josh Hines-Allen vs. 49ers LT Trent Williams. Hines-Allen ranks second in the league with 18 QB pressures this season and is two sacks shy of breaking the franchise record of 55 set by Tony Brackens in 2003. Allen has 53 1/2 over seven seasons. Williams has been one of the best left tackles in the NFL for years.

Jaguars: WR Dyami Brown (shoulder) missed practice Wednesday and is questionable. Backup RB Bhayshul Tuten (shoulder) was wearing a non-contact jersey in practice for the second straight week but has no injury designation for the game.

49ers: QB Brock Purdy will return this week after missing two games with a toe injury. ... Bosa went down with a season-ending right knee injury last week. ... WR Jauan Jennings missed last week's game with an ankle injury and is questionable this week.

The Niners have won the past five meetings in the series after the Jaguars won the first two. ... San Francisco has outscored Jacksonville by 22.2 points per game in those wins. ... The Jaguars' previous win in the series came at home in 2005 and they have never beaten the 49ers on the road, losing in 2009 and 2017.

The Jaguars have lost 11 of their past 12 road games, including one against Chicago in London last year. They are 4-15 all time on the West Coast, with three of those wins coming against the Raiders in nearby Oakland. … Jacksonville would be 3-0 and one of the biggest surprises in the NFL had rookie standout Travis Hunter not been flagged — a highly questionable call, at best — for pass interference on a fourth down play at Cincinnati in Week 2. … Jacksonville’s defense has been the most efficient aspect of the team. The unit is allowing 17 points a game, the franchise’s best three-game showing to start a season since 2018. … The Jaguars lead the NFL with 13 dropped passes, including six by Brian Thomas Jr. … Jaguars RBs Travis Etienne and Bhayshul Tuten are two of six players with touchdowns rushing and receiving this season. … DT Arik Armstead is facing the Niners for the first time since spending the first nine years of his NFL career in San Francisco. … CB Jourdan Lewis leads the NFL with six pass defenses. ... The 49ers are seeking their fifth 4-0 start in the Super Bowl era. They made it to the Super Bowl three of the four previous times, winning it all in the 1984 season. ... San Francisco has won all three games by five points or fewer after going 24-34 in one-score games in their first eight seasons under coach Kyle Shanahan. ... The 49ers have won back-to-back games despite being outrushed in both. They had won just two games in the three previous regular seasons combined when getting outgained on the ground. ... San Francisco WR Ricky Pearsall’s eight catches on throws at least 15 yards downfield lead the NFL. ... San Francisco RB Christian McCaffrey's 77 touches from scrimmage are the most for any player through three games since Derrick Henry had 92 in 2021 and most ever for a Niners player. ... McCaffrey's 21 first downs rushing and receiving lead the NFL. ... San Francisco has gone 10 straight games without recording an INT, one shy of the NFL record last done by Giants in 2024. ... The Niners have no TD runs through three games for the first time since 1978.

With San Francisco's pass-catching group banged up, Ricky Pearsall has emerged as the No. 1 option. He ranks third in the NFL with 281 yards receiving and his eight catches on throws at least 15 yards downfield lead the NFL.

AP NFL: https://apnews.com/hub/nfl

San Francisco 49ers' Ricky Pearsall (1) catches a pass from teammate Mac Jones to set up a touchdown by Kyle Juszczyk (44) in the second half of an NFL football game against the Arizona Cardinals in Santa Clara, Calif., Sunday, Sept. 21, 2025. (Carlos Avila Gonzalez/San Francisco Chronicle via AP)

Houston Texans cornerback Derek Stingley Jr. (24) breaks up a pass intended for Jacksonville Jaguars wide receiver Brian Thomas Jr. (7) during the first half of an NFL football game Sunday, Sept. 21, 2025, in Jacksonville, Fla. (AP Photo/John Raoux)

San Francisco 49ers' Mykel Williams (98) pressures Arizona Cardinals' Kyler Murray, left, into an intentional grounding penalty while in the end zone in the second half of an NFL football game in Santa Clara, Calif., Sunday, Sept. 21, 2025. (Carlos Avila Gonzalez/San Francisco Chronicle via AP)

KYIV, Ukraine (AP) — Russia unleashed a major missile and drone barrage on Ukraine overnight into Saturday, after U.S. and Ukrainian officials said they’ll meet on Saturday for a third day of talks aimed at ending the nearly 4-year-old war,

Following talks that made progress on a security framework for postwar Ukraine, the two sides also offered the sober assessment that any “real progress toward any agreement” ultimately will depend “on Russia’s readiness to show serious commitment to long-term peace.”

The statement from U.S. special envoy Steve Witkoff, Trump’s son-in-law Jared Kushner as well as Ukrainian negotiators Rustem Umerov and Andriy Hnatov came after they met for a second day in Florida on Friday. They offered only broad brushstrokes about the progress they say has been made as Trump pushes Kyiv and Moscow to agree to a U.S.-mediated proposal to end the war.

Russia used 653 drones and 51 missiles in the wide-reaching overnight attack on Ukraine, which triggered air raid alerts across the country and came as Ukraine marked Armed Forces Day, the country’s air force said Saturday morning.

Ukrainian forces shot down and neutralized 585 drones and 30 missiles, the air force said, adding that 29 locations were struck.

At least eight people were wounded in the attacks, Ukrainian Minister of Internal Affairs Ihor Klymenko said.

Among these, at least three people were wounded in the Kyiv region, according to local officials. Drone sightings were reported as far west as Ukraine’s Lviv region.

Russia carried out a “massive missile-drone attack” on power stations and other energy infrastructure in several Ukrainian regions, Ukraine’s national energy operator, Ukrenergo, wrote on Telegram.

Ukraine’s Zaporizhzhia nuclear power plant temporarily lost all off-site power overnight, the International Atomic Energy Agency said Saturday, citing its Director General Rafael Mariano Grossi.

The plant is in an area that has been under Russian control since early in Moscow’s invasion of Ukraine and is not in service, but it needs reliable power to cool its six shut-down reactors and spent fuel, to avoid any catastrophic nuclear incidents.

Ukrainian President Volodymyr Zelenskyy said that energy facilities were the main targets of the attacks, also noting that a drone strike had “burned down” the train station in the city of Fastiv, located in the Kyiv region.

Russia’s Ministry of Defense said its air defenses had shot down 116 Ukrainian drones over Russian territory overnight into Saturday.

Russian Telegram news channel Astra said Ukraine struck Russia’s Ryazan Oil Refinery, sharing footage appearing to show a fire breaking out and plumes of smoke rising above the refinery. The Associated Press could not independently verify the video.

The General Staff of the Ukrainian Armed Forces later said Ukrainian forces had struck the refinery. Ryazan regional Gov. Pavel Malkov said a residential building had been damaged in a drone attack and that drone debris had fallen on the grounds of an “industrial facility,” but did not mention the refinery.

Months of Ukrainian long-range drone strikes on Russian refineries have aimed to deprive Moscow of the oil export revenue it needs to pursue the war. Meanwhile, Kyiv and its western allies say Russia is trying to cripple the Ukrainian power grid and deny civilians access to heat, light and running water for a fourth consecutive winter, in what Ukrainian officials call “weaponizing” the cold.

The latest round of attacks came as U.S. President Donald Trump’s advisers and Ukrainian officials said they’ll meet for a third day of talks on Saturday, after making progress on finding agreement on a security framework for postwar Ukraine.

Following Friday’s talks, the two sides also offered the sober assessment that any “real progress toward any agreement” ultimately will depend “on Russia’s readiness to show serious commitment to long-term peace.”

The statement from U.S. special envoy Steve Witkoff, Trump’s son-in-law Jared Kushner as well as Ukrainian negotiators Rustem Umerov and Andriy Hnatov came after they met for a second day in Florida on Friday. They offered only broad brushstrokes about the progress they say has been made as Trump pushes Kyiv and Moscow to agree to a U.S.-mediated proposal to end nearly four years of war.

Follow AP’s coverage of the war in Ukraine at https://apnews.com/hub/russia-ukraine

Workers and military inspect Ukrainian Fire Point's Flamingo missiles during handover to the military in an undisclosed location in Ukraine Thursday, Dec. 4, 2025. (AP Photo/Efrem Lukatsky)