WASHINGTON (AP) — The most widely used COVID-19 vaccines may offer a surprise benefit for some cancer patients – revving up their immune systems to help fight tumors.
People with advanced lung or skin cancer who were taking certain immunotherapy drugs lived substantially longer if they also got a Pfizer or Moderna shot within 100 days of starting treatment, according to preliminary research being reported Wednesday in the journal Nature.
And it had nothing to do with virus infections.
Instead, the molecule that powers those specific vaccines, mRNA, appears to help the immune system respond better to the cutting-edge cancer treatment, concluded researchers from MD Anderson Cancer Center in Houston and the University of Florida.
The vaccine “acts like a siren to activate immune cells throughout the body,” said lead researcher Dr. Adam Grippin of MD Anderson. “We’re sensitizing immune-resistant tumors to immune therapy.”
Health Secretary Robert F. Kennedy Jr. has raised skepticism about mRNA vaccines, cutting $500 million in funding for some uses of the technology.
But this research team found its results so promising that it is preparing a more rigorous study to see if mRNA coronavirus vaccines should be paired with cancer drugs called checkpoint inhibitors — an interim step while it designs new mRNA vaccines for use in cancer.
A healthy immune system often kills cancer cells before they become a threat. But some tumors evolve to hide from immune attack. Checkpoint inhibitors remove that cloak. It's a powerful treatment – when it works. Some people’s immune cells still don’t recognize the tumor.
Messenger RNA, or mRNA, is naturally found in every cell and it contains genetic instructions for our bodies to make proteins. While best known as the Nobel Prize-winning technology behind COVID-19 vaccines, scientists have long been trying to create personalized mRNA “treatment vaccines” that train immune cells to spot unique features of a patient's tumor.
The new research offers “a very good clue” that maybe an off-the-shelf approach could work, said Dr. Jeff Coller, an mRNA specialist at Johns Hopkins University who wasn’t involved with the work. “What it shows is that mRNA medicines are continuing to surprise us in how beneficial they can be to human health.”
Grippin and his Florida colleagues had been developing personalized mRNA cancer vaccines when they realized that even one created without a specific target appeared to spur similar immune activity against cancer.
Grippin wondered if the already widely available mRNA coronavirus shots might also have some effect, too.
So the team analyzed records of nearly 1,000 advanced cancer patients undergoing checkpoint inhibitor treatment at MD Anderson – comparing those who happened to get a Pfizer or Moderna shot with those who didn’t.
Vaccinated lung cancer patients were nearly twice as likely to be alive three years after beginning cancer treatment as the unvaccinated patients. Among melanoma patients, median survival was significantly longer for vaccinated patients – but exactly how much isn’t clear, as some of that group were still alive when the data was analyzed.
Non-mRNA vaccines such as flu shots didn’t make a difference, he said.
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The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education and the Robert Wood Johnson Foundation. The AP is solely responsible for all content.
FILE - A healthcare worker prepares a shot of the Pfizer COVID-19 vaccine in La Paz, Bolivia, Jan. 7, 2025. (AP Photo/Juan Karita, File)
Launch preparations have begun for the Artemis II mission, NASA’s planned lunar fly-around by four astronauts that will be the first moon trip in 53 years.
Tensions were high as hydrogen fuel started flowing into the rocket hours ahead of the planned launch. Dangerous hydrogen leaks erupted during a countdown test earlier this year, forcing a lengthy flight delay.
The launch team needs to load more than 700,000 gallons of fuel (2.6 million liters) into the 32-story Space Launch System rocket on the pad before the Artemis II crew can board.
The 32-story Space Launch System rocket is poised to blast off Wednesday evening with a two-hour launch window beginning at 6:24 p.m. EDT at Kennedy Space Center in Florida.
Artemis astronauts Reid Wiseman, Victor Glover, Christina Koch and Jeremy Hansen will be on board. They’ll hurtle several thousand miles beyond the moon, hang a U-turn and then come straight back. No circling around the moon, no stopping for a moonwalk — just a quick out-and-back lasting less than 10 days. NASA promises more boot prints in the gray lunar dust, but not before a couple practice missions.
Unlike the Apollo missions that sent astronauts to the moonfrom 1968 through 1972, Artemis’ debut crew includes a woman, a person of color and a Canadian citizen.
Artemis II is the opening shot of NASA’s grand plans for a permanent moon base. The space program is aiming for a moon landing near the lunar south pole in 2028.
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The wind is picking up at Cape Canaveral, more clouds are appearing and rain is expected in about two hours. But there is no lightning threat, NASA says, and there’s still an 80% chance the weather will be good enough to launch.
L-minus tracks the overall time to liftoff, counting down the days, hours and minutes away before the planned blastoff. It doesn’t include built-in holds, or pauses — that’s T-minus time.
The T-minus countdown in the final 10 minutes is where nerves tense up and hearts start pounding. Automated software kicks off a series of highly choreographed milestones. During this period, the clock can be stopped if a problem is spotted and restarted if it’s fixed in time.
T-0 is the moment of liftoff — zero — when the boosters ignite and the rocket begins its journey.
NASA has a narrow time frame each month to fly to the moon.
The Earth and moon must be aligned just so to achieve the proper trajectory for the mission. In any given month, there’s only about a week when Artemis II astronauts can lift off.
The Orion capsule needs to get a check of its life-support and other systems in near-Earth orbit. If that goes well, Orion will fire its main engine to hurtle toward the moon, taking advantage of the moon and Earth’s gravity to get there and back in a slingshot maneuver that requires little if any fuel.
Orion also needs sunlight for power and can’t be in darkness for more than 90 minutes at a time. Plus NASA wants to minimize heating during reentry at flight’s end.
The latest launch window runs through April 6. The next opportunity opens on April 30.
The hydrogen tank of the rocket’s core stage is 100% filled. NASA said no significant leaks have been observed so far in fueling. It was hydrogen leaks that prevented the rocket from flying in February.
The alarm clocks just went off in Kennedy Space Center’s crew quarters.
That means it’s rise and shine for the three Americans and one Canadian who are about to become the first lunar visitors in more than 53 years.
They have a long day ahead of them, whether they launch or not.
After breakfast, they’ll start suiting up. NASA’s launch window opens at 6:24 p.m. and lasts a full two hours.
Launch director Charlie Blackwell-Thompson is wearing green as are many of the controllers alongside her in the firing room.
Green represents “go” for NASA, a color symbolizing good luck.
The team is monitoring the fueling of the 322-foot moon rocket, set to blast off Wednesday evening.
A plush toy named Rise will ride with the Artemis II astronauts around the moon, carrying the names of more than 5.6 million people.
Rise is what’s known as a zero gravity indicator, which gives the astronauts a visual cue of when they reach space.
The design was inspired by the iconic “Earthrise” photo during Apollo 8, showing the planet as a shadowed blue marble from space in 1968.
Rise was selected from more than 2,600 contest submissions. It was designed by Lucas Ye of California.
Commander Reid Wiseman and his crew tucked a small memory card into Rise before the toy was loaded into the Orion capsule. The card bears the names of all those who signed up with NASA to vicariously tag along on the nearly 10-day journey.
“Zipping that little pocket on the bottom of Rise was kind of the moment that put it all together for me,” Wiseman said. “We are going for all and by all. It’s time to fly.”
NASA is fueling the new rocket that will send four astronauts to the moon.
Launch teams have begun pumping more than 700,000 gallons (2.6 million liters) of liquid hydrogen and liquid oxygen into the Space Launch System rocket at Kennedy Space Center in Florida.
It’s the latest milestone in the two-day countdown that kicked off on Monday when launch controllers reported to duty.
It will take at least four hours to fully load the rocket before astronauts climb aboard for humanity’s first flight to the moon since Apollo 17 in 1972.
The two-hour launch window opens at 6:24 p.m. EDT.
▶ Read more about Apollo vs. Artemis
The Americans who blazed the trail to the moon more than half a century ago were white men chosen for their military test pilot experience.
The Artemis II crew includes a woman, a person of color and a Canadian, products of a more diversified astronaut corps.
▶ Read more about Christina Koch, Victor Glover, Jeremy Hansen and Reid Wiseman
NASA's Artermis II moon rocket sits on Launch Pad 39-B at the Kennedy Space Center hours ahead of planned liftoff Wednesday, April 1, 2026, in Cape Canaveral, Fla. (AP Photo/Chris O'Meara)
NASA's Artermis II moon rocket sits on Launch Pad 39-B at the Kennedy Space Center hours ahead of a planned launch attempt Wednesday, April 1, 2026, in Cape Canaveral, Fla. (AP Photo/Chris O'Meara)
Photographers set up remote cameras near NASA's Artermis II moon rocket on Launch Pad 39-B just before sunrise at the Kennedy Space Center Tuesday, March 31, 2026, in Cape Canaveral, Fla. (AP Photo/Chris O'Meara)
