DENVER--(BUSINESS WIRE)--Oct 27, 2025--
Cleerly, a leader in AI-based cardiovascular imaging, presented new, late-breaking science from the international CONFIRM2 Registry at the Transcatheter Cardiovascular Therapeutics (TCT) 2025 Conference at the Moscone Center in San Francisco, CA.
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The study, "AI-Guided Quantitative Plaque Evaluation from CT to Identify Patients with Future Myocardial Infarction or Death," analyzed 6,550 symptomatic patients (48% male, mean age 59) over 4.4 years who underwent coronary computed tomography angiography (CCTA) with AI-based quantitative coronary CT analysis (AI-QCT) across international sites.
The findings indicated:
Notably, many events occurred in patients who did not have obstructive coronary artery disease (CAD), reinforcing the critical need to look beyond stenosis severity alone when assessing cardiovascular risk.
"These results challenge our traditional approach to cardiac risk assessment," said Alexander Van Rosendael, MD, PhD, the study's first author. "By identifying high-risk plaque features, particularly large non-calcified lesions, we can now detect vulnerable patients who would have been missed by conventional stenosis-focused evaluations."
The CONFIRM2 findings continue to highlight the value of AI-QCT technology in identifying patients with hidden disease, informing earlier intervention strategies, and helping enable more targeted therapeutic approaches. These results suggest that high-risk plaque features may represent important therapeutic targets for prevention and intervention, potentially transforming how clinicians approach cardiovascular risk stratification and management.
About Cleerly
Cleerly is the company on a mission to eliminate heart attacks by creating a new standard of care for heart disease. Through its FDA-cleared solutions driven by artificial intelligence, Cleerly supports comprehensive phenotyping of coronary artery disease, as determined from advanced noninvasive CT imaging. Cleerly’s approach is grounded in science, based on millions of images from over 40,000 patients. Led by a world-class clinical and technical team, Cleerly enhances health literacy for each and every stakeholder in the coronary care pathway. For more information, please visit: cleerlyhealth.com.
CONFIRM2 Registry Demonstrates Prognostic Value of AI-Based Plaque Characterization Beyond Stenosis Severity
MINNEAPOLIS (AP) — A judge made no immediate decision Wednesday on Minnesota's request to suspend the Trump administration's immigration crackdown in the state, where federal agents have yanked people from cars and confronted angry bystanders demanding they pack up and leave.
Plumes of tear gas, the deployment of chemical irritants and the screech of protest whistles have become common on the streets of Minneapolis, especially since an immigration agent fatally shot Renee Good in the head on Jan. 7 as she drove away.
“What we need most of all right now is a pause. The temperature needs to be lowered," state Assistant Attorney General Brian Carter said during the first hearing in a lawsuit filed by Minnesota and the cities of Minneapolis and St. Paul.
U.S. District Judge Katherine Menendez promised to keep the case “on the front burner” and gave the U.S. Justice Department until Monday to file a response to the request for a restraining order. Local leaders say the government is violating free speech and other constitutional rights with the surge of law enforcement.
Menendez said the state and cities will have a few more days to respond.
“It is simply recognition that these are grave and important matters,” the judge said of the timetable, noting there are few legal precedents to apply to some of the key points in the case.
Justice Department attorney Andrew Warden suggested the slower approach set by Menendez was appropriate.
The judge is also handling a separate lawsuit challenging the tactics used by Immigration and Customs Enforcement and other federal officers when encountering protesters and observers. A decision could be released this week.
The Department of Homeland Security says it has made more than 2,000 arrests in the state since early December and is vowing to not back down. The Pentagon is preparing to send military lawyers to Minneapolis to assist, CNN reported.
“What we see right now is discrimination taking place only on the basis of race: Are you Latino or are you Somali? And then it is indiscriminate thereafter,” Minneapolis Mayor Jacob Frey told Fox News. “In other words, they are pulling people off the streets. They have pulled U.S. citizens off the streets and you don’t need to take my word for it at this point. This has been very well documented."
The president of Oglala Sioux Tribe in South Dakota said four tribal members were detained while at a homeless camp in Minnesota last week. Three remained in custody late Tuesday.
“Enrolled tribal members are citizens of the United States by statute and citizens of the Oglala Sioux Nation by treaty,” said tribe President Frank Star Comes Out, who demanded their release.
Associated Press reporters Ed White in Detroit and Graham Lee Brewer in Oklahoma City, Oklahoma, contributed.
Federal officers stand guard after detaining people outside of Bishop Henry Whipple Federal Building, Tuesday, Jan. 13, 2026, in Minneapolis. (AP Photo/Adam Gray)
People visits a makeshift memorial for Renee Good, who was fatally shot by an ICE officer last week, Tuesday, Jan. 13, 2026, in Minneapolis. (AP Photo/John Locher)
A person is detained by federal agents near the scene where Renee Good was fatally shot by an ICE officer last week, Tuesday, Jan. 13, 2026, in Minneapolis. (AP Photo/Adam Gray)
