DENVER--(BUSINESS WIRE)--Oct 27, 2025--
Cleerly, a leader in AI-based cardiovascular imaging, presented new, late-breaking science from the international CONFIRM2 Registry at the Transcatheter Cardiovascular Therapeutics (TCT) 2025 Conference at the Moscone Center in San Francisco, CA.
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The study, "AI-Guided Quantitative Plaque Evaluation from CT to Identify Patients with Future Myocardial Infarction or Death," analyzed 6,550 symptomatic patients (48% male, mean age 59) over 4.4 years who underwent coronary computed tomography angiography (CCTA) with AI-based quantitative coronary CT analysis (AI-QCT) across international sites.
The findings indicated:
Notably, many events occurred in patients who did not have obstructive coronary artery disease (CAD), reinforcing the critical need to look beyond stenosis severity alone when assessing cardiovascular risk.
"These results challenge our traditional approach to cardiac risk assessment," said Alexander Van Rosendael, MD, PhD, the study's first author. "By identifying high-risk plaque features, particularly large non-calcified lesions, we can now detect vulnerable patients who would have been missed by conventional stenosis-focused evaluations."
The CONFIRM2 findings continue to highlight the value of AI-QCT technology in identifying patients with hidden disease, informing earlier intervention strategies, and helping enable more targeted therapeutic approaches. These results suggest that high-risk plaque features may represent important therapeutic targets for prevention and intervention, potentially transforming how clinicians approach cardiovascular risk stratification and management.
About Cleerly
Cleerly is the company on a mission to eliminate heart attacks by creating a new standard of care for heart disease. Through its FDA-cleared solutions driven by artificial intelligence, Cleerly supports comprehensive phenotyping of coronary artery disease, as determined from advanced noninvasive CT imaging. Cleerly’s approach is grounded in science, based on millions of images from over 40,000 patients. Led by a world-class clinical and technical team, Cleerly enhances health literacy for each and every stakeholder in the coronary care pathway. For more information, please visit: cleerlyhealth.com.
CONFIRM2 Registry Demonstrates Prognostic Value of AI-Based Plaque Characterization Beyond Stenosis Severity
NEW YORK (AP) — An Air Canada regional jet struck a firetruck on the runway after landing at New York’s LaGuardia Airport late Sunday night, crushing the nose of the plane, according to authorities and photos of the wreckage.
Two people were killed, according to a person familiar with the investigation into the crash. The person spoke to The Associated Press on condition of anonymity because they were not authorized to discuss an active investigation.
Two Port Authority employees who were traveling in the fire truck also were injured, the person said.
There were 72 passengers and four crew members aboard the aircraft, a Jazz Aviation flight operating on behalf of Air Canada, according to a statement from the airline. The flight originated at Montréal-Pierre Elliott Trudeau International Airport, the major airport serving Montreal.
The Port Authority of New York and New Jersey said in a statement that the jet had struck a rescue and firefighting vehicle that was responding to a separate incident at about 11:45 p.m. The airport was closed as of 3 a.m. to facilitate the investigation, officials said.
Photos and videos from the scene showed severe damage to the front of the aircraft, with cables and debris hanging from a mangled cockpit. Nearby, a damaged emergency vehicle lay on its side.
Stairways used to evacuate passengers from aircraft were pushed up to the emergency exits on the jet, a Bombardier CRJ. The impact left the jet with its crumpled nose tilted upward.
In the moments before the crash, an air traffic controller could be heard on a radio transmission giving clearance to a vehicle to cross part of the tarmac, then trying to stop it.
“Stop, Truck 1. Stop,” the transmission says. The controller can then be heard frantically diverting incoming aircraft from landing.
Jazz Aviation issued a statement confirming the accident and noting the passenger and crew list was preliminary and subject to confirmation.
The National Transportation Safety Board said it was investigating the incident.
A Port Authority aircraft rescue and firefighting vehicle lays on its side off of runway 4 after colliding with an Air Canada jet after it landed at LaGuardia Airport, Monday, March 23, 2026, in New York. (AP Photo/Ryan Murphy)
An Air Canada Jet sits on the runway at LaGuardia Airport, Monday, March 23, 2026, after colliding with a Port Authority aircraft rescue and firefighting vehicle after landing in New York. (AP Photo/Ryan Murphy)
Firetrucks lineup outside LaGuardia Airport, Monday, March 23, 2026, in New York, after an Air Canada Jet collided with a Port Authority vehicle on a runway. (AP Photo/Ryan Murphy)
An Air Canada Jet sits on the runway at LaGuardia Airport, Monday, March 23, 2026, after colliding with a Port Authority aircraft rescue and firefighting vehicle in New York. (AP Photo/Ryan Murphy)
An Air Canada Jet sits on the runway at LaGuardia Airport, Monday, March 23, 2026, after colliding with a Port Authority vehicle in New York. (AP Photo/Ryan Murphy)
An Air Canada Jet sits on the runway at LaGuardia Airport, Monday, March 23, 2026, after colliding with a Port Authority aircraft rescue and firefighting vehicle in New York. (AP Photo/Ryan Murphy)
An Air Canada Jet sits on the runway at LaGuardia Airport, Monday, March 23, 2026, after colliding with a Port Authority vehicle in New York. (AP Photo/Ryan Murphy)
An Air Canada Jet sits on the runway at LaGuardia Airport, Monday, March 23, 2026, after colliding with a Port Authority vehicle in New York. (AP Photo/Ryan Murphy)
Firetrucks lineup outside LaGuardia Airport, Monday, March 23, 2026, in New York, after an Air Canada Jet collided with a Port Authority vehicle on a runway. (AP Photo/Ryan Murphy)
FILE - A control tower is seen at Laguardia International Airport on Saturday, Nov. 8, 2025, in New York. (AP Photo/Olga Fedorova, File)
An Air Canada Jet sits on the runway at LaGuardia Airport, Monday, March 23, 2026, after colliding with a Port Authority vehicle in New York. (AP Photo/Ryan Murphy)
