Texans stifle Patrick Mahomes and Chiefs in 20-10 victory to keep pace in AFC South race

KANSAS CITY, Mo. (AP) — The Houston Texans never made their trip to Arrowhead Stadium on Sunday night into anything more than their next game.

Didn't matter that the Kansas City Chiefs had been the AFC's bully for the better part of a decade. Or the Chiefs had knocked Houston out of the playoffs last year. Or that the Texans needed to win to keep pace with Jacksonville in the AFC South.

“It was our next game,” Texans coach DeMeco Ryans said. “We needed to come out and execute. Play good football. And we did.”

Did enough, anyway.

C.J Stroud threw for 203 yards and a touchdown, the Texans leaned on the NFL's top-ranked defense to shut down Patrick Mahomes and the Chiefs, and Houston walked out with a 20-10 victory that gave a big boost to their postseason hopes.

Nico Collins contributed four catches for 121 yards, and Dare Ogunbowale added a go-ahead touchdown run in the fourth quarter, as the Texans (8-5) won their fifth straight overall and remained a game back of the Jaguars in a tight division race.

“We did what we came to do,” Ryans said. “It was just about accomplishing your mission. It wasn't anything extra on top for winning this game. We just knew we had to get the win no matter what it took.”

Mahomes, operating behind an ailing offensive line, was 14 of 33 for 160 yards with no touchdowns and three interceptions. The last of the picks came late in the fourth quarter, when Kansas City was trailing by a touchdown and trying to get the game to overtime.

“I thought our defense did a great job sticking in coverage, and relentlessly rushing," Stroud said. "An amazing job.”

While the win gave a big boost to Houston's playoff chances, whether it be a division title or wild-card spot, it dealt a crippling blow to the defending AFC champs. Kansas City dropped to 6-7, its worst record through 13 games since a 2-11 start to the 2012 season.

“You're getting late in the season. You're not going to get these opportunities back,” Mahomes said. “That's a good football team, but we had chances and we didn't execute at the right time to win it.”

The Chiefs had won five straight against the Texans, including that divisional playoff matchup last January on their way to another Super Bowl appearance. But they were two different teams entirely when they returned for the rematch Sunday night.

The streaking Texans were trying to keep their momentum going, and perhaps join a rare club of teams that includes Houston's 2018 version that started 0-3 and made the playoffs. And the once-dominant Chiefs were simply trying to stay in the postseason fight amid a dismal season marked by injuries, underwhelming performances and too many mistakes across the board.

The first half turned into a microcosm of all of it.

Stroud, who played so well against Indianapolis last week in his return from a concussion, connected with Collins for a 46-yard gain that set up Ka'imi Fairbairn's field goal and a 53-yard catch that led to a short touchdown toss to Woody Marks.

Meanwhile, the Chiefs sustained two more significant injuries, this time to left tackle Wanya Morris and cornerback Trent McDuffie, leaving them without their best defensive back and Mahomes working with an offensive line consisting of three backups.

“Listen, they battled,” Chiefs coach Andy Reid said afterward. “Some of the guys in there hadn't practiced much.”

Still, the Chiefs wound up with just 98 first-half yards, and they trailed 10-0 at the break. It was only the fourth time with Mahomes at quarterback and the second time in the regular season that the Chiefs had been shut out in the first half.

The Chiefs' defense held its own, though, forcing Stroud into eight consecutive incompletions to start the second half. It allowed Mahomes and the offense to pick away at their deficit, first on Kareem Hunt's TD run and then on Harrison Butker's tying field goal.

Ultimately, the game hinged on two fourth-down decisions in the fourth quarter.

With the score still 10-10, the Texans had fourth-and-1 at their own 35 and punted. The Chiefs were then held to fourth-and-1 at their own 31, chose to go for it, and watched Mahomes throw incomplete with just over 10 minutes remaining.

Six plays later, Ogunbowale plowed into the end zone from 5 yards out to give Houston the lead again.

The Chiefs failed on fourth down again moments later, when Rashee Rice dropped a wide-open pass that would have produced a first down. And after Kansas City got the ball back one last time, Mahomes was picked off to end any hope of a comeback.

“We've still got an opportunity. Even though it's a slim opportunity, we have an opportunity,” Chiefs defensive tackle Chris Jones said. “For us, the door is still open. It might be a 10 percent chance. It might be a 5 percent chance. But as long as we have an opportunity and a chance, we can control that, and let the cards fall where they fall.”

Texans: RB Nick Chubb (ribs) left in the first half and did not return.

Chiefs: RG Trey Smith (ankle) and RT Jawaan Taylor (triceps) were inactive. Morris (knee) and CB McDuffie (knee) got hurt in the first half, leaving Kansas City with a patchwork offensive line and without its best defensive back.

Houston plays the Cardinals next Sunday.

Kansas City plays the Chargers the same day.

AP NFL: https://apnews.com/hub/nfl

Houston Texans quarterback C.J. Stroud (7) throws a touchdown pass during the first half of an NFL football game against the Kansas City Chiefs Sunday, Dec. 7, 2025, in Kansas City, Mo. (AP Photo/Charlie Riedel)

Kansas City Chiefs quarterback Patrick Mahomes (15) scrambles as Houston Texans defensive end Denico Autry, left, defends during the first half of an NFL football game Sunday, Dec. 7, 2025, in Kansas City, Mo. (AP Photo/Charlie Riedel)

Houston Texans cornerback Ameer Speed (37) reacts to Kansas City Chiefs kicker Harrison Butker (7) missing a field goal attempt during the first half of an NFL football game Sunday, Dec. 7, 2025, in Kansas City, Mo. (AP Photo/Charlie Riedel)

Houston Texans cornerback Kamari Lassiter (4) is congratulated by teammate Jalen Pitre, left, after intercepting a pass during the second half of an NFL football game against the Kansas City Chiefs Sunday, Dec. 7, 2025, in Kansas City, Mo. (AP Photo/Ed Zurga)

Houston Texans running back Dare Ogunbowale, right, scores past Kansas City Chiefs defensive back Chamarri Conner during the second half of an NFL football game Wednesday, Jan. 7, 2026, in Kansas City, Mo. (AP Photo/Ed Zurga)

維也納--(BUSINESS WIRE)--十二月 8, 2025--

(美國商業資訊)-- AOP Health持續推進其在骨髓增生性腫瘤(一類特殊且罕見的血液腫瘤)領域的臨床研發計畫。這家專注於罕見疾病治療的公司，於2025年在美國佛羅里達州奧蘭多舉行的第67 屆美國血液學會(American Society of Hematology, ASH)年會上，發布了兩項科學研究成果，將為治療策略帶來新的見解。

本新聞稿包含多媒體資訊。完整新聞稿請見此： https://www.businesswire.com/news/home/20251207103807/zh-HK/

ROP-ET與BESREMI PASS

其中一項臨床研究ROP-ET，探討Ropeginterferon alfa-2b在 原發性血小板增多症 (ET)患者中的使用情況。ET是一種由於體內產生的血小板過多而引發的疾病。此試驗為一項前瞻性、多中心、單組第III期臨床研究，評估Ropeginterferon alfa-2b在無法接受現有細胞減量治療 1 的ET患者中的安全性與療效。

另一項研究為BESREMI-PASS研究，旨在觀察該藥物在 原發性紅血球增多症 (PV)患者日常臨床治療中的效果。PV是一種罕見的血液幹細胞癌症，起源於骨髓造血幹細胞，會導致紅血球、白血球及血小板長期異常增多。

致力於滿足尚未被滿足的醫療需求

上述兩項研究，皆為Ropeginterferon α-2b在協助慢性血癌患者治療方面提供了新的見解。

AOP Health執行長Martin Steinhart總結道： 「AOP Health創立的初衷，正是為了回應罕見疾病領域中尚未被滿足的患者需求。我們對研發的持續投入，正體現了這項承諾，並帶來了新的研究成果。我們很榮幸能在ASH年會上，與全球科學界分享這些發現。」

關於Ropeginterferon alfa-2b

Ropeginterferon alfa-2b為全球首個獲准用於治療真性紅血球增多症(MPN)的干擾素藥物。依據歐盟核准內容，該藥物可作為單一療法，用於治療未出現脾腫大症狀的成人真性紅血球增多症患者。

Ropeginterferon alfa-2b屬於長效單聚乙二醇化脯氨酸干擾素(ATC：L03AB15)。初始治療階段為每兩週給藥一次，待血液學指標穩定後，可延長至每四週給藥一次。藥品採用預充式注射筆設計，供患者進行皮下注射使用。

關於AOP Health

AOP Orphan Pharmaceuticals GmbH (「AOP Health」)為一家跨國企業集團，根植於奧地利，集團總部亦設於此。自1996年成立以來，AOP Health Group持續致力於開發創新治療方案，以回應尚未被滿足的醫療需求，重點聚焦於罕見疾病與重症醫學領域。作為整合式治療方案的國際先驅，AOP Health Group透過子公司、代表處及強大的合作夥伴網路，在全球多地開展業務。秉持「需求、科學、信任」的核心理念，AOP Health Group強調對科研的長期承諾，並重視與醫療專業人士及病友組織的合作，確保關鍵利害關係人的需求能貫穿於公司各項行動之中。(aop-health.com)

1 Kiladjian JJ、Marin FF、Al-Ali HK等。ROP-ET：一項評估Ropeginterferon α-2b在治療選擇有限之原發性血小板增多症患者中有效性與安全性的前瞻性第III期臨床試驗。《血液學年鑑》，2024年3月4日：1–2。

需求、科學、信任。(Needs. Science. Trust.)
AOP Orphan Pharmaceuticals GmbH
AOP Health Group成員

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CONTACT: 深入咨詢

DI Isolde Fally

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SOURCE: AOP Health

Copyright Business Wire 2025.

PUB: 12/08/2025 12:14 AM/DISC: 12/08/2025 12:15 AM

http://www.businesswire.com/news/home/20251207103807/zh

AOP Health執行長Martin Steinhart博士；圖片來源：AOP Health/Studio Koekart