HanchorBio Announces Oral Presentation of HCB101 at the ESMO Immuno-Oncology Congress 2025

International debut underscores emerging role for macrophage checkpoint therapy in gastric cancer, triple-negative breast cancer, and other hard-to-treat solid tumors

TAIPEI, SHANGHAI, AND SAN FRANCISCO, Dec. 11, 2025 /PRNewswire/ -- HanchorBio Inc. (TPEx: 7827), a global clinical-stage biotechnology company advancing next-generation immunotherapies for oncology and autoimmune diseases, today announced that new clinical data from its flagship macrophage-checkpoint program, HCB101, has been selected for a mini oral presentation at the ESMO Immuno-Oncology Congress 2025 in London, United Kingdom. Only 26 abstracts were chosen for mini-oral presentation this year, marking a major milestone for HanchorBio as it delivers its first-ever oral presentation of clinical data at an international oncology congress, following its prior preclinical oral presentation of HCB101 at CSCO 2022.

The ESMO Immuno-Oncology Congress is Europe's premier meeting dedicated exclusively to immuno-oncology science, distinct from the broader ESMO Annual Congress. While the annual ESMO meeting spans all oncology disciplines, ESMO-IO focuses on immune mechanisms, translational innovation, and next-generation therapeutic strategies across innate and adaptive immunity.

Presentation Details:

Abstract ID: 242MO
Title: HCB101, a Differentiated SIRPα Fusion Protein, Demonstrates Favorable Safety and Early Antitumor Activity Across Solid Tumors and Lymphoma
First Author: Dr. Fangling Ning, Affiliated Hospital of Binzhou Medical University
Date / Time: 11 December 2025 / 11:45 – 12:45 GMT
Location: Whittle Room, Queen Elizabeth II Centre, London
Presenter: Alvin Luk, PhD, MBA, CCRA - President & CMO (Group) and CEO (U.S.A.), TIME100 Health 2025 Honoree

"For nearly a decade, CD47 therapies were held back not by flawed biology but by flawed molecules, which struggled to balance safety and efficacy at the same time, especially in immunologically cold tumors," said Scott Liu, PhD, Founder, Chairman, and CEO of HanchorBio. "HCB101 was engineered from the ground up to solve that problem. Using AI-guided structural modeling, we identified three core mutations that reshape SIRPα's interaction with CD47, allowing us to combine the strengths of first- and second-generation approaches into a single, differentiated molecule. Being selected as one of only 26 mini-oral presentations at ESMO Immuno-Oncology reinforces the field's recognition of this effort and redefines the CD47 therapies. With its clean safety profile, strong target engagement, and early activity in cold tumors, HCB101 is emerging as a true macrophage-checkpoint backbone – much like the transformative PD-1/PD-L1 therapies that were based on T-cell checkpoint inhibition."

Key Findings Highlighted in the Mini-Oral

Monotherapy (HCB101-101; NCT05892718)

• Clean, cytopenia-sparing safety across 12 cohorts up to 36 mg/kg QW
• No bleeding events or immune-related toxicities, with the majority of treatment-related adverse events being Grade 1-2
• Linear PK (T_1/2 ~3 days) with receptor occupancy (RO) >99% at ≥8 mg/kg
• Durable antitumor activity, including confirmed PRs in:
  • HNSCC -Head and neck squamous cell carcinoma (~42% tumor regression, ≥32 weeks)
  • MZL - Marginal zone lymphoma (~89% tumor regression, ≥16 weeks)

• Stable disease ≥4-9 months across colorectal cancer (CRC), ovarian cancer, non-small cell lung cancer (NSCLC), and sarcoma
• Combination Therapy (HCB101-201; NCT06771622)
• Well-tolerated across gastric cancer (GC), triple-negative breast cancer (TNBC), CRC, and HNSCC
• No new safety signals across all evaluated combinations
• Cytopenias fully attributable to chemotherapy, not HCB101
• 2L GC:
  • 58.3% ORR (7/12) for all cohorts evaluated, 77.8% ORR (7/9) for mid-dose cohorts, and 100% DCR
  • Tumor shrinkage up to -78.2%

• 1L HER2+ GC: 33% ORR (1/3)
• 1L TNBC: 50% ORR (3/6) and 100% DCR

• 58.3% ORR (7/12) for all cohorts evaluated, 77.8% ORR (7/9) for mid-dose cohorts, and 100% DCR
• Tumor shrinkage up to -78.2%

Alvin Luk, PhD, MBA, CCRA, President & Chief Medical Officer (Group) and Chief Executive Officer (U.S.A.) of HanchorBio, added, "The early efficacy signals from HCB101 are unusually compelling for this stage of development. In second-line GC, where standard therapy achieves an ORR of about 27%, HCB101 combinations exceed 78% ORR, achieve 100% disease control, and result in tumor reduction approaching -78%. These results are not incremental; they meaningfully exceed expectations and reflect robust macrophage checkpoint engagement. With clean safety and sustained receptor occupancy, the data give us confidence to anchor development in second-line disease and expand into first-line and perioperative settings where depth and durability of response matter most."

About HCB101: A Next-Generation SIRPα Fc-Fusion Protein

HCB101 is a 3.5^th-generation engineered SIRPα-Fc fusion protein with an intact IgG4 Fc backbone, developed using HanchorBio's FBDB™ platform to selectively target tumor CD47 while minimizing binding to red blood cells. This design avoids the anemia and thrombocytopenia that limited early anti-CD47 programs, while preserving potent macrophage activation and downstream T-cell engagement. Key differentiators include:

• Cytopenia-sparing safety up to 30-36 mg/kg
• Receptor occupancy (RO) >99% at clinically active exposures
• Strong macrophage and downstream T-cell activation
• Broad antitumor activity across >80 PDX/CDX models and multiple clinical tumor types
• Robust early combination efficacy in tumors that historically respond poorly to immunotherapy

Unlike earlier approaches, HCB101's safety, target selectivity, and RO profile support its use as a macrophage-checkpoint backbone – analogous to how PD-1/PD-L1 inhibitors function as foundational T-cell backbones in oncology. HCB101 is designed for broad combinability across established and emerging treatment modalities, including:

• Chemotherapy
• Antibody-drug conjugates (ADCs)
• Anti-PD-1/anti-PD-L1 checkpoint inhibitors
• Anti-VEGF inhibitors
• Anti-EGFR therapies
• Anti-HER2 regimens

This versatility positions HCB101 as a modular, next-generational immuno-oncology component capable of enhancing the efficacy of multiple therapeutic backbones across solid tumors and hematologic malignancies.

About HanchorBio

Based in Taipei, Shanghai, and the San Francisco Bay Area, HanchorBio (TPEx: 7827) is a global biotechnology company specializing in immuno-oncology. It is led by an experienced team of pharmaceutical industry veterans with a proven track record in biologics discovery and international development, aiming to rewrite the landscape of cancer therapies. Committed to reactivating the immune system to fight diseases, the proprietary Fc-based designer biologics (FBDB™) platform enables the development of unique biologics with diverse multi-targeting modalities, unleashing both innate and adaptive immunity to overcome the current challenges of anti-PD1/L1 therapies. The FBDB™ platform has successfully delivered proof-of-concept data in several in vivo tumor animal models. By advancing breakthroughs in multi-functional, innovative molecular configurations in R&D and improving CMC manufacturing processes, HanchorBio develops transformative medicines to address unmet medical needs. For more information, please visit: https://www.hanchorbio.com/

** The press release content is from PR Newswire. Bastille Post is not involved in its creation. **

HanchorBio Announces Oral Presentation of HCB101 at the ESMO Immuno-Oncology Congress 2025

SINGAPORE, March 10, 2026 /PRNewswire/ -- Banyan Tree, the flagship brand of Banyan Group ("Banyan Tree Holdings Limited" or the "Group" – SGX: B58) is expanding its global spa & wellbeing offerings with the next evolution of its signature Banyan Tree Connections programme. Following its successful launch in 2025, the programme now introduces Connections Retreats, immersive small-group wellbeing journeys designed to deepen personal reflection and shared experiences. The initiative will also expand the signature private programme to eight additional Banyan Tree destinations worldwide, alongside new visiting practitioner residencies and a global partnership with Manduka.

"For more than three decades, Banyan Tree has pioneered a holistic approach to wellbeing, where environments, rituals and traditions come together to nurture presence and personal renewal," said Paul Hawco, Executive Director, Integrated Wellbeing, Banyan Group. "Banyan Tree Connections was created in response to a growing longing for deeper human connection, and as the programme evolves, we are also enriching our spa and wellbeing experiences through thoughtfully curated gatherings, from immersive retreats and seasonal celebrations to expert-led workshops and meaningful collaborations. Guided by our 8 Pillars of Wellbeing philosophy, these programmes unfold across our Sanctuaries for the Senses worldwide, inviting guests to move, reflect, learn, and reconnect."

Introducing Connections Retreats

At the heart of the next phase of the brand's enhanced spa and wellbeing offerings is the launch of Connections Retreats, immersive multi-day wellbeing journeys designed for small groups seeking deeper personal reflection and shared experiences. Each retreat is shaped by the natural rhythms and cultural context of its destination, inviting guests to slow down and reconnect through guided practices such as mindfulness, movement, meditation and local rituals.  

Featured retreats in 2026 include:

• Connections Retreat with Manduka ambassador Nicole Marty (21^st to 25^th May; Mamula Island by Banyan Tree in Montenegro) - A restorative retreat centred on deep connection with oneself, others, and nature. Set overlooking the tranquil waters of Boka Bay, the programme features grounding yoga, mindful movement, and moments of stillness guided by Paris-based Manduka ambassador Nicole Marty, whose teaching blends Hatha and Vinyasa with restorative practices, creating space for rest, renewal, and reflection.

• Connections Retreat with Nadya Hutagalung (29^th Oct to 2^nd Nov 2026; Buahan, A Banyan Tree Escape in Bali) - Set within a lush jungle landscape and inspired by the Balinese philosophy of Tri Hita Karana, this retreat combines meditation, sound healing, mindful movement and reflective dialogue. Led by sustainability advocate Nadya Hutagalung, the experience explores reconnection with self, community and nature.

Global Expansion of Banyan Tree Connections Private Immersions for Two

The introduction of Connections Retreats follows the successful launch of Banyan Tree Connections, which was  introduced in 2025 as a private holistic wellbeing immersion for two. Available at Banyan Tree Anji in China, Banyan Tree Mayakoba in Mexico, Banyan Tree Phuket in Thailand, and Banyan Tree Vabbinfaru in the Maldives, the programme integrates movement, mindfulness and shared rituals to nurture both inner balance and relational harmony between partners, friends or family members.

The private immersion will expand to eight additional Banyan Tree destinations from May 2026, including Banyan Tree AlUla in Saudi Arabia, Banyan Tree Dubai in the United Arab Emirates, Banyan Tree Lang Co in Vietnam, Banyan Tree Nanjing Garden Expo in China, Banyan Tree Samui in Thailand, and in Indonesia, Banyan Tree Bintan and Buahan, A Banyan Tree Escape. It will also be available at Banyan Tree Guangzhou Jiulong Lake in China when the resort opens later this year.

Visiting Practitioner Residencies

Alongside these initiatives, Banyan Tree continues to expand its Visiting Practitioner Programme, welcoming internationally recognised wellbeing experts for limited-time residencies across selected destinations. These intimate sessions range from workshops and day retreats to bespoke private consultations, offering guests opportunities to engage with diverse healing modalities and global wellbeing expertise.

Upcoming programmes include:

• Wellbeing with Vitality by Yuttana Poncharoen (Jimmy) (11^th to 13^th March; Banyan Tree Krabi) - Set amidst Krabi's tranquil natural surroundings, this residency draws on Jimmy's decades of teaching experience in Vinyasa yoga. Rooted in the philosophy of conscious flow, the sessions guide guests through thoughtfully sequenced practices that integrate movement, breath and awareness, cultivating resilience, clarity and a deeper connection with the restorative rhythms of nature.

• Visiting Residency with Manduka ambassador Florence Piers (3rd to 24^th August; Mamula Island by Banyan Tree) - A certified kinesiologist and yoga teacher trained in India, Florence Piers will lead a series of curated sessions designed to cultivate stillness, emotional resilience, and mindful self-awareness. Through Vinyasa, Gentle and Yin Yoga, alongside personalised private sessions, guests are invited to move, breathe and reconnect. Set against the serene rhythms of Mamula Island, each practice encourages presence, balance, and a gentle return to one's natural state of wellbeing.

Extending Banyan Tree's Wellbeing Ecosystem

Complementing these experiences, Banyan Tree has entered a global partnership with Manduka, the world's leading brand of performance yoga mats and accessories. Manduka's performance yoga equipment will be integrated across selected destinations, while Manduka-affiliated practitioners will lead selected retreats and Visiting Practitioner residencies, creating wellbeing journeys rooted in purpose, presence and meaningful connection.

Guests can also immerse themselves in restorative travel through Banyan Tree's Wellbeing Sanctuaries, dedicated room categories introduced across the brand's resorts around the world. These signature sanctuaries offer curated sleep rituals, nourishing cuisine and destination-inspired daily practices, alongside thoughtfully designed in-room amenities that encourage mindfulness and gentle movement.

For more information on upcoming retreats, visiting practitioner residencies and other spa & wellbeing experiences across Banyan Tree destinations, please visit www.banyantree.com/wellbeing-events

For high-resolution images, please download here

ABOUT BANYAN GROUP

Banyan Group ("Banyan Tree Holdings Limited" or the "Group" - SGX: B58) is an independent, global hospitality company with purpose. The Group prides itself on its pioneering spirit, design-led experiences and commitment to responsible stewardship. Its extensive portfolio spans 100 hotels and resorts, more than 140 spas and galleries, and 20 plus branded residences in over 20 countries. Comprising 12 global brands, including the flagship brand Banyan Tree, each distinct yet united under the experiential membership programme withBanyan. The founding ethos of "Embracing the Environment, Empowering People" is embodied through the Banyan Global Foundation and Banyan Academy. Banyan Group is committed to remaining the leading advocate of sustainable travel, with a focus on regenerative tourism and innovative programmes that elevate the guest experience.

 

SINGAPORE, March 10, 2026 /PRNewswire/ -- Banyan Tree, the flagship brand of Banyan Group ("Banyan Tree Holdings Limited" or the "Group" – SGX: B58) is expanding its global spa & wellbeing offerings with the next evolution of its signature Banyan Tree Connections programme. Following its successful launch in 2025, the programme now introduces Connections Retreats, immersive small-group wellbeing journeys designed to deepen personal reflection and shared experiences. The initiative will also expand the signature private programme to eight additional Banyan Tree destinations worldwide, alongside new visiting practitioner residencies and a global partnership with Manduka.

"For more than three decades, Banyan Tree has pioneered a holistic approach to wellbeing, where environments, rituals and traditions come together to nurture presence and personal renewal," said Paul Hawco, Executive Director, Integrated Wellbeing, Banyan Group. "Banyan Tree Connections was created in response to a growing longing for deeper human connection, and as the programme evolves, we are also enriching our spa and wellbeing experiences through thoughtfully curated gatherings, from immersive retreats and seasonal celebrations to expert-led workshops and meaningful collaborations. Guided by our 8 Pillars of Wellbeing philosophy, these programmes unfold across our Sanctuaries for the Senses worldwide, inviting guests to move, reflect, learn, and reconnect."

Introducing Connections Retreats

At the heart of the next phase of the brand's enhanced spa and wellbeing offerings is the launch of Connections Retreats, immersive multi-day wellbeing journeys designed for small groups seeking deeper personal reflection and shared experiences. Each retreat is shaped by the natural rhythms and cultural context of its destination, inviting guests to slow down and reconnect through guided practices such as mindfulness, movement, meditation and local rituals.  

Featured retreats in 2026 include:

• Connections Retreat with Manduka ambassador Nicole Marty (21^st to 25^th May; Mamula Island by Banyan Tree in Montenegro) - A restorative retreat centred on deep connection with oneself, others, and nature. Set overlooking the tranquil waters of Boka Bay, the programme features grounding yoga, mindful movement, and moments of stillness guided by Paris-based Manduka ambassador Nicole Marty, whose teaching blends Hatha and Vinyasa with restorative practices, creating space for rest, renewal, and reflection.

• Connections Retreat with Nadya Hutagalung (29^th Oct to 2^nd Nov 2026; Buahan, A Banyan Tree Escape in Bali) - Set within a lush jungle landscape and inspired by the Balinese philosophy of Tri Hita Karana, this retreat combines meditation, sound healing, mindful movement and reflective dialogue. Led by sustainability advocate Nadya Hutagalung, the experience explores reconnection with self, community and nature.

Global Expansion of Banyan Tree Connections Private Immersions for Two

The introduction of Connections Retreats follows the successful launch of Banyan Tree Connections, which was  introduced in 2025 as a private holistic wellbeing immersion for two. Available at Banyan Tree Anji in China, Banyan Tree Mayakoba in Mexico, Banyan Tree Phuket in Thailand, and Banyan Tree Vabbinfaru in the Maldives, the programme integrates movement, mindfulness and shared rituals to nurture both inner balance and relational harmony between partners, friends or family members.

The private immersion will expand to eight additional Banyan Tree destinations from May 2026, including Banyan Tree AlUla in Saudi Arabia, Banyan Tree Dubai in the United Arab Emirates, Banyan Tree Lang Co in Vietnam, Banyan Tree Nanjing Garden Expo in China, Banyan Tree Samui in Thailand, and in Indonesia, Banyan Tree Bintan and Buahan, A Banyan Tree Escape. It will also be available at Banyan Tree Guangzhou Jiulong Lake in China when the resort opens later this year.

Visiting Practitioner Residencies

Alongside these initiatives, Banyan Tree continues to expand its Visiting Practitioner Programme, welcoming internationally recognised wellbeing experts for limited-time residencies across selected destinations. These intimate sessions range from workshops and day retreats to bespoke private consultations, offering guests opportunities to engage with diverse healing modalities and global wellbeing expertise.

Upcoming programmes include:

• Wellbeing with Vitality by Yuttana Poncharoen (Jimmy) (11^th to 13^th March; Banyan Tree Krabi) - Set amidst Krabi's tranquil natural surroundings, this residency draws on Jimmy's decades of teaching experience in Vinyasa yoga. Rooted in the philosophy of conscious flow, the sessions guide guests through thoughtfully sequenced practices that integrate movement, breath and awareness, cultivating resilience, clarity and a deeper connection with the restorative rhythms of nature.

• Visiting Residency with Manduka ambassador Florence Piers (3rd to 24^th August; Mamula Island by Banyan Tree) - A certified kinesiologist and yoga teacher trained in India, Florence Piers will lead a series of curated sessions designed to cultivate stillness, emotional resilience, and mindful self-awareness. Through Vinyasa, Gentle and Yin Yoga, alongside personalised private sessions, guests are invited to move, breathe and reconnect. Set against the serene rhythms of Mamula Island, each practice encourages presence, balance, and a gentle return to one's natural state of wellbeing.

Extending Banyan Tree's Wellbeing Ecosystem

Complementing these experiences, Banyan Tree has entered a global partnership with Manduka, the world's leading brand of performance yoga mats and accessories. Manduka's performance yoga equipment will be integrated across selected destinations, while Manduka-affiliated practitioners will lead selected retreats and Visiting Practitioner residencies, creating wellbeing journeys rooted in purpose, presence and meaningful connection.

Guests can also immerse themselves in restorative travel through Banyan Tree's Wellbeing Sanctuaries, dedicated room categories introduced across the brand's resorts around the world. These signature sanctuaries offer curated sleep rituals, nourishing cuisine and destination-inspired daily practices, alongside thoughtfully designed in-room amenities that encourage mindfulness and gentle movement.

For more information on upcoming retreats, visiting practitioner residencies and other spa & wellbeing experiences across Banyan Tree destinations, please visit www.banyantree.com/wellbeing-events

For high-resolution images, please download here

ABOUT BANYAN GROUP

Banyan Group ("Banyan Tree Holdings Limited" or the "Group" - SGX: B58) is an independent, global hospitality company with purpose. The Group prides itself on its pioneering spirit, design-led experiences and commitment to responsible stewardship. Its extensive portfolio spans 100 hotels and resorts, more than 140 spas and galleries, and 20 plus branded residences in over 20 countries. Comprising 12 global brands, including the flagship brand Banyan Tree, each distinct yet united under the experiential membership programme withBanyan. The founding ethos of "Embracing the Environment, Empowering People" is embodied through the Banyan Global Foundation and Banyan Academy. Banyan Group is committed to remaining the leading advocate of sustainable travel, with a focus on regenerative tourism and innovative programmes that elevate the guest experience.

 

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Banyan Tree Deepens Wellbeing Experiences with Expansion of its Signature Connections Programme, New Retreats, Visiting Practitioners and Global Partnership with Manduka