NEW YORK (AP) — Drugs that treat Type 2 diabetes, HIV and arthritis are among 15 new medications chosen for a Medicare drug price negotiation program that allows the federal government to haggle directly with drug manufacturers, the Trump administration said Tuesday.
The drugs selected include some of the medications on which Medicare spends the most money. That means the deals negotiated this year have the potential to deliver significant savings to taxpayers when they go into effect in 2028.
“For too long, seniors and taxpayers have paid the price for skyrocketing prescription drug costs,” Centers for Medicare and Medicaid Services Administrator Dr. Mehmet Oz said in a statement Tuesday. “Under President Trump’s leadership, CMS is taking strong action to target the most expensive drugs in Medicare, negotiate fair prices, and make sure the system works for patients — not special interests.”
The federal government had until Feb. 1 to announce its list of 15 drugs. The negotiations take place under a 2022 law that allows Medicare to haggle over the price it pays on the most popular and expensive prescription drugs used by older Americans.
The government already has negotiated prices for 25 prescription drugs covered by Medicare, including the massively popular GLP-1 weight-loss and diabetes drugs Ozempic, Rybelsus and Wegovy. This year’s negotiations mark the third round of the program and would mean a total of 40 drugs with lower prices for Medicare enrollees.
This year also marks the first time drugs payable under Medicare Part B are eligible for inclusion in the program. Medicare Part B drugs are outpatient prescriptions, such as medications infused or injected at a doctor’s office. Retail prescription drugs covered under Medicare Part D are also eligible, as they were in past years.
The newly announced drugs up for negotiation include the popular Type 2 diabetes drug Trulicity and an HIV medication called Biktarvy. The neurotoxin Botox, frequently used to reduce the appearance of wrinkles, will also have its price negotiated, but only for Medicare-covered uses, such as treating migraines or overactive bladders.
Among the other drugs selected are treatments for psoriasis, ulcerative colitis, chronic lung disease, depression and various cancers.
Over the past year, some 1.8 million Medicare Part B or Part D enrollees used the 15 drugs, according to the Trump administration. They accounted for about 6% in total Part B and Part D spending, CMS said.
CMS also stated that one Type 2 diabetes drug, whose price was previously negotiated under the program, Tradjenta, will undergo renegotiation.
AARP CEO Dr. Myechia Minter-Jordan called Tuesday’s announcement a “significant step forward.”
“Older Americans across the political spectrum consistently say that lowering drug prices is a top priority, and we thank the Administration for protecting Medicare’s ability to meet that need,” she said in a statement.
The leading trade association for pharmaceutical companies, meanwhile, criticized the law that put the program into effect, the Inflation Reduction Act, and argued policymakers wanting to lower costs should instead rein in insurers and third-party pharmacy benefit managers.
“The IRA continues to show why government price setting is the wrong approach for Americans,” PhRMA Executive Vice President of Policy and Research Elizabeth Carpenter said in a statement.
CMS in November announced negotiated drug prices for 15 drugs that would go into effect in 2027. Reduced prices for the first 10 drugs negotiated by the Biden administration in 2024 went into effect at the start of this year.
The full list of new medications that will be negotiated this year under the program includes: Anoro Ellipta, Biktarvy, Botox and Botox Cosmetic, Cimzia, Cosentyx, Entyvio, Erleada, Kisqali, Lenvima, Orencia, Rexulti, Trulicity, Verzenio, Xeljanz and Xeljanz XR and Xolair.
President Donald Trump attends an event to promote investment in rural health care in the East Room of the White House, Friday, Jan. 16, 2026, in Washington. Standing with the President are Secretary of Health and Human Services, Robert F. Kennedy, Jr., and Mehmet Oz, Administrator for the Centers for Medicare & Medicaid Services. (AP Photo/Evan Vucci)
MINNEAPOLIS (AP) — President Donald Trump seemed to signal a willingness to ease tensions in Minneapolis after a second deadly shooting by federal immigration agents, but there was little evidence Wednesday of any significant changes following weeks of harsh rhetoric and clashes with protesters.
The strain was evident when Trump made a leadership change by sending his top border adviser to Minnesota to take charge of the immigration crackdown. That was followed by seemingly conciliatory remarks about the Democratic governor and mayor.
Trump said he and Gov. Tim Walz, whom he criticized for weeks, were on “a similar wavelength” following a phone call. After a conversation with Mayor Jacob Frey, the president praised the discussion and declared that “lots of progress is being made.”
But on city streets, there were few signs of a shift. Immigration enforcement operations and confrontations with activists continued Wednesday in Minneapolis and St. Paul.
A group of protesters blew whistles and pointed out federal officers in a vehicle on a north Minneapolis street. When the officers’ vehicle moved, a small convoy of activists followed in their cars for a few blocks until the officers stopped again.
Associated Press journalists were in the neighborhood covering the enforcement actions. When the journalists got out of their car to document the encounter, officers with the federal Bureau of Prisons pushed one of them, threatened them with arrest and told them to get back in their car despite the reporters' identifying themselves as media.
Officers from multiple federal agencies have been involved in the enforcement operations. From their car, the AP journalists saw at least one person being pepper sprayed and one detained, though it was unclear if that person was the target of the operation or a protester. Agents also broke car windows.
Attorney General Pam Bondi, who is visiting Minnesota, said 16 people were arrested Wednesday on charges of assaulting, resisting or impeding law enforcement in the state. She said more arrests were expected.
“NOTHING will stop President Trump and this Department of Justice from enforcing the law," Bondi said in a social media post.
Messages seeking comment were left with Immigration and Customs Enforcement and the Border Patrol.
Many immigrant families are still fearful of leaving their homes, and Latino businesses are still closed, according to Daniel Hernandez, who owns the Minneapolis grocery store Colonial Market. He also runs a popular Facebook page geared toward informing the Hispanic community in the Twin Cities.
While Colonial Market is open, all but one of the dozen immigrant-run businesses that rented space inside to sell clothes, jewelry and toys have closed since late December, and none has plans to reopen, Hernandez said.
“The reality is the community is still very worried and afraid,” Hernandez said.
Hernandez referenced Border Patrol commander Gregory Bovino, who helped lead the administration's crackdown in the Twin Cities and who has reportedly been assigned elsewhere.
Bovino "was removed, but the tactics so far are still the same," Hernandez said. “Nobody now is trusting the government with those changes.”
The federal enforcement extended to the city’s Ecuadorian consulate, where a federal law enforcement officer tried to enter before being blocked by employees.
Meanwhile, Trump said in a social media post that the mayor was “PLAYING WITH FIRE” by not participating in the enforcement efforts.
Elsewhere on Wednesday, Donnie McMillan placed a cardboard sign reading “In remembrance of my angel” at the makeshift memorial where Alex Pretti was shot.
The Vietnam veteran, 71, kneeled to pay his respects and saluted to honor the nurse whom he said he remembered seeing during his frequent visits to the Veterans Affairs hospital where Pretti worked.
“I feel like I’ve lost an angel right here,” the disabled veteran said, pointing to the growing sidewalk memorial covered in flowers, candles and signs.
“This is not the way we should operate,” added McMillan, who said he served in Vietnam and then in the military police for more than a decade. “I respect everybody, but I respect my angel more, and now he’s no longer with us.”
Also Wednesday, the Department of Homeland Security said two federal agents involved in Petti's shooting have been on leave since Saturday.
In other developments, a man confronted Democratic Rep. Ilhan Omar during a town hall meeting and squirted her with a strong-smelling substance as she denounced the administration. He was tackled and identified by police as 55-year-old Anthony Kazmierczak, a convicted felon who had made online posts supportive of Trump.
Minnesota court records show Kazmierczak was convicted of auto theft in 1989 and has multiple arrests for driving under the influence, along with a slew of traffic offenses. It was not immediately clear if he had an attorney.
In social media posts, Kazmierczak described himself a former network engineer who lives in Minneapolis and had made comments critical of former President Joe Biden, referring to Democrats as “angry and liars.”
Omar continued speaking for about 25 minutes after the man was ushered out by security, saying she would not be intimidated. After the event, she said she was unharmed.
The administration was also being challenged in court. Federal courts were weighing a decision on a lawsuit seeking to pause the crackdown, as well as an order for the head of ICE to appear personally to address what a judge said were failures to grant due process for certain immigrants.
Associated Press writers Mike Catalini in Trenton, New Jersey, and Michael Biesecker in Washington contributed to this report.
This story has been corrected to show that agency's name is Veterans Affairs, not Veterans Administration.
The Ecuadorian consulate stands in Minneapolis, Jan. 28, 2026. (AP Photo/Jack Brook)
Vietnam war veteran Donnie McMillan places a sign that says "In remembrance of my angel" at a memorial set up at the location where Veterans Affairs nurse Alex Pretti was shot by U.S. federal agents, in Minneapolis, Wednesday, Jan. 28, 2026. (AP Photo/Jack Brook)
A person is attended to after federal officers used a chemical irritant on Wednesday, Jan. 28, 2026, in Minneapolis. (AP Photo/Julia Demaree Nikhinson)
A person walks past a memorial honoring Alex Pretti outside the Minneapolis VA hospital on Wednesday, Jan. 28, 2026, in Minneapolis. (Kerem Yücel/Minnesota Public Radio via AP)
A federal officer approaches observers and journalists on Wednesday, Jan. 28, 2026, in Minneapolis. (AP Photo/Julia Demaree Nikhinson)
ADDS MORE INFORMATION Federal Bureau of Prisons officers threaten AP video journalist Mark Vancleave with arrest on Wednesday, Jan. 28, 2026, in Minneapolis. (AP Photo/Julia Demaree Nikhinson)
Federal agents knock on a door of a residence on Wednesday, Jan. 28, 2026, in Blaine, Minn. (AP Photo/Adam Gray)
