Enjin Launches Essence of the Elements: A Cross-Game Multiverse Journey

Essence of the Elements, a year-long quest built around elemental seasons, to fuel ecosystem-wide player onboarding and cross-game exploration

SINGAPORE, Feb. 3, 2026 /PRNewswire/ -- Enjin, the pioneer in metaverse experiences and non-fungible tokens (NFTs), today unveiled Essence of the Elements, a Multiverse initiative built around true player ownership with in-game items that can be used, progressed, and expanded across multiple games. Rather than a single in-game event, Essence of the Elements builds upon the model where players genuinely own their items, carry them between different worlds, and grow their value through cross-game play.

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Through Enjin's Multiverse Dashboard, players link their gaming wallet to access a shared progression system spanning multiple titles. By completing quests and challenges across different games, players earn Essence and unlock new items that evolve beyond any one game, creating a growing set of Multiverse collectibles. Each season—Fire, Water, Wind, and Earth—adds new opportunities to expand an item's utility and unlock additional Multiverse items through play in diverse game environments.

Essence of the Elements expands the original prize pool of past Multiverse chapters. Each season in this event introduces prizes that evolve as players gain Essence. These NFT rewards are infused with Enjin Coin (ENJ), with 50,000 ENJ allocated per season across rewards. At the end of each season, eligible players enter a draw to receive a new seasonal Multiverse item. Each season also features a prize of an exclusive, element-themed Degen NFT with a staking pool capacity of 1 million.

Rene Stefancic, COO of Enjin commented, "Essence of the Elements shows what's possible when players truly own their items. Using NFTs, Enjin enables items that belong to players, not games, and can move, evolve, and unlock new value across multiple worlds. This is about ownership that persists beyond any single title, where progress in one game creates opportunity in another, and players stay in control of what they earn." 

Essence of the Elements is a free-to-play campaign to all gamers from Web3 newcomers to veteran players. Games in the first season include ENJ Excavators, Etherscape, Into the Multiverse, Lost Relics, and The Six Dragons. Additional games may join in future seasons.

Enjin is dedicated to delivering a cross-game journey that continuously evolves and improves, with a fair-play and sustainable structure that can grow over time.

The Essence of the Elements Multiverse Chapter is now live on multiverse.nft.io.

Rene Stefancic, COO at Enjin, available for interview

About Enjin
Enjin is the leading ecosystem for non-fungible tokens (NFTs), offering a comprehensive suite of products for creating, trading, distributing, and integrating NFTs into virtual worlds. As a scalable, accessible platform, Enjin's technology has seen wide application in blockchain games, apps, enterprise programs, and innovative marketing campaigns. The Enjin ecosystem is fueled by Enjin Coin (ENJ), a utility token used to back the value of blockchain assets. To date, over one billion Enjin-powered assets have been created. For more information, visit enjin.io.

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Enjin
Glhaiza Pacheco
E: contact@enjin.io

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Enjin Launches Essence of the Elements: A Cross-Game Multiverse Journey

HANGZHOU, China, April 3, 2026 /PRNewswire/ -- A team led by principal investigators Bobo Dang and Ting Zhou at Westlake University/Westlake Laboratory reported in Science a high-throughput platform for engineering fast-acting covalent protein therapeutics. Their work, titled "A high-throughput selection system for fast-acting covalent protein drugs," opens new avenues for next-generation biologics.

Covalent small-molecule drugs have shown great success in cancer therapy by forming irreversible bonds with their targets. This has inspired efforts to extend covalent strategies to protein therapeutics, especially engineered miniproteins. However, their development is limited by a kinetic mismatch: Miniproteins are rapidly cleared in vivo, whereas covalent bond formation is typically slow. In addition, high-throughput platforms for systematically optimizing covalent protein reactivity have been lacking.

To address this challenge, the researchers proposed that precise spatial positioning of chemical warheads within protein scaffolds could enable molecular preorganization, thereby accelerating covalent bond formation without increasing intrinsic reactivity (Fig. 1).

Based on this concept, the team developed a high-throughput platform that combines yeast surface display with chemoselective protein modification to screen diverse crosslinkers and millions of protein variants. By optimizing warhead placement and the local chemical environment, the platform enables rapid and irreversible target engagement.

Using this platform, the researchers developed a covalent antagonist targeting PD-L1, termed IB101. Structural analysis revealed that IB101 forms a defined binding pocket that precisely positions the warhead in a reactive conformation, greatly accelerating covalent bond formation. Functionally, IB101 effectively blocks the PD-1/PD-L1 immune checkpoint pathway and demonstrates strong antitumor activity in mouse models. Notably, despite its short in vivo half-life, IB101 achieves durable target engagement and tumor suppression, outperforming conventional antibody-based therapies under comparable conditions.

The platform was further applied to cytokine engineering, leading to the development of a covalent IL-18 variant, IB201. This engineered cytokine rapidly forms a covalent interaction with its receptor, enhancing signaling strength and duration. In vivo studies showed that IB201 induces potent antitumor immune responses without detectable systemic toxicity. These results highlight the potential of covalent engineering to improve the efficacy and safety of cytokine-based therapies.

Beyond immunotherapy targets, the platform was also applied to develop a covalent inhibitor targeting the receptor-binding domain (RBD) of SARS-CoV-2. This molecule achieves durable viral neutralization, demonstrating the versatility of the approach across different therapeutic modalities.

This study establishes a general strategy for engineering fast-acting covalent protein therapeutics. By enabling covalent bond formation on timescales compatible with rapid in vivo clearance, the platform overcomes a fundamental limitation in the field.

These findings provide a new framework for designing biologics with both rapid kinetics and sustained target engagement, with broad implications for cancer immunotherapy, antiviral therapy, and beyond.

Media Contact: 

Chi Zhang
media@westlake.edu.cn 
+86-15659837873

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Fast-Acting Covalent Protein Drugs From a New High-Throughput Platform