LONDON--(BUSINESS WIRE)--Feb 11, 2026--
Cynozure, a leading data and AI consultancy, today announced the launch of The Next Horizon: Data, AI and Impact – Cynozure’s 2026 State of the Industry Report.
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Based on insights from 60 senior data and AI leaders across sectors including retail, financial services, consumer goods, technology and non-profit, the report explores how organisations are broadening their focus from building data and AI capability to delivering measurable business outcomes.
Key findings include:
“AI has propelled data into the boardroom,” said Jason Foster, Founder and CEO at Cynozure. “The challenge now is not whether organisations can use data and AI, but whether it is making a meaningful difference to the P&L. Many teams have invested heavily in platforms, teams and experimentation, but still struggle to evidence impact. The organisations that pull ahead in 2026 will be those that treat data and AI as a portfolio of products, tied to outcomes and measured with strong investment and commercial discipline.”
The report also finds that data products are becoming a key mechanism for turning AI capability into sustained performance. Over 70% of leaders expect data products to drive the most value in operational excellence and autonomy, followed by customer experience and growth, and financial performance.
“Data products, and increasingly decision products, are how leaders are turning strategy into reality,” said Tim Connold, Chief Client Officer at Cynozure. “By framing data and AI as products that support specific decisions, organisations can focus investment on what matters most and track Return on Data Investment (RODI)™ in a way that resonates with boards and investors.”
The 2026 State of Data and AI Leadership survey was in field from 28 October to 21 November 2025. Respondents were 60 senior data professionals, including Chief Data Officers, Chief Data and Analytics Officers, Chief Data and AI Officers, VPs and Directors of Data, Heads of Data and other senior executives, with nearly half of respondents reporting revenue over £1B.
The Next Horizon: Data, AI and Impact – Cynozure’s 2026 State of the Industry Report is available to download now.
Download the full report: https://www.cynozure.com/state-of-the-industry-report-2026/
About Cynozure
Cynozure is a consultancy that helps leaders ensure data and AI investment translates into clear P&L impact. The company works with organisations to shape data and AI strategies tied to business goals, design and deliver data and decision products that drive real outcomes, build architectures and governance that enable fast and safe platforms, improve data culture and literacy, and define and track Return on Data Investment (RODI)™.
Cynozure also runs the CDO Hub, an exclusive members’ community where data leaders collaborate, share, learn and grow, and produces the Hub & Spoken podcast, one of the most listened to podcasts in the industry. The company has been recognised as one of The Sunday Times’ fastest-growing private companies and as DataIQ’s Best Place to Work in Data in both 2023 and 2024. Cynozure is a certified B Corporation.
For more information, visit www.cynozure.com.
Based on insights from 60 senior data and AI leaders across sectors, The Next Horizon: Data, AI and Impact — Cynozure’s 2026 State of the Industry Report — explores how organisations are moving from building capability to delivering measurable outcomes.
AMSTERDAM--(BUSINESS WIRE)--May 22, 2026--
Avanzanite Bioscience B.V., a rapidly growing commercial-stage European specialty pharmaceutical company focused on rare diseases, today reported that its partner, Agios Pharmaceuticals, Inc. (Nasdaq: AGIO), a commercial-stage biopharmaceutical company headquartered in Cambridge, Massachusetts focused on delivering innovative medicines for patients with rare diseases, announced that the European Commission has granted marketing authorisation for PYRUKYND® (mitapivat), an oral pyruvate kinase (PK) activator, in adults for the treatment of anaemia associated with transfusion-dependent and non-transfusion-dependent alpha- or beta-thalassaemia, with an orphan medicinal product designation.
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“Thalassaemia is a complex, chronic and multisystem disease characterised by anaemia, ineffective erythropoiesis and haemolysis, which together place a significant burden on patients, including a substantial impact on quality of life and persistent fatigue,” commented Raffaella Origa M.D., PhD., Professor of Paediatrics at University of Cagliari, Italy and President of the Italian Society of Thalassaemia and Haemoglobinopathies (SITE). “The approval of PYRUKYND in the EU represents an important step forward, introducing a new oral treatment option regardless of genotype or transfusion burden, with the potential to address key aspects of the disease, including reducing transfusion burden and improving patient outcomes.”
The EC’s decision follows the positive opinion issued by the European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP) and is based on results from the global, randomised, double-blind, placebo-controlled ENERGIZE and ENERGIZE-T Phase 3 trials. The approval of PYRUKYND for adults with thalassaemia marks its second indication in the EU, following its 2022 approval for adults with PK deficiency.
“The treatment of thalassaemia continues to place a profound burden on patients and healthcare systems,” said Antonis Kattamis M.D., Professor at the National & Kapodistrian University of Athens, Greece, and an investigator in the PYRUKYND thalassaemia Phase 3 clinical program. “An oral therapy such as PYRUKYND has the potential to transform the care of both transfusion-dependent and non-transfusion-dependent patients, and we welcome being able to provide this option in our clinical practice.”
In June 2025, Avanzanite entered into an exclusive agreement with Agios to commercialise and distribute PYRUKYND across the European Economic Area, the United Kingdom, and Switzerland. Avanzanite will continue to work closely with Agios, local health authorities and patient communities to secure access for PYRUKYND across the EU.
“Today’s approval of Agios’ first-in-class PK activator in the EU is great news for adults living with thalassaemia and we are proud and privileged to partner with Agios to distribute and commercialise this medicine in the region,” said Adam Plich, CEO and Co-Founder of Avanzanite Bioscience. “Our role now is to collaborate with local authorities, drive a successful launch, and enable broad access to PYRUKYND in this indication, helping to ensure no thalassaemia patient is left behind, across the EU.”
This milestone represents the fourth rare disease launch that Avanzanite has led, further demonstrating the strength of its pan-European commercial platform. With a ‘Champions League’ team of more than 100 rare disease professionals conducting operations spanning 32 European countries, the company is well-positioned to partner with biotech innovators to deliver transformative therapies to patients across Europe.
About Thalassaemia
Thalassaemia is a rare, inherited blood disease that affects the production of haemoglobin, the protein in red blood cells responsible for carrying oxygen throughout the body. The disease is categorised into two main types: alpha-thalassaemia and beta-thalassaemia, depending on which globin chain of the haemoglobin is affected. By disrupting haemoglobin production, thalassaemia reduces the number of circulating red blood cells and shortens their lifespan, which leads to anaemia, fatigue, and serious complications.
Some individuals with thalassaemia require regular transfusions (classified as transfusion-dependent thalassaemia), while others only need them intermittently (classified as non-transfusion-dependent thalassaemia). All patients with thalassaemia experience a significant disease burden, including comorbidities, reduced quality of life and shortened life expectancy.
About ENERGIZE and ENERGIZE-T
ENERGIZE ( NCT04770753 ) and ENERGIZE-T ( NCT04770779 ) are global, double-blind, placebo-controlled Phase 3 trials evaluating the efficacy and safety of mitapivat in adults with alpha- or beta-thalassaemia.
The ENERGIZE trial randomised 194 non-transfusion-dependent alpha- or beta-thalassaemia patients 2:1 to receive either mitapivat 100 mg twice daily or placebo. The primary endpoint was haemoglobin response, defined as an increase of ≥1.0 g/dL in average haemoglobin concentration from Week 12 through Week 24 compared with baseline. Key secondary endpoints included changes from baseline in average fatigue scores and in average haemoglobin concentration from Week 12 to Week 24. The trial also assessed safety and tolerability.
The ENERGIZE-T trial randomised 258 transfusion-dependent alpha- or beta-thalassaemia patients 2:1 to receive either mitapivat 100 mg twice daily or placebo. The primary endpoint was transfusion reduction response, defined as a ≥50% reduction in transfused red blood cell (RBC) units with a reduction of ≥2 units of RBCs transfused in any consecutive 12-week period through Week 48 compared with baseline. Several transfusion reduction measures were included as key secondary endpoints, and achievement of transfusion independence was a secondary endpoint. The trial also assessed safety and tolerability.
For each trial, patients who completed the double-blind period had the option to transition into a corresponding open-label extension period, during which all patients receive mitapivat.
About Avanzanite Bioscience
Avanzanite is redefining launches of rare disease medicines across Europe. Founded in 2022 and based in Amsterdam, the Netherlands, the company partners with biotech innovators to unlock the full commercial value of orphan medicines through a fully integrated platform spanning 32 countries. With our deep expertise in market access, we navigate Europe’s complex landscape like master chess players – ensuring no patient is left behind while delivering measurable impact and growth opportunities for alliance partners.
For more information, visit www.avanzanite.com.
Adam Plich, CEO and Co-Founder of Avanzanite Bioscience.
