PALO ALTO, Calif.--(BUSINESS WIRE)--Mar 4, 2026--
Guardant Health, Inc. (Nasdaq: GH), a leading precision oncology company, today announced the launch of Shield Across America, a historic coast-to-coast mobile screening tour bringing Shield, the first and only FDA-approved blood test as a primary colorectal cancer (CRC) screening option and recommended in national guidelines, directly to over 100 communities across the country from Las Vegas to Hartford, Atlanta and more.
This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20260304217437/en/
From national sporting events to rural senior centers and beyond, the tour will educate patients on the importance of CRC screening and provide patients of screening-eligible age the opportunity to screen with Shield via the mobile screening lab. The Shield Across America tour will focus on rural areas that face the biggest barriers to colorectal cancer screening and the highest incidence and mortality rates.
The tour launch coincides with National CRC Awareness Month, underscoring Guardant Health’s commitment to close America’s colorectal cancer screening gap and help more Americans get screened.
CRC remains the second leading cause of cancer-related deaths in the U.S., and recently the leading cancer death for those under 50. Despite being highly treatable when caught early, more than 54 million eligible Americans – 1 in 3 – do not complete their CRC screening because they find current options unpleasant or inconvenient. Shield Across America aims to eliminate the barriers that have kept many Americans from getting screened by expanding access to Shield through mobile screening lab stops nationwide.
“Shield Across America seeks to address a fundamental challenge in colorectal cancer screening in our country: access,” said AmirAli Talasaz, Guardant Health co-CEO. “By bringing screening directly to where Americans live, work and enjoy with a focus on our rural communities who face some of the biggest barriers to screening, we aim to encourage more people to get their lifesaving screening and close our nation’s screening gap.”
Shield is proven to increase screening rates in the real world, with 93% of patients completing the test in the first 100,000 Shield tests ordered – a significant improvement in screening adherence rates over other types of tests. 1 Recently, the National Comprehensive Cancer Network included the Shield blood test in its updated CRC screening guidelines, paving the way for improved patient access and additional major clinical guideline inclusions.
Built on Guardant’s proprietary technology pioneered more than a decade ago, Shield is covered by Medicare, the Veterans Affairs Community Care Network and TRICARE, for active-duty service members, and is commercially available across the U.S.
Shield is available by prescription only and can be completed during a routine doctor’s visit. To find a screening event near you or find more details on the Shield test to discuss with your local provider, visit ShieldAcrossAmerica.com.
About Shield
Shield is a methylation partitioning cell-free DNA (mp-cfDNA) non-invasive, blood-based screening test that detects alterations associated with colorectal cancer in the blood. It is intended as a screening test for individuals at average risk for the disease, age 45 or older, and is not intended for individuals at high risk for colorectal cancer. The Shield test can be considered in a manner similar to guideline-recommended non-invasive CRC screening options and can be completed during any healthcare visit. A positive Shield result raises concern for the presence of colorectal cancer or advanced adenoma and the patient should be referred for colonoscopy evaluation.
About Guardant Health
Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer and treatment selection for patients with advanced cancer. For more information, visit guardanthealth.com and follow the company on LinkedIn, X (Twitter) and Facebook.
Guardant Health Forward-Looking Statements
This press release contains forward-looking statements within the meaning of federal securities laws, including statements regarding the potential utilities, values, benefits and advantages of Guardant Health’s liquid biopsy tests or assays, which involve risks and uncertainties that could cause the actual results to differ materially from the anticipated results and expectations expressed in these forward-looking statements. These statements are based on current expectations, forecasts and assumptions, and actual outcomes and results could differ materially from these statements due to a number of factors. These and additional risks and uncertainties that could affect Guardant Health’s financial and operating results and cause actual results to differ materially from those indicated by the forward-looking statements made in this press release include those discussed under the captions “Risk Factors” and “Management’s Discussion and Analysis of Financial Condition and Results of Operation” and elsewhere in its Annual Report on Form 10-K for the year ended December 31, 2025 and in its other reports filed with or furnished to the Securities and Exchange Commission. The forward-looking statements in this press release are based on information available to Guardant Health as of the date hereof, and Guardant Health disclaims any obligation to update any forward-looking statements provided to reflect any change in its expectations or any change in events, conditions, or circumstances on which any such statement is based, except as required by law. These forward-looking statements should not be relied upon as representing Guardant Health’s views as of any date subsequent to the date of this press release.
1 Inadomi JM, Vijan S, Janz NK, et al. Adherence to colorectal cancer screening: a randomized clinical trial of competing strategies. Arch Intern Med. 2012;172(7):575-582.
Mobile screening bus providing Shield by Guardant Health, the first and only FDA-approved blood test for primary colorectal cancer screening
Explosions sounded in Tehran Wednesday as Iran's war with the U.S. and Israel entered a fifth day following earlier strikes on an Iranian nuclear site and retaliatory strikes by the Islamic Republic across the Gulf region.
The explosions around Tehran came at dawn, according to Iran state television, while Israel’s military said its air defenses had been activated to intercept incoming Iranian missiles and explosions were heard around Jerusalem.
Five days into a war that U.S. President Donald Trump suggested could last a month or longer, nearly 800 people have been killed in Iran, including some Trump said he had considered as possible future leaders of the country.
Explosions also hit Lebanon, where Israel said it is retaliating against Hezbollah militants. Lebanon’s state-run media reported that at least four people were killed in an Israeli strike that hit a residential complex in the city of Baalbeck.
Here is the latest:
An Iraqi official says a senior Iranian official requested that Iraq take measures to prevent Iranian opposition groups based there from breaching the border.
A statement says Ali Bagheri, deputy secretary of Iran’s Supreme National Security Council, made the request in a call with Iraqi National Security Advisor Qassim al-Araji.
The guard says it is prepared for the “complete destruction of the region’s military and economic infrastructure.” The statement came via Iranian state television.
“The continued mischief and deception by the United States in the region will come at the cost of the complete destruction of the region’s military and economic infrastructure,” it says.
It alleges, without offering evidence, that the U.S. military was using “civilian facilities ... as cover.”
The death toll in Iran from the ongoing war with the United States and Israel has reached at least 1,045 people, an Iranian government agency said Wednesday.
The Iran’s Foundation of Martyrs and Veterans Affairs offered the toll, saying it represented the number of bodies so far identified and prepared for burial.
Turkey’s Defense Ministry says NATO defenses have intercepted a ballistic missile launched from Iran before it entered Turkey’s airspace. A ministry statement said the missile was detected after crossing Iraqi and Syrian airspace. NATO air and missile defense units stationed in the eastern Mediterranean intercepted it in time.
Canadian Prime Minister Mark Carney say he sees the war as an extreme example of a rupturing world order in which countries increasingly act without respect for international norms and laws.
“Geo-strategically, hegemons are increasingly acting without constraint or respect for international norms or laws while others bear the consequences. Now the extremes of this disruption are being played out in real time in the Middle East,” Carney said at the Lowy Institute, a Sydney-based international policy think tank.
But whether the U.S. and Israeli airstrikes on Iran broke international law was “a judgment for others to make,” he said.
Grand Ayatollah Ali al-Sistani, a prominent religious leader based in Iraq, condemned the “military aggression” against Iran. He said attacking a country that is a member of the United Nations without U.N. approval is a violation of international law.
The Iran-born al-Sistani, who is one of the world’s most influential Shiite clerics, warned that war would cause widespread chaos and prolonged unrest “that will bring calamities to the peoples of the region and to the interests of others as well.”
Al-Sistani is based in the holy Shiite city of Najaf.
Iranian state television on Wednesday afternoon said the mourning ceremony for Iranian Supreme Leader Ayatollah Ali Khamenei had been postponed and would be held later after intense strikes targeted Tehran.
A Hong Kong expatriate living in Dubai moved hotels twice and encountered high prices for hotels and flights out of the country in her search for safety.
Agnes Chen Pun, a partner at an investment firm, said she was afraid her home in Dubai near the Burj Khalifa skyscraper could be targeted. That prompted her to move Monday into a resort in Fujairah on the eastern coast of the UAE, an around 1.5-hour drive from Dubai.
After spending a peaceful night in Fujairah, however, a fire broke at the port there.
“We see the dark smoke,” she said. “Everyone is like running, rushing in the (hotel) lobby.”
There were limited flights leaving UAE or Oman, and she considered taking a private jet from Oman back to Asia, as some others were doing. The cost, however, was as much as $268,000 for a 13-seat private jet flight.
She finally secured commercial flight tickets at around $2,200 per person for economy class seats for her family for an Emirates flight scheduled to fly out of Dubai to Singapore Wednesday evening.
The Iranian vessel that was sinking off of Sri Lanka, the IRIS Dena, is one of Iran’s newest warships.
The frigate was the centerpiece of a two-ship international tour in 2023 that included port calls in countries including South Africa and Brazil. It was accompanied by the support ship IRIS Makran, a converted oil tanker.
The U.S. Treasury Department included both ships on a sanctions designation in February 2023 along with eight executives of an Iranian drone manufacturer that supplied the weapons to Russia for use against civilian targets in Ukraine.
The Israeli military is ordering people living in dozens of villages in southern Lebanon close to the border with Israel to evacuate and move “immediately” north of the Litani River.
The Israeli army’s Arabic spokesperson warned people on X that if they decide to move south of the river they will be endangering their lives.
The area south of the Litani River is mostly along the border with Israel. The Lebanese government says it has cleared the area of Hezbollah’s military presence there over the past months.
Israel is seeing a decline in launches from Iran as the campaign enters its fifth day, military spokesperson Brig. Gen. Effie Defrin said.
Defrin also said Israel is not surprised by any new weapons Iran may use and had prepared extensively for the confrontation.
He said Israel would continue to “hunt and destroy” Iran’s military capabilities.
Israel has struck more than 250 Hezbollah targets in Lebanon over the past 48 hours, an Israeli army spokesperson said Wednesday.
Spokesperson Effie Defrin said in a recorded statement that the Iran-backed militant group Hezbollah had been launching rockets at Israel overnight.
Defrin said Israel would continue to target Hezbollah until “the threat is removed.”
“I emphasize: We have no issue with the people of Lebanon. The people of Lebanon are paying the price for the Iranian regime,” he said.
A top Sri Lankan official says 32 people have been rescued from a sinking Iranian naval ship off Sri Lanka’s southern coast have been admitted to a hospital.
Dr. Anil Jasinghe, a top health ministry official, says one of them is in critical condition, seven are receiving emergency treatment and others are treated for minor injuries.
Foreign Minister Vijitha Herath told Parliament that Sri Lanka’s navy received information that the ship IRIS Dena with 180 onboard was under distress, and that the island nation sent ships and air force planes on a rescue mission.
There were no immediate details as to how the sailors were wounded and how the ship was damaged.
Kuwait’s military said a new wave of Iranian missiles and drone was targeting the tiny Mideast nation.
Iran’s judiciary chief threatened “those who say or do anything” in support of the U.S.-Israeli airstrike campaign targeting the Islamic Republic.
Gholam Hosseini Mohseni Ejehei’s remarks raised the possibility of those detained facing death-penalty charges, as cooperating with an enemy can carry execution if convicted.
Speaking on state television, he said: “Those who say or do anything in line with the will of America and the Zionist regime are on the enemy’s side and must be dealt with on revolutionary, Islamic principles and in accordance with the time of war.”
The British government says a chartered flight will take off from Oman late Wednesday to bring back some of the thousands of U.K. nationals in the Gulf.
It says the most vulnerable will be prioritized for the first of what is expected to be a series of flights.
The Foreign Office says more than 130,000 British nationals in the Middle East have registered their presence with the government since the U.S.-Israel-Iran conflict broke out, though not all are trying to leave. Many of those are in the United Arab Emirates, and the government has advised against trying to travel overland to Oman.
Commercial airlines are also starting to resume some flights, with Etihad, Emirates and Virgin Atlantic all due to operate flights from the UAE to London on Wednesday.
The Israeli military said one of its F-35 stealth fighter jets shot down a piloted Iranian Air Force YAK-130 fighter over Tehran on Wednesday. Israel described it as the first air-to-air combat kill of a piloted aircraft by the fighter jet.
Iran’s top diplomat is again criticizing U.S. President Donald Trump as America and Israel continue their airstrike campaign targeting his country in the war.
Abbas Araghchi said that “Trump betrayed diplomacy and Americans who elected him.”
“When complex nuclear negotiations are treated like a real estate transaction, and when big lies cloud realities, unrealistic expectations can never be met,” Araghchi wrote on X. “The outcome? Bombing the negotiation table out of spite.”
The war began Saturday after Israel launched an airstrike killing Iranian Supreme Leader Ayatollah Ali Khamenei. The U.S. and Iran had held three rounds of nuclear negotiations prior to the start of the war, but no deal had been reached.
As the fighter jets roared overhead, those still in Tehran looked anxiously to the skies.
One man who ran a clothing shop said he didn’t know what, if anything, he could do.
“It’s very difficult to decide what to do. If I leave the city, how am I supposed to earn money and survive?” said the man, who spoke on condition of anonymity for fear of reprisals.
“I just hope the Arabs do not get involved. If they do, their missiles won’t be as precise as these.”
By Jon Gambrell
Airstrikes also were reported in the Iranian cities of Urmiah and Kermanshah.
The Israeli military said it had begun “broad scale strikes” in Tehran.
Airstrikes struck eastern Tehran later Wednesday morning, witnesses said.
Ukraine’s Foreign Minister Andrii Sybiha said Tuesday he discussed the rapidly evolving situation in the Middle East and its global security implications with Saudi Foreign Minister Prince Faisal bin Farhan.
Sybiha expressed solidarity with Saudi Arabia and condemned what he described as Iran’s aggression, saying it threatens regional stability.
He said the two sides discussed the risks of further escalation and the need for diplomatic solutions, stressing that protecting civilians must remain a priority.
Sybiha noted that Ukraine has firsthand experience with missile and drone warfare, including daily attacks involving Shahed drones.
He said Kyiv is ready to share its expertise with partners facing similar threats.
Earlier, he spoke with his Kuwaiti counterpart, Sheikh Jarrah Jaber Al Sabah.
“For Ukraine, this threat is not abstract. We face daily missile and drone attacks, including Iranian-made Shahed drones used by Russia against our cities and civilians,” Sybiha wrote on X.
Israel’s defense minister on Wednesday threatened whoever Iran picks to be the country’s next supreme leader, saying he will be “a target for elimination.”
Israel Katz made the statement on X.
“Every leader appointed by the Iranian terror regime to continue and lead the plan to destroy Israel, to threaten the United States and the free world and the countries of the region, and to suppress the Iranian people — will be a target for elimination,” he wrote.
Israel targeted a building Tuesday associated with Iran’s Assembly of Experts, which will select the new supreme leader.
Israel killed the 86-year-old Ayatollah Ali Khamenei in a strike Saturday that started the war.
Qatar Airways will remain grounded until at least Friday, the airline said.
Israel’s military said it began new airstrikes in Beirut.
People staying in a hotel in a southeastern suburb of Beirut said the strike that hit the second floor came without warning.
Maggie Shibli, wife of the owner of the Hotel Comfort in the Hazmieh neighborhood, said they were sleeping when the missile hit.
“We live in a country where a missile can fall on your head at any moment,” she said.
Abbas Najdeh, who was displaced from the southern port city of Tyre and was staying at the hotel, said “we were sleeping then suddenly I, my children and my wife were thrown away.”
He added there was no warning.
The U.S. State Department has ordered non-emergency staff and their families working in the consulates in Lahore and Karachi to leave the country due to safety concerns.
Staff at the embassy in the capital Islamabad were not affected by the order.
Pakistan shares a long western border with Iran and has a sizable Shiite Muslim minority.
At least 10 people were killed in Karachi on Sunday after protesters attempted to storm the consulate in the city, Pakistan’s largest.
Starting Wednesday, there will be three nights of public mourning with the casket containing the body of the late 86-year-old Supreme Leader Ayatollah Ali Khamenei in Iran’s capital, Tehran, Iranian state television reported.
The ceremony will take place at the Grand Mosalla of Tehran.
Iranian state television said the latest salvo in the war saw Iran’s paramilitary Revolutionary Guard launch 40 ballistic missiles at targets associated with the U.S. military in the Mideast.
It said it targeted Irbil in Iraq, two military bases in Kuwait, and two U.S. warships.
Strikes hit Lebanon overnight, including in several towns and on a hotel in a suburb right next to the capital.
Beirut woke up to the sounds of drones whizzing overhead.
The Israeli military warned residents in a southern suburb to flee ahead of a morning airstrike, as more displaced people fleeing the conflict pour into the capital seeking shelter.
Overnight Israeli strikes on towns near Beirut have killed at least six people, Lebanon’s Health Ministry said early Wednesday.
Israel struck the towns of Aramoun and Saadiyat just south of Beirut’s international airport, killing six and wounding eight others.
It also struck a hotel in the Beirut suburb of Hazmieh. No casualties were immediately reported there.
The strikes came without warning and the Israeli military did not immediately disclose the targets.
The Israeli military said Wednesday it conducted a series of strikes across Iran’s capital targeting its security forces.
It said it hit buildings associated with the Basij, the all-volunteer force of Iran’s paramilitary Revolutionary Guard that conducted the bloody crackdown on protesters in January that killed thousands and saw tens of thousands detained in the country.
The Israeli military also said it hit buildings associated with Iran’s internal security command, which also has suppressed demonstrations in the past.
Israel and the U.S. have said they want to see the Iranian public overthrow its theocracy.
Strikes against counterprotest forces likely are part of that effort.
An Iranian-backed militant group in Iraq said it fired drones toward Jordan.
The group, Saraya Awliya al-Dam, said that drones were aimed at “a vital target” in the kingdom.
Earlier Wednesday, Jordan’s state-run television reported that sirens sounded across the country.
Iraqi militants on Tuesday threatened to target Jordan over allegations that U.S. aircraft that bombed their facilities took off from a Jordanian air base.
A building associated with the clerical panel that will pick Iran’s next supreme leader came under attack in an airstrike in the holy seminary city of Qom, semiofficial media reported.
The attack Tuesday hit the building in the Resalat neighborhood of Qom.
The semiofficial Fars and Tasnim news agencies, both believed to be close to Iran’s paramilitary Revolutionary Guard, linked the building to Iran’s Assembly of Experts and said there was no meeting ongoing there at the time of the attack.
Fars further went on to say the assembly is meeting remotely, without elaborating.
It added that meetings over naming a new leader are ongoing — suggesting there could be an announcement by Iran in the coming days over who will replace the 86-year-old Supreme Leader Ayatollah Ali Khamenei, who was killed in an Israeli strike at the start of the war Saturday.
There was no report on if anyone was hurt in the strike.
Israel’s public broadcaster KAN said Israel carried out the attack, though there’s been no confirmation from its military.
The Assembly of Experts is an 88-member panel which “must, as soon as possible” pick a new supreme leader under Iranian law.
The panel consists entirely of Shiite clerics who are popularly elected every eight years and whose candidacies are approved by the Guardian Council, Iran’s constitutional watchdog.
The rubble of a police facility struck during the U.S.–Israeli military campaign is seen in Tehran, Iran, Wednesday, March 4, 2026. (AP Photo/Vahid Salemi)
Workers remove the rubble of a police facility struck during the U.S.–Israeli military campaign in Tehran, Iran, Wednesday, March 4, 2026. (AP Photo/Vahid Salemi)
A man carries an Iranian flag to place on the rubble of a police facility struck during the U.S.–Israeli military campaign in Tehran, Iran, Wednesday, March 4, 2026. (AP Photo/Vahid Salemi)
Israeli tanks maneuver near the Israel-Lebanon border, in northern Israel, Wednesday, March 4, 2026. (AP Photo/Ariel Schalit)
An Iranian flag is placed among the ruins of a police station struck Monday during the U.S.–Israeli military campaign in Tehran, Iran, Tuesday, March 3, 2026. (AP Photo/Vahid Salemi)
Firefighters inspect the rubble as smoke rises from a building hit by an Israeli airstrike in Dahiyeh, a southern suburb of Beirut, Lebanon, Tuesday, March 3, 2026. (AP Photo/Hassan Ammar)
Jewish men covered in prayer shawls pray in an underground parking garage as a precaution against possible Iranian missile attacks, in Tel Aviv, Israel, Tuesday, March 3, 2026. (AP Photo/Oded Balilty)
A coffin is carried during the funeral of mostly children killed in what Iranian officials said was an Israeli-U.S. strike Feb. 28 at a girls' elementary school in Minab, Iran, Tuesday, March 3, 2026. (Abbas Zakeri/Mehr News Agency via AP)
A man takes shelter in an underground metro station as a precaution against possible Iranian missile attacks, in Ramat Gan, Israel Monday, March 2, 2026. (AP Photo/Oded Balilty)
Smoke rises from Israeli airstrikes in Dahiyeh, a southern suburb of Beirut, Lebanon, Tuesday, March 3, 2026. (AP Photo/Hussein Malla)
