Where Regenerative Aesthetics Meets Architecture, Fashion, and Cultural Philosophy
SHANGHAI, May 20, 2026 /PRNewswire/ -- On May 6, Aphranel® hosted its "Twin Peaks Lecture" and immersive runway presentation beneath the dome of the Roma Roma exhibition at the Shanghai World Expo Museum, bringing together voices from regenerative aesthetics, fashion, craftsmanship, cultural heritage, and the arts around a central question:
What defines beauty that can truly endure through time?
Held inside the exhibition's "Legends of Gods," surrounded by classical Roman sculptures and beneath a Pantheon-inspired dome, the forum framed a conversation between ancient civilization and contemporary regenerative aesthetics.
"Rome was not built in a day" formed the philosophical foundation of the event. For Aphranel, the phrase speaks to more than a decade of regenerative biomaterial research and development — from pioneering proprietary CaHA microsphere technology to securing China's first Class III medical device approval for an injectable Calcium Hydroxylapatite facial filler, with EU MDR certification now underway.
"A willingness to wait is itself a hallmark of premium craftsmanship," said Lin Guangming, founder of Aphranel.
"The Roman dome represents the integration of engineering, artistry, and belief. Building a regenerative material capable of enduring long-term clinical scrutiny requires the same commitment to precision, patience, and responsibility."
The forum featured a range of guests, including Aphranel founder Lin Guangming, aesthetic medicine experts, museum representatives, curators, fashion leaders, and heritage artisans.
Discussions throughout the evening touched on craftsmanship, regenerative aesthetics, luxury, cultural identity, and the relationship between medicine and art.
Medical experts also addressed the growing shift toward regenerative and anatomy-led aesthetic approaches, highlighting controlled degradation, collagen regeneration, and long-term structural harmony as emerging priorities in aesthetic medicine.
Museum and cultural representatives discussed how ancient Roman architecture and sculpture continue to shape contemporary ideas of beauty, proportion, and permanence, while fashion and art leaders examined the enduring relationship between timeless aesthetics and contemporary visual culture.
As part of the event, Aphranel also presented an immersive runway show inspired by architecture and sculptural form. Models wearing couture looks curated by internationally renowned fashion designer Grace Chen and fashion industry leader Chai Fangjun moved through the colonnade beneath the Roman dome in silhouettes defined by balance, contour, and movement.
The event underscored Aphranel's growing international presence within the regenerative aesthetics sector, as the brand prepares for EU MDR certification.
The forum formed part of Aphranel's ongoing initiative to promote cross-disciplinary dialogue around regenerative aesthetics, long-term aesthetics, and contemporary perspectives on beauty.
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Aphranel Hosts "The Poetics of Time" Cultural Forum at Rome Exhibition in Shanghai
Aphranel Hosts "The Poetics of Time" Cultural Forum at Rome Exhibition in Shanghai
Aphranel Hosts "The Poetics of Time" Cultural Forum at Rome Exhibition in Shanghai
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BEIJING, HANGZHOU, China and CAMBRIDGE, Mass., May 20, 2026 /PRNewswire/ -- METiS TechBio (7666.HK), a global leader in AI-powered drug delivery innovation, today announced that new preclinical data from its heart-targeted LNP program has been selected for a Late-Breaking oral presentation at the 2026 Controlled Release Society (CRS) Annual Meeting. Dr. Andong Liu, Vice President and Head of Technology Platform at METiS TechBio, will deliver a Late-Breaking oral presentation at the 2026 CRS Annual Meeting in Lisbon, Portugal, this July. The presentation is titled "Systemic Heart-Selective Lipid Nanoparticles for High-Efficiency In Vivo Delivery and Cardiomyocyte Gene Editing."
In this study, leveraging its proprietary NanoForge AI nanodelivery platform, METiS TechBio achieved near-complete (~100%) cardiomyocyte transfection and significant gene editing following intravenous administration through AI-driven lipid discovery, formulation optimization, and active targeting ligand engineering. The selection of these findings for a Late-Breaking oral presentation at this year's CRS Annual Meeting represents a significant advance in extrahepatic LNP delivery, establishing a first-in-class precision delivery capability to cardiomyocytes.
The heart has long been considered one of the most challenging organs for extrahepatic LNP delivery. Cardiomyocytes, due to their high density and low endocytic activity, are widely recognized in the industry as one of the most difficult cell types for efficient delivery. Achieving near-complete cardiomyocyte transfection means that, for the first time, genetic medicines may be able to reach cardiomyocytes via systemic administration with substantially improved precision and efficiency while reducing off-target risks. This opens up new therapeutic possibilities for major cardiovascular diseases and clinical needs, including hereditary cardiomyopathies, heart failure, and post-myocardial infarction repair. It also signals that AI-driven organ-targeted delivery technology is advancing from proof-of-concept toward potential clinical value.
"Extrahepatic delivery remains one of the most important challenges in genetic medicine," said Dr. Chris Lai, Chairman and CEO of METiS TechBio. "These findings demonstrate the potential of our AI-driven NanoForge platform to enable precise delivery to cardiomyocytes, which could open new possibilities for in vivo gene editing therapies targeting cardiovascular diseases."
Lipid nanoparticles (LNPs) are a versatile and clinically validated non-viral platform for delivering large genetic payloads. However, achieving organ-specific delivery beyond the liver remains a major unresolved challenge in the field of genetic medicine. In this study, METiS TechBio utilized the high-throughput in vivo screening system and AI lipid design engine under the NanoForge platform to identify LNPs with specific tissue tropism. The research team evaluated candidate LNPs in mTmG mouse models, using Cre-mRNA to induce eGFP expression as a readout for functional intracellular delivery. After identifying lead lipids with heart-specific tropism, the team further optimized the formulation to enhance cellular uptake, and subsequently functionalized the particles with antibody-targeting ligands to generate actively targeted LNPs (tLNPs). To evaluate their therapeutic potential, lead tLNPs were used to deliver the CRISPR-Cas9 system to quantify gene editing efficiency in the myocardium.
The initial lead lipids exhibited a cardiomyocyte delivery efficiency of ~30%, which increased to ~70% following formulation optimization. Upon functionalization with targeting ligands, the cardiomyocyte-targeted tLNP (CM-tLNP) achieved near-complete (~100%) cardiomyocyte transfection. Furthermore, delivery of the CRISPR-Cas9 system resulted in significant genomic editing within the myocardium, confirming the strong therapeutic potential of the platform for cardiac applications.
NanoForge is the world's first AI nanodelivery platform independently developed by METiS TechBio. It features the world's largest ionizable lipid library at the scale of tens of millions, a proprietary lipid de novo generation algorithm and lipid language model, the world's first end-to-end lipid and lipid nanoparticle (LNP) screening platform, and an original AI-powered multiscale simulation platform for small-molecule formulation development. Building upon NanoForge, the Company has developed three major technology solutions: AiTEM, AiLNP, and AiRNA. The AiLNP platform currently provides deep analytical insights through artificial intelligence and molecular dynamics simulations, predicts more than 20 lipid property parameters, and enables the design and optimization of key LNP components and their ratios to build customized, high-performance delivery systems.
Founded in 1978, the Controlled Release Society (CRS) is one of the world's most authoritative non-profit academic organizations in the fields of drug delivery systems and nanomedicine. With members from more than 50 countries and regions, CRS spans interdisciplinary fields including pharmaceutics, materials science, biomedical engineering, nucleic acid therapeutics, and translational medicine. The CRS Annual Meeting attracts thousands of experts from leading international universities, research institutions, and multinational pharmaceutical companies each year, and is regarded as a leading forum and launchpad for global drug delivery and nanomedicine technologies.
About METiS TechBio (7666.HK)
AI nanodelivery, unlocking a healthier future. METiS TechBio is a Hong Kong Stock Exchange-listed company driven by artificial intelligence (AI)-enabled nanomaterial innovation. The Company focuses on leveraging targeted drug delivery and drug discovery technologies to help lives overcome disease and aging, and regain health and vitality.
METiS TechBio was co-founded in 2020 by Dr. Hongmin Chen, a member of the U.S. National Academy of Engineering, together with MIT scientists Dr. Chris Lai and Dr. Wenshou Wang. On May 13, 2026, the Company was successfully listed on the Hong Kong Stock Exchange as the world's first publicly listed AI-powered drug delivery company. The Company has independently developed NanoForge, the world's first AI-powered nanodelivery platform, and possesses the world's largest LNP lipid library at the scale of tens of millions. Building upon NanoForge, it has created three core solutions: AiLNP (AI Nanodelivery System Design Platform), AiRNA (AI mRNA Sequence Design Platform), and AiTEM (AI Small-Molecule Formulation Design Platform).
The Company has achieved the capability to deliver precisely to eight key organs or tissues, including the liver, lungs, muscles, and immune cells. It has made breakthrough progress in addressing the challenges of multi-organ and multi-tissue targeted delivery, creating drug development opportunities in oncology, metabolic diseases, autoimmune diseases, neurodegenerative diseases, and other therapeutic areas, while also enabling organ-level anti-aging interventions.
BEIJING, HANGZHOU, China and CAMBRIDGE, Mass., May 20, 2026 /PRNewswire/ -- METiS TechBio (7666.HK), a global leader in AI-powered drug delivery innovation, today announced that new preclinical data from its heart-targeted LNP program has been selected for a Late-Breaking oral presentation at the 2026 Controlled Release Society (CRS) Annual Meeting. Dr. Andong Liu, Vice President and Head of Technology Platform at METiS TechBio, will deliver a Late-Breaking oral presentation at the 2026 CRS Annual Meeting in Lisbon, Portugal, this July. The presentation is titled "Systemic Heart-Selective Lipid Nanoparticles for High-Efficiency In Vivo Delivery and Cardiomyocyte Gene Editing."
In this study, leveraging its proprietary NanoForge AI nanodelivery platform, METiS TechBio achieved near-complete (~100%) cardiomyocyte transfection and significant gene editing following intravenous administration through AI-driven lipid discovery, formulation optimization, and active targeting ligand engineering. The selection of these findings for a Late-Breaking oral presentation at this year's CRS Annual Meeting represents a significant advance in extrahepatic LNP delivery, establishing a first-in-class precision delivery capability to cardiomyocytes.
The heart has long been considered one of the most challenging organs for extrahepatic LNP delivery. Cardiomyocytes, due to their high density and low endocytic activity, are widely recognized in the industry as one of the most difficult cell types for efficient delivery. Achieving near-complete cardiomyocyte transfection means that, for the first time, genetic medicines may be able to reach cardiomyocytes via systemic administration with substantially improved precision and efficiency while reducing off-target risks. This opens up new therapeutic possibilities for major cardiovascular diseases and clinical needs, including hereditary cardiomyopathies, heart failure, and post-myocardial infarction repair. It also signals that AI-driven organ-targeted delivery technology is advancing from proof-of-concept toward potential clinical value.
"Extrahepatic delivery remains one of the most important challenges in genetic medicine," said Dr. Chris Lai, Chairman and CEO of METiS TechBio. "These findings demonstrate the potential of our AI-driven NanoForge platform to enable precise delivery to cardiomyocytes, which could open new possibilities for in vivo gene editing therapies targeting cardiovascular diseases."
Lipid nanoparticles (LNPs) are a versatile and clinically validated non-viral platform for delivering large genetic payloads. However, achieving organ-specific delivery beyond the liver remains a major unresolved challenge in the field of genetic medicine. In this study, METiS TechBio utilized the high-throughput in vivo screening system and AI lipid design engine under the NanoForge platform to identify LNPs with specific tissue tropism. The research team evaluated candidate LNPs in mTmG mouse models, using Cre-mRNA to induce eGFP expression as a readout for functional intracellular delivery. After identifying lead lipids with heart-specific tropism, the team further optimized the formulation to enhance cellular uptake, and subsequently functionalized the particles with antibody-targeting ligands to generate actively targeted LNPs (tLNPs). To evaluate their therapeutic potential, lead tLNPs were used to deliver the CRISPR-Cas9 system to quantify gene editing efficiency in the myocardium.
The initial lead lipids exhibited a cardiomyocyte delivery efficiency of ~30%, which increased to ~70% following formulation optimization. Upon functionalization with targeting ligands, the cardiomyocyte-targeted tLNP (CM-tLNP) achieved near-complete (~100%) cardiomyocyte transfection. Furthermore, delivery of the CRISPR-Cas9 system resulted in significant genomic editing within the myocardium, confirming the strong therapeutic potential of the platform for cardiac applications.
NanoForge is the world's first AI nanodelivery platform independently developed by METiS TechBio. It features the world's largest ionizable lipid library at the scale of tens of millions, a proprietary lipid de novo generation algorithm and lipid language model, the world's first end-to-end lipid and lipid nanoparticle (LNP) screening platform, and an original AI-powered multiscale simulation platform for small-molecule formulation development. Building upon NanoForge, the Company has developed three major technology solutions: AiTEM, AiLNP, and AiRNA. The AiLNP platform currently provides deep analytical insights through artificial intelligence and molecular dynamics simulations, predicts more than 20 lipid property parameters, and enables the design and optimization of key LNP components and their ratios to build customized, high-performance delivery systems.
Founded in 1978, the Controlled Release Society (CRS) is one of the world's most authoritative non-profit academic organizations in the fields of drug delivery systems and nanomedicine. With members from more than 50 countries and regions, CRS spans interdisciplinary fields including pharmaceutics, materials science, biomedical engineering, nucleic acid therapeutics, and translational medicine. The CRS Annual Meeting attracts thousands of experts from leading international universities, research institutions, and multinational pharmaceutical companies each year, and is regarded as a leading forum and launchpad for global drug delivery and nanomedicine technologies.
About METiS TechBio (7666.HK)
AI nanodelivery, unlocking a healthier future. METiS TechBio is a Hong Kong Stock Exchange-listed company driven by artificial intelligence (AI)-enabled nanomaterial innovation. The Company focuses on leveraging targeted drug delivery and drug discovery technologies to help lives overcome disease and aging, and regain health and vitality.
METiS TechBio was co-founded in 2020 by Dr. Hongmin Chen, a member of the U.S. National Academy of Engineering, together with MIT scientists Dr. Chris Lai and Dr. Wenshou Wang. On May 13, 2026, the Company was successfully listed on the Hong Kong Stock Exchange as the world's first publicly listed AI-powered drug delivery company. The Company has independently developed NanoForge, the world's first AI-powered nanodelivery platform, and possesses the world's largest LNP lipid library at the scale of tens of millions. Building upon NanoForge, it has created three core solutions: AiLNP (AI Nanodelivery System Design Platform), AiRNA (AI mRNA Sequence Design Platform), and AiTEM (AI Small-Molecule Formulation Design Platform).
The Company has achieved the capability to deliver precisely to eight key organs or tissues, including the liver, lungs, muscles, and immune cells. It has made breakthrough progress in addressing the challenges of multi-organ and multi-tissue targeted delivery, creating drug development opportunities in oncology, metabolic diseases, autoimmune diseases, neurodegenerative diseases, and other therapeutic areas, while also enabling organ-level anti-aging interventions.
** This press release is distributed by PR Newswire through automated distribution system, for which the client assumes full responsibility. **
METiS TechBio to Present Late-Breaking Data on Near-Complete Cardiomyocyte Delivery at CRS 2026
