WAUWATOSA, Wis. & NEWARK, Del.--(BUSINESS WIRE)--Jun 10, 2026--
N-Zyme Biomedical, a clinical-stage biotechnology company developing a novel class of therapeutics targeting pepsin in reflux disease, today announced the initiation of its Phase 2 clinical trial to evaluate its lead pepsin inhibitor candidate for the treatment of laryngopharyngeal reflux (LPR).
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The trial represents a key milestone in the development of what is believed to be the first therapeutic approach specifically designed to inhibit pepsin, a primary driver of tissue damage and symptoms in reflux disease.
Unlike traditional acid-suppressing therapies, including proton pump inhibitors (PPIs)that do not address non-acidic components of reflux, N-Zyme’s approach is designed to target pepsin directly—addressing a key mechanism underlying persistent and treatment-resistant symptoms.
LPR, often referred to as “silent reflux,” remains significantly underdiagnosed and undertreated, with many patients continuing to experience chronic symptoms despite standard therapies. By targeting pepsin, N-Zyme is advancing a differentiated approach with the potential to improve outcomes across a large and underserved patient population.
“The initiation of our Phase 2 trial marks an important milestone for N-Zyme and the advancement of a new therapeutic approach in reflux disease,” saidFranco Vigile, Co-Founder and Chief Executive Officer of N-Zyme Biomedical. “For decades, the standard of care has focused primarily on acid suppression, despite growing evidence supporting the role of pepsin in disease pathology—particularly in LPR and other extraesophageal manifestations of reflux. We believe targeting pepsin represents a differentiated approach with the potential to redefine how reflux disease is treated and improve outcomes for millions of patients.”
Strengthened Intellectual Property Portfolio
In parallel with the advancement of its clinical program, N-Zyme recently expanded its intellectual property portfolio with the issuance of patents covering the use of fosamprenavir for the treatment of reflux disease from both the United States Patent and Trademark Office and the Japan Patent Office.
These patents provide strategic protection for the use of fosamprenavir and related compounds in reflux indications and further support the company’s position in developing therapies targeting pepsin.
About the Phase 2 Trial
The Phase 2 clinical trial is designed to evaluate the efficacy and safety of N-Zyme’s pepsin inhibitor candidate, utilizing fosamprenavir, a well-characterized molecule with an established safety profile, in patients diagnosed with laryngopharyngeal reflux. The trial is led by Dr. Nikki Johnston at the Medical College of Wisconsin and is expected to generate data supporting the therapeutic potential of pepsin inhibition.
About N-Zyme Biomedical
N-Zyme Biomedical is a clinical-stage biotechnology company headquartered in Delaware, United States. The company is developing a novel class of therapeutics designed to inhibit pepsin, with the goal of advancing the treatment of reflux disease and addressing a significant unmet medical need.
Attendees gather at N-Zyme Biomedical's Phase 2 Clinical Trial Launch Celebration at the Medical College of Wisconsin.
DUBAI, United Arab Emirates (AP) — The United States launched airstrikes early Wednesday against Iran after blaming Tehran for the crash of an American attack helicopter, and Iran fired back at countries in the region — another escalation that threatened to derail efforts to end the war.
Hours after Bahrain, Kuwait and Jordan came under Iranian fire, U.S. President Donald Trump posted on his his Truth Social platform that Iran was taking “too long to negotiate a deal” and that “now they will have to pay the price.”
It wasn’t clear what exactly that would mean, but the back-and-forth strikes Wednesday again raised the question of how much pressure the deal can take before it cracks. The exchange of fire was the second time this week that such strikes have tested the ceasefire after Iran and Israel targeted each other on Monday.
Trump has repeatedly vacillated between expressing optimism over the talks and warning that he was ready to return to all-out war. Iran, meanwhile, has proved resilient despite having faced weeks of heavy bombing, betting that its ability to effectively close the Strait of Hormuz — a crucial passageway for the world’s oil and natural gas — gives it a strong bargaining chip.
Both countries seem to be looking for a way to end the conflict — if they can manage to sell it as a win at home. But Israeli Prime Minister Benjamin Netanyahu appears intent on pursuing much more difficult goals: the collapse of Iran’s theocratic government, the elimination of its nuclear program, and the destruction of the Iranian-allied Hezbollah militant group in Lebanon. That will make compromise much harder.
Since the U.S. and Israel started the war with attacks on Iran on Feb. 28, the conflict has shaken the global economy, driven up energy prices around the world, and made many basics, including food, more expensive. Brent crude oil, the international standard, was at more than $91 a barrel on Wednesday, up more than 25% since the start of the war.
In the latest strikes, U.S. fighter jets targeted “air defense, ground control stations, and surveillance radar sites,” the military’s Central Command said. Iran acknowledged strikes around Bandar Abbas and Qeshm Island, but gave no details on the damage.
“The operation was a proportional response to recent attacks on U.S. forces and international commercial ships transiting regional waters,” Central Command said.
Iran’s top diplomat vowed that there would be a response, and Tehran later claimed attacks in Kuwait, Bahrain and Jordan.
Jordan said it shot down five incoming missiles, which Iran said targeted the Muwaffaq Salti Air Base. The base has hosted American F-35 fighter jets and other aircraft.
Jordan’s state-run Petra news agency carried a military statement saying there were no injuries and that explosives experts examined the debris from the interceptions.
Bahrain and Kuwait said they intercepted incoming fire, without elaborating.
Iranian Foreign Minister Abbas Araghchi condemned the American attacks as a violation of Iranian sovereignty in calls with his counterparts from Turkey and Saudi Arabia “and emphasized the inherent right of self-defense, including reciprocal action,” according to a post on his office's Telegram channel.
Foreign Ministry spokesperson Esmail Baghaei said in televised comments Wednesday that in light of the new attacks, Iran would review its stance on negotiations to end the war.
The exchanges of fire came a day after a U.S. Army attack helicopter crashed near the Strait of Hormuz after colliding with an Iranian drone, according to a U.S. official, who spoke on condition of anonymity to discuss an ongoing investigation. It wasn’t clear whether the collision was intentional.
A drone boat rescued both of the helicopter’s aviators, and Trump said they were uninjured.
Guards aboard a cargo ship off the coast of Yemen in the Gulf of Aden exchanged fire with gunmen in a small boat and repelled their attack, the British military’s United Kingdom Maritime Trade Operations center said.
No group immediately claimed responsibility. Yemen’s Iran-backed Houthi rebels have said they will resume their attacks against Israel-affiliated ships in the Red Sea. Somali pirates have also become more active in the region.
The UKMTO later reported a fire in the engine room of a tanker in the Gulf of Oman, near the Strait of Hormuz, saying one person had been hurt and two others aboard were missing. It wasn’t immediately clear what caused the fire.
Before he accused Iran of downing the U.S. helicopter, Trump expressed renewed optimism over negotiations with Iran, but didn’t say why there was reason for hope.
While Trump, wary of high gas prices and upcoming congressional elections in November, seems to be looking for a quick win, he is also making demands that will be tough for Iran to swallow.
The U.S. wants to see Iran give up its stockpile of highly enriched uranium. While Iran insists its nuclear program is peaceful, that uranium is a short, technical step from weapons-grade levels.
Iran is refusing to give up the uranium and demanding relief from sanctions. It also wants the release of frozen assets even before a final agreement is in place, something rejected by Trump.
It's not clear how those differences can be bridged — and Trump has repeatedly threatened to walk away from the talks. On his Truth Social platform overnight he seemed to be warning again that he was ready to return to all-out war, posting a clip from the American TV series “The West Wing” with actor Martin Sheen as president bellowing: “We don’t come back with a proportional response, we come back with total disaster!”
Meanwhile, Iran has continued to insist that any deal to end the war must also end fighting between its ally Hezbollah and Israel. Instead, Israel has intensified its military campaign against the militant group.
Israel's military said on Wednesday it launched multiple strikes in southern Lebanon over the past day, targeting Hezbollah infrastructure.
An airstrike on a village east of Tyre killed at least six people, Lebanon's state-run National News Agency reported.
Associated Press writers David Rising in Bangkok; Bassem Mroue in Beirut; Michelle L. Price in New York; and Will Weissert in Washington contributed to this report.
People take shelter as air raid sirens warn of incoming Iranian missiles in Ramat Gan, Israel, Monday, June 8, 2026. (AP Photo/Oded Balilty)
A projectile streaks through the sky over central Israel during an Iranian missile attack, Sunday, June 7, 2026. (AP Photo/Ohad Zwigenberg)
A cleric checks his cell phone on stage in front of a screen displaying portraits of the late Iranian revolutionary founder Ayatollah Khomeini, left, late Supreme Leader Ayatollah Ali Khamenei, center, and Supreme Leader Ayatollah Mojtaba Khamenei, during a pro-government gathering in Tehran, Iran, Sunday, June 7, 2026. (AP Photo/Vahid Salemi)
A woman walks past a mural depicting a U.S. aircraft carrier under missile attack in downtown Tehran, Iran, Monday, June 8, 2026. (AP Photo/Vahid Salemi)
