BEIJING, Oct. 26, 2026 /PRNewswire/ -- On October 24, 2026, in Madrid, Spain, the team of Professors Jie Wang, Zhijie Wang and Jianchun Duan at the Cancer Hospital, Chinese Academy of Medical Sciences, presented Phase 1b/2a results in a Rapid Oral session at ESMO Congress 2026. The study evaluates LK101, a personalized neoantigen dendritic cell (DC) vaccine, plus tislelizumab as first-line maintenance therapy for locally advanced or metastatic non-small cell lung cancer (NSCLC).
Initiated by Professor Jie Wang's team and independently conducted by investigators, the study (NCT05886439) uses LK101 supplied by Likang Life Sciences. Patients had no actionable driver alterations, PD-L1 TPS ≥1%, and disease control following platinum-doublet chemotherapy plus an anti-PD-1 antibody. Non-squamous patients could also receive pemetrexed maintenance. LK101 uses autologous DCs transfected with mRNA encoding up to 30 patient-specific tumor neoantigens.
As of March 31, 2026, 26 patients had enrolled and 25 received LK101. Among 21 efficacy-evaluable patients, four achieved confirmed partial responses. Following vaccine administration, investigator-assessed ORR was 19.0% and DCR was 95.2%. Some patients experienced further tumor shrinkage during maintenance.
From first-line therapy initiation, median follow-up was 9.5 months, median progression-free survival (PFS) was not reached, and PFS rates at 9 and 12 months were 85.4% and 70.4%.
ELISpot analyses showed increased neoantigen-specific T-cell responses following LK101 administration, alongside increased effector CD8+ T-cell proportions. Partial responders had higher post-priming ELISpot responses. These exploratory findings support LK101-induced immune responses and suggest a potential association with clinical activity.
Most LK101-related adverse events were Grade 1–2. Investigators considered the safety profile manageable.
The session discussant described the PFS rates as impressive and commented favorably on the ELISpot findings. Clinical benefit requires further validation.
A multicenter randomized controlled Phase 2 study has been initiated to evaluate the efficacy and safety of LK101 plus tislelizumab as first-line maintenance therapy in advanced NSCLC.
About Likang Life Sciences
Likang Life Sciences is an innovative biotechnology company focused on AI-powered precision cancer immunotherapy. Integrating artificial intelligence, bioinformatics, genomics, and advanced immunotherapy technologies, it develops precision therapies tailored to patient-specific tumor characteristics. Its pipeline includes personalized neoantigen therapeutic vaccines and neoantigen-specific T-cell therapies.
Website: www.likanglife.com
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ESMO 2026 | Professors Jie Wang, Zhijie Wang and Jianchun Duan's Team Reports 95.2% Disease Control With LK101 Combination Maintenance Therapy in Advanced NSCLC
Charting a New Milestone with Outstanding Achievements
HONG KONG, Oct. 26, 2026 /PRNewswire/ -- The Hong Kong International Communications Electronic Chamber (HKICEC) made a landmark debut at the Global Sources Mobile Electronics Show, held from October 18-21, 2026, with the inaugural launch of the HKICEC Global Mobile Exchange Pavilion. Spanning 600 square meters, the pavilion brought together nearly 60 industry leaders from mainland China, Hong Kong, India, Japan, the UAE, the US and the UK. As the largest themed pavilion in the mobile electronics sector and a premier highlight of the exhibition, this event marks a new developmental milestone for HKICEC. The pavilion underscores the chamber's dedication to bridging global markets and serving the communications and electronics industry, injecting vital new momentum into the synergy between Hong Kong's technology sector and international trade.
The grand opening ceremony on October 18 marked the official launch of the first B2B pavilion in Hong Kong and Asia dedicated exclusively to mobile communications equipment. The milestone event was officiated by a distinguished lineup of devices global business, including Dr. the Hon. Starry Lee Wai King, GBS, JP, Member of the Standing Committee of the National People's Congress and President of the Legislative Council; Mr. Zhu Xiaodong, Director of the Kowloon Affairs Department of the Liaison Office of the Central People's Government in the HKSAR; Dr. the Hon. Horace Cheung Kwok Kwan SBS JP, Deputy Secretary for Justice, HKSAR; Mr. Liu Maozhou, Level 1 Bureau Rank Official, the Economic and Financial Department II, Liaison Office of the Central People's Government in the HKSAR; Mr. Ho Lap Ki, Denny, JP, District Officer (Kwun Tong), Home Affairs Department; Mr James Liu, CEO of Global Sources; and Mr. Jacky Tse, Chairman of HKICEC, alongside HKICEC Management team. Together, they witnessed the official launch of the first B2B pavilion in Hong Kong and Asia dedicated to mobile communications equipment. The ceremony drew over a hundred political and business leaders, industry representatives, international exhibitors, and major media outlets, reflecting the event's importance and the industry's green trading development. Following the inauguration, officials toured the pavilion for high-level discussions with global exhibitors, signaling robust institutional backing for the industry and HKICEC's strategic expansion.
During the four-day exhibition, the pavilion experienced a continuous flow of visitors. Communications and electronics suppliers and global buyers from overseas visited specifically for business matchmaking and negotiations, unlocking numerous commercial opportunities. Notably, the pavilion also featured a retrospective exhibit of 16 classic mobile phones, tracing the industry's evolution from early 'brick' devices to Mainland China's first official Apple release, the iPhone 3GS. The historical display proved to be a standout attraction, gathering large crowds throughout the event.
Beyond the exhibition floor, the chamber partnered with Global Sources to co-host an international forum on October 19. Under the theme " From New Devices to New Life: Building a Global Mobile Device Lifecycle Ecosystem", the event gathered experts from ecoATM, PCS Wireless, Cenwood, Our Hong Kong Foundation, and the Global Mobile Association. They engaged in profound discussions on cutting-edge topics including the global economic landscape, inventory management, ESG development, the circular ecology of new and used devices, and AI technology. Attended by over 200 international representatives, the forum successfully catalyzed cross-border collaboration and established a new standard for sustainability discourse in the global mobile industry.
As a capstone to the comprehensive four-day events, HKICEC convened over 500 industry leaders, VIPs, and exhibitors for a high-profile networking banquet designed to accelerate cross-border business alliances. The gathering provided a premier platform for delegates to solidify collaborative ties and exchange strategic insights initiated from the pavilion. Ahead of the exhibition's conclusion, a special " Pearl Of The Orient • Victoria Harbour Cruise Party" was organized to showcase Hong Kong's unique charm as a cosmopolitan city to global guests, providing a memorable networking experience against Hong Kong's iconic skyline to formally cap off the week's successes.
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HKICEC Launches First-Ever Global Mobile Exchange Pavilion at Mobile Electronics Show
