COSTA MESA, Calif.--(BUSINESS WIRE)--Jan 28, 2025--
Experian® today released its annual Future of Fraud Forecast, revealing five emerging fraud threats that could challenge businesses and consumers in 2025. This year’s predictions show that fraudsters will continue to double down on the digital landscape and leverage Generative AI (GenAI) to commit sophisticated crimes at a rapid pace.
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According to an Experian report, half of consumers surveyed said they are concerned about conducting activities online, and companies are most worried about cybercrime (75%) and GenAI fraud and deep fakes (70%). This underscores the need for robust protections against these fraud attacks and other schemes. As fraudsters continue to evolve and leverage advanced technologies, Experian’s insights aim to help mitigate new risks. This year’s threats include:
“We know technology is accelerating fraud at a rapid pace. The challenge is clear for businesses — it’s not just about mitigating risk for known threats but anticipating what’s coming next,” said Kathleen Peters, Chief Innovation Officer for Experian North America. “Our 2025 forecast highlights the fight against fraud requires a comprehensive approach — combining advanced technology, consumer awareness and a commitment to constantly adapting to evolving threats. Businesses need to invest in innovative, multilayered fraud prevention strategies that leverage data, advanced analytics and technology to thwart risk.”
Experian’s identity verification and fraud prevention solutions helped clients avoid an estimated $15 billion in fraud losses globally last year. For more about Experian’s fraud detection solutions available on the Experian Ascend Platform™, including NeuroID’s behavioral analytics, please visit https://www.experian.com/business/solutions/fraud-management. To learn more, please register for Experian’s 2025 Fraud Trends: Disrupting GenAI in Fraud webinar scheduled for Feb. 6 at 10 a.m. PT by visiting https://us-go.experian.com/2025-fraud-predictions-webinar.
About Experian
Experian is a global data and technology company, powering opportunities for people and businesses around the world. We help to redefine lending practices, uncover and prevent fraud, simplify healthcare, deliver digital marketing solutions, and gain deeper insights into the automotive market, all using our unique combination of data, analytics and software. We also assist millions of people to realize their financial goals and help them to save time and money.
We operate across a range of markets, from financial services to healthcare, automotive, agrifinance, insurance, and many more industry segments.
We invest in talented people and new advanced technologies to unlock the power of data and innovate. As a FTSE 100 Index company listed on the London Stock Exchange (EXPN), we have a team of 22,500 people across 32 countries. Our corporate headquarters are in Dublin, Ireland. Learn more at experianplc.com.
Experian and the Experian marks used herein are trademarks or registered trademarks of Experian and its affiliates. Other product and company names mentioned herein are the property of their respective owners.
Experian's 2025 Future of Fraud Forecast (Graphic: Business Wire)
AMSTERDAM--(BUSINESS WIRE)--May 22, 2026--
Avanzanite Bioscience B.V., a rapidly growing commercial-stage European specialty pharmaceutical company focused on rare diseases, today reported that its partner, Agios Pharmaceuticals, Inc. (Nasdaq: AGIO), a commercial-stage biopharmaceutical company headquartered in Cambridge, Massachusetts focused on delivering innovative medicines for patients with rare diseases, announced that the European Commission has granted marketing authorisation for PYRUKYND® (mitapivat), an oral pyruvate kinase (PK) activator, in adults for the treatment of anaemia associated with transfusion-dependent and non-transfusion-dependent alpha- or beta-thalassaemia, with an orphan medicinal product designation.
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“Thalassaemia is a complex, chronic and multisystem disease characterised by anaemia, ineffective erythropoiesis and haemolysis, which together place a significant burden on patients, including a substantial impact on quality of life and persistent fatigue,” commented Raffaella Origa M.D., PhD., Professor of Paediatrics at University of Cagliari, Italy and President of the Italian Society of Thalassaemia and Haemoglobinopathies (SITE). “The approval of PYRUKYND in the EU represents an important step forward, introducing a new oral treatment option regardless of genotype or transfusion burden, with the potential to address key aspects of the disease, including reducing transfusion burden and improving patient outcomes.”
The EC’s decision follows the positive opinion issued by the European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP) and is based on results from the global, randomised, double-blind, placebo-controlled ENERGIZE and ENERGIZE-T Phase 3 trials. The approval of PYRUKYND for adults with thalassaemia marks its second indication in the EU, following its 2022 approval for adults with PK deficiency.
“The treatment of thalassaemia continues to place a profound burden on patients and healthcare systems,” said Antonis Kattamis M.D., Professor at the National & Kapodistrian University of Athens, Greece, and an investigator in the PYRUKYND thalassaemia Phase 3 clinical program. “An oral therapy such as PYRUKYND has the potential to transform the care of both transfusion-dependent and non-transfusion-dependent patients, and we welcome being able to provide this option in our clinical practice.”
In June 2025, Avanzanite entered into an exclusive agreement with Agios to commercialise and distribute PYRUKYND across the European Economic Area, the United Kingdom, and Switzerland. Avanzanite will continue to work closely with Agios, local health authorities and patient communities to secure access for PYRUKYND across the EU.
“Today’s approval of Agios’ first-in-class PK activator in the EU is great news for adults living with thalassaemia and we are proud and privileged to partner with Agios to distribute and commercialise this medicine in the region,” said Adam Plich, CEO and Co-Founder of Avanzanite Bioscience. “Our role now is to collaborate with local authorities, drive a successful launch, and enable broad access to PYRUKYND in this indication, helping to ensure no thalassaemia patient is left behind, across the EU.”
This milestone represents the fourth rare disease launch that Avanzanite has led, further demonstrating the strength of its pan-European commercial platform. With a ‘Champions League’ team of more than 100 rare disease professionals conducting operations spanning 32 European countries, the company is well-positioned to partner with biotech innovators to deliver transformative therapies to patients across Europe.
About Thalassaemia
Thalassaemia is a rare, inherited blood disease that affects the production of haemoglobin, the protein in red blood cells responsible for carrying oxygen throughout the body. The disease is categorised into two main types: alpha-thalassaemia and beta-thalassaemia, depending on which globin chain of the haemoglobin is affected. By disrupting haemoglobin production, thalassaemia reduces the number of circulating red blood cells and shortens their lifespan, which leads to anaemia, fatigue, and serious complications.
Some individuals with thalassaemia require regular transfusions (classified as transfusion-dependent thalassaemia), while others only need them intermittently (classified as non-transfusion-dependent thalassaemia). All patients with thalassaemia experience a significant disease burden, including comorbidities, reduced quality of life and shortened life expectancy.
About ENERGIZE and ENERGIZE-T
ENERGIZE ( NCT04770753 ) and ENERGIZE-T ( NCT04770779 ) are global, double-blind, placebo-controlled Phase 3 trials evaluating the efficacy and safety of mitapivat in adults with alpha- or beta-thalassaemia.
The ENERGIZE trial randomised 194 non-transfusion-dependent alpha- or beta-thalassaemia patients 2:1 to receive either mitapivat 100 mg twice daily or placebo. The primary endpoint was haemoglobin response, defined as an increase of ≥1.0 g/dL in average haemoglobin concentration from Week 12 through Week 24 compared with baseline. Key secondary endpoints included changes from baseline in average fatigue scores and in average haemoglobin concentration from Week 12 to Week 24. The trial also assessed safety and tolerability.
The ENERGIZE-T trial randomised 258 transfusion-dependent alpha- or beta-thalassaemia patients 2:1 to receive either mitapivat 100 mg twice daily or placebo. The primary endpoint was transfusion reduction response, defined as a ≥50% reduction in transfused red blood cell (RBC) units with a reduction of ≥2 units of RBCs transfused in any consecutive 12-week period through Week 48 compared with baseline. Several transfusion reduction measures were included as key secondary endpoints, and achievement of transfusion independence was a secondary endpoint. The trial also assessed safety and tolerability.
For each trial, patients who completed the double-blind period had the option to transition into a corresponding open-label extension period, during which all patients receive mitapivat.
About Avanzanite Bioscience
Avanzanite is redefining launches of rare disease medicines across Europe. Founded in 2022 and based in Amsterdam, the Netherlands, the company partners with biotech innovators to unlock the full commercial value of orphan medicines through a fully integrated platform spanning 32 countries. With our deep expertise in market access, we navigate Europe’s complex landscape like master chess players – ensuring no patient is left behind while delivering measurable impact and growth opportunities for alliance partners.
For more information, visit www.avanzanite.com.
Adam Plich, CEO and Co-Founder of Avanzanite Bioscience.
