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Tinnitus Research: Novel Compound AC102 Makes Constant Ear Noise Disappear in Preclinical Model

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Tinnitus Research: Novel Compound AC102 Makes Constant Ear Noise Disappear in Preclinical Model
News

News

Tinnitus Research: Novel Compound AC102 Makes Constant Ear Noise Disappear in Preclinical Model

2025-07-03 18:02 Last Updated At:18:11

ERLANGEN, Germany & BERLIN--(BUSINESS WIRE)--Jul 3, 2025--

The novel compound AC102 almost completely reversed tinnitus in a preclinical model after a single dose. At the same time, the damaged connections between the auditory nerve and inner ear sensory cells were restored. These findings were recently published in the prestigious International Journal of Molecular Sciences in a joint study conducted by Erlangen University Hospital and Berlin-based drug developer AudioCure. As there is currently no causal treatment for tinnitus, there is a high medical need.

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In the current study, AC102 was administered to the middle ear of one experimental group after acoustic trauma, while a second group received a placebo. Although both groups initially showed signs of tinnitus, they nearly disappeared in the AC102 group after five weeks – in clear contrast to the placebo group. Additionally, the AC102 group showed significantly less loss of synaptic connections between the inner ear and the auditory nerve than the placebo group. This damage is considered to be a potential cause of tinnitus: “Our results suggest regeneration of inner ear structures that are critical for tinnitus and could be an important milestone and a glimmer of hope for a causal treatment of tinnitus,” says the study's first author, Dr. Konstantin Tziridis from Erlangen University Hospital.

About two-thirds of sudden hearing loss patients also suffer from tinnitus, which persists in around 30% of cases. Although 10-15% of adults experience tinnitus, no effective causal treatment exists. AC102 has the potential to become a new treatment option. In a preclinical acoustic trauma model, it almost completely reversed sudden hearing loss. Since tinnitus often accompanies sudden hearing loss, AudioCure is investigating AC102’s potential efficacy also against tinnitus in its ongoing study. AudioCure's CEO, Dr. Reimar Schlingensiepen, emphasizes: "Constant ear noise caused by tinnitus can be even more stressful for many patients than the hearing loss itself. With AC102, we hope to eventually have an effective remedy for both conditions. This would be a great relief for patients and doctors who have no approved drug treatment available at present." AC102 has already been tested for safety and tolerability in a clinical study and is currently being examined in a Europe-wide Phase-2-study in patients for its effectiveness in sudden hearing loss and tinnitus.

In 10-20% of tinnitus cases, the noise in the ear is so severe that it significantly impairs the quality of life of those affected. (Source: AI-generated)

In 10-20% of tinnitus cases, the noise in the ear is so severe that it significantly impairs the quality of life of those affected. (Source: AI-generated)

NEW YORK (AP) — The U.S. Open, the season’s final Grand Slam, is underway in New York. Carlos Alcaraz and Aryna Sabalenka defend their singles titles, Novak Djokovic seeks a record 25th major, and Venus and Serena Williams reunite in doubles.

Aryna Sabalenka, of Belarus, serves the ball to Kamilla Rakhimova, of Uzbekistan, during the third round of the U.S. Open tennis championships Friday, Sept. 4, 2026, in New York. (AP Photo/Heather Khalifa)

Aryna Sabalenka, of Belarus, serves the ball to Kamilla Rakhimova, of Uzbekistan, during the third round of the U.S. Open tennis championships Friday, Sept. 4, 2026, in New York. (AP Photo/Heather Khalifa)

Emma Navarro, of the United States, returns the ball to Karolina Muchova, of the Czech Republic, during the third round of the U.S. Open tennis championships Friday, Sept. 4, 2026, in New York. (AP Photo/Yuki Iwamura)

Emma Navarro, of the United States, returns the ball to Karolina Muchova, of the Czech Republic, during the third round of the U.S. Open tennis championships Friday, Sept. 4, 2026, in New York. (AP Photo/Yuki Iwamura)

Carlos Alcaraz, of Spain, returns the ball to Wu Yibing, of China, during the third round of the U.S. Open tennis championships Friday, Sept. 4, 2026, in New York. (AP Photo/Kirsty Wigglesworth)

Carlos Alcaraz, of Spain, returns the ball to Wu Yibing, of China, during the third round of the U.S. Open tennis championships Friday, Sept. 4, 2026, in New York. (AP Photo/Kirsty Wigglesworth)

Ben Shelton, of the United States, serves to Denis Shapovalov, of Canada, during the third round of the U.S. Open tennis championships, early Saturday, Sept. 5, 2026, in New York. (AP Photo/Adam Hunger)

Ben Shelton, of the United States, serves to Denis Shapovalov, of Canada, during the third round of the U.S. Open tennis championships, early Saturday, Sept. 5, 2026, in New York. (AP Photo/Adam Hunger)

Tommy Paul, of the United States, right, greets Alexander Bublik, of Kazakhstan, after Paul won their match during the third round of the U.S. Open tennis championships Friday, Sept. 4, 2026, in New York. (AP Photo/Heather Khalifa)

Tommy Paul, of the United States, right, greets Alexander Bublik, of Kazakhstan, after Paul won their match during the third round of the U.S. Open tennis championships Friday, Sept. 4, 2026, in New York. (AP Photo/Heather Khalifa)

Venus Williams, left, and Serena Williams, of the United States, confer as they play against Hao-Ching Chan, of Taiwan, and Maya Joint, of Australia, during a women's doubles match at the U.S. Open tennis championships, Friday, Sept. 4, 2026, in New York. (AP Photo/Adam Hunger)

Venus Williams, left, and Serena Williams, of the United States, confer as they play against Hao-Ching Chan, of Taiwan, and Maya Joint, of Australia, during a women's doubles match at the U.S. Open tennis championships, Friday, Sept. 4, 2026, in New York. (AP Photo/Adam Hunger)

Serena Williams, right, and Venus Williams, of the United States, celebrates after a point against Hao-Ching Chan, of Taiwan, and Maya Joint, at the U.S. Open tennis championships, Friday, Sept. 4, 2026, in New York. (AP Photo/Adam Hunger)

Serena Williams, right, and Venus Williams, of the United States, celebrates after a point against Hao-Ching Chan, of Taiwan, and Maya Joint, at the U.S. Open tennis championships, Friday, Sept. 4, 2026, in New York. (AP Photo/Adam Hunger)

Marta Kostyuk, of Ukraine, reacts during the third round of the U.S. Open tennis championships against Ekaterina Alexandrova, of Russia, Friday, Sept. 4, 2026, in New York. (AP Photo/Yuki Iwamura)

Marta Kostyuk, of Ukraine, reacts during the third round of the U.S. Open tennis championships against Ekaterina Alexandrova, of Russia, Friday, Sept. 4, 2026, in New York. (AP Photo/Yuki Iwamura)

Oleksandra Oliynykova, of Ukraine, reacts during the second round of the U.S. Open tennis championships against Alexandra Eala, of the Philippines, Thursday, Sept. 3, 2026, in New York. (AP Photo/Seth Wenig)

Oleksandra Oliynykova, of Ukraine, reacts during the second round of the U.S. Open tennis championships against Alexandra Eala, of the Philippines, Thursday, Sept. 3, 2026, in New York. (AP Photo/Seth Wenig)

Madison Keys, of the United States, celebrates after she defeated Anna Bondar, of Hungary, during the second round of the U.S. Open tennis championships Thursday, Sept. 3, 2026, in New York. (AP Photo/Seth Wenig)

Madison Keys, of the United States, celebrates after she defeated Anna Bondar, of Hungary, during the second round of the U.S. Open tennis championships Thursday, Sept. 3, 2026, in New York. (AP Photo/Seth Wenig)

Alexandra Eala, of the Philippines, returns the ball to Oleksandra Oliynykova, of Ukraine, during the second round of the U.S. Open tennis championships Thursday, Sept. 3, 2026, in New York. (AP Photo/Seth Wenig)

Alexandra Eala, of the Philippines, returns the ball to Oleksandra Oliynykova, of Ukraine, during the second round of the U.S. Open tennis championships Thursday, Sept. 3, 2026, in New York. (AP Photo/Seth Wenig)

Coco Gauff, of the United States, eyes a return to Paula Badosa, of Spain, during the second round of the U.S. Open tennis championships, Thursday, Sept. 3, 2026, in New York. (AP Photo/Frank Franklin II)

Coco Gauff, of the United States, eyes a return to Paula Badosa, of Spain, during the second round of the U.S. Open tennis championships, Thursday, Sept. 3, 2026, in New York. (AP Photo/Frank Franklin II)

Katerina Siniakova, of the Czech Republic, returns the ball to Naomi Osaka, of Japan, during the second round of the U.S. Open tennis championships against Thursday, Sept. 3, 2026, in New York. (AP Photo/Andres Kudacki)

Katerina Siniakova, of the Czech Republic, returns the ball to Naomi Osaka, of Japan, during the second round of the U.S. Open tennis championships against Thursday, Sept. 3, 2026, in New York. (AP Photo/Andres Kudacki)

Ben Shelton, of the United States, returns the ball to Hubert Hurkacz, of Poland, during the second round of the U.S. Open tennis championships Wednesday, Sept. 2, 2026, in New York. (AP Photo/Kirsty Wigglesworth)

Ben Shelton, of the United States, returns the ball to Hubert Hurkacz, of Poland, during the second round of the U.S. Open tennis championships Wednesday, Sept. 2, 2026, in New York. (AP Photo/Kirsty Wigglesworth)

Marta Kostyuk, of Ukraine, returns the ball to Sloane Stephens, of the United States, during the second round of the U.S. Open tennis championships Wednesday, Sept. 2, 2026, in New York. (AP Photo/Yuki Iwamura)

Marta Kostyuk, of Ukraine, returns the ball to Sloane Stephens, of the United States, during the second round of the U.S. Open tennis championships Wednesday, Sept. 2, 2026, in New York. (AP Photo/Yuki Iwamura)

Daniil Medvedev, of Russia, returns the ball to Sebastian Gorzny, of the United States, during the second round of the U.S. Open tennis championships Wednesday, Sept. 2, 2026, in New York. (AP Photo/Yuki Iwamura)

Daniil Medvedev, of Russia, returns the ball to Sebastian Gorzny, of the United States, during the second round of the U.S. Open tennis championships Wednesday, Sept. 2, 2026, in New York. (AP Photo/Yuki Iwamura)

Rain drops are visible on a glass at the Grandstand stadium during the U.S. Open tennis championships Wednesday, Sept. 2, 2026, in New York. (AP Photo/Seth Wenig)

Rain drops are visible on a glass at the Grandstand stadium during the U.S. Open tennis championships Wednesday, Sept. 2, 2026, in New York. (AP Photo/Seth Wenig)

Jessica Pegula, of the United States, serves the ball to Sofia Kenin, of the United States, during the second round of the U.S. Open tennis championships Wednesday, Sept. 2, 2026, in New York. (AP Photo/Kirsty Wigglesworth)

Jessica Pegula, of the United States, serves the ball to Sofia Kenin, of the United States, during the second round of the U.S. Open tennis championships Wednesday, Sept. 2, 2026, in New York. (AP Photo/Kirsty Wigglesworth)

Lucrezia Stefanini, of Italy, competes against Dayana Yastremska, of Ukraine, during the first round of the U.S. Open tennis championships, Sunday, Aug. 30, 2026, in New York. (AP Photo/Andres Kudacki)

Lucrezia Stefanini, of Italy, competes against Dayana Yastremska, of Ukraine, during the first round of the U.S. Open tennis championships, Sunday, Aug. 30, 2026, in New York. (AP Photo/Andres Kudacki)

Marta Kostyuk, of Ukraine, reacts following a match against Storm Hunter, of Australia, during the first round of the U.S. Open tennis championships, Sunday, Aug. 30, 2026, in New York. (AP Photo/Andres Kudacki)

Marta Kostyuk, of Ukraine, reacts following a match against Storm Hunter, of Australia, during the first round of the U.S. Open tennis championships, Sunday, Aug. 30, 2026, in New York. (AP Photo/Andres Kudacki)

Andrey Rublev, of Russia, serves the ball to Otto Virtanen, of Finland, during the first round of the U.S. Open tennis championships Monday, Aug. 31, 2026, in New York. (AP Photo/Yuki Iwamura)

Andrey Rublev, of Russia, serves the ball to Otto Virtanen, of Finland, during the first round of the U.S. Open tennis championships Monday, Aug. 31, 2026, in New York. (AP Photo/Yuki Iwamura)

Novak Djokovic, of Serbia, drops a ball as he competes against Mariano Navone, of Argentina, during the first round of the U.S. Open tennis championships Sunday, Aug. 30, 2026, in New York. (AP Photo/Frank Franklin II)

Novak Djokovic, of Serbia, drops a ball as he competes against Mariano Navone, of Argentina, during the first round of the U.S. Open tennis championships Sunday, Aug. 30, 2026, in New York. (AP Photo/Frank Franklin II)

Venus Williams, of the United States, reacts during her first round match against compatriot Sofia Kenin at the U.S. Open tennis championships, Monday, Aug. 31, 2026, in New York. (AP Photo/Frank Franklin II)

Venus Williams, of the United States, reacts during her first round match against compatriot Sofia Kenin at the U.S. Open tennis championships, Monday, Aug. 31, 2026, in New York. (AP Photo/Frank Franklin II)

Ball persons wipe the floor during a break in play between Novak Djokovic, of Serbia, and Mariano Navone, of Argentina, during the first round of the U.S. Open tennis championships Sunday, Aug. 30, 2026, in New York. (AP Photo/Frank Franklin II)

Ball persons wipe the floor during a break in play between Novak Djokovic, of Serbia, and Mariano Navone, of Argentina, during the first round of the U.S. Open tennis championships Sunday, Aug. 30, 2026, in New York. (AP Photo/Frank Franklin II)

Mariano Navone, of Argentina, celebrates after he defeated Novak Djokovic, of Serbia, during the first round of the U.S. Open tennis championships Sunday, Aug. 30, 2026, in New York. (AP Photo/Frank Franklin II)

Mariano Navone, of Argentina, celebrates after he defeated Novak Djokovic, of Serbia, during the first round of the U.S. Open tennis championships Sunday, Aug. 30, 2026, in New York. (AP Photo/Frank Franklin II)

Novak Djokovic, of Serbia, reacts on the court during the first round of the U.S. Open tennis championships against Mariano Navone, of Argentina, Sunday, Aug. 30, 2026, in New York. (AP Photo/Frank Franklin II)

Novak Djokovic, of Serbia, reacts on the court during the first round of the U.S. Open tennis championships against Mariano Navone, of Argentina, Sunday, Aug. 30, 2026, in New York. (AP Photo/Frank Franklin II)

Tara Djokovic, right, reacts with her mom Jelena Djokovic center, and brother Stefan Djokovic, left, as her dad, Novak Djokovic, of Serbia, competes against Mariano Navone, of Argentina, during the first round of the U.S. Open tennis championships Sunday, Aug. 30, 2026, in New York. (AP Photo/Frank Franklin II)

Tara Djokovic, right, reacts with her mom Jelena Djokovic center, and brother Stefan Djokovic, left, as her dad, Novak Djokovic, of Serbia, competes against Mariano Navone, of Argentina, during the first round of the U.S. Open tennis championships Sunday, Aug. 30, 2026, in New York. (AP Photo/Frank Franklin II)

Aryna Sabalenka, of Belarus, follows through on a shot to Camila Osorio, of Colombia, during the first round of the U.S. Open tennis championships, Monday, Aug. 31, 2026, in New York. (AP Photo/Seth Wenig)

Aryna Sabalenka, of Belarus, follows through on a shot to Camila Osorio, of Colombia, during the first round of the U.S. Open tennis championships, Monday, Aug. 31, 2026, in New York. (AP Photo/Seth Wenig)

Aryna Sabalenka, of Belarus, returns the ball to Camila Osorio, of Colombia, during the first round of the U.S. Open tennis championships, Monday, Aug. 31, 2026, in New York. (AP Photo/Seth Wenig)

Aryna Sabalenka, of Belarus, returns the ball to Camila Osorio, of Colombia, during the first round of the U.S. Open tennis championships, Monday, Aug. 31, 2026, in New York. (AP Photo/Seth Wenig)

Arthur Fils, of France, lunges to return the ball to Stefanos Tsitsipas, of Greece, during the first round of the U.S. Open tennis championships, Monday, Aug. 31, 2026, in New York. (AP Photo/Kirsty Wigglesworth)

Arthur Fils, of France, lunges to return the ball to Stefanos Tsitsipas, of Greece, during the first round of the U.S. Open tennis championships, Monday, Aug. 31, 2026, in New York. (AP Photo/Kirsty Wigglesworth)

Fans react as they watch Venus Williams, of the United States, play compatriot Sofia Kenin during their first round match at the U.S. Open tennis championships, Monday, Aug. 31, 2026, in New York. (AP Photo/Frank Franklin II)

Fans react as they watch Venus Williams, of the United States, play compatriot Sofia Kenin during their first round match at the U.S. Open tennis championships, Monday, Aug. 31, 2026, in New York. (AP Photo/Frank Franklin II)

Carlos Alcaraz, of Spain, returns the ball to Roman Safiullin, of Russia, during the first round of the U.S. Open tennis championships, Monday, Aug. 31, 2026, in New York. (AP Photo/Seth Wenig)

Carlos Alcaraz, of Spain, returns the ball to Roman Safiullin, of Russia, during the first round of the U.S. Open tennis championships, Monday, Aug. 31, 2026, in New York. (AP Photo/Seth Wenig)

The Grandstand stadium sits empty during a rain delay at the U.S. Open tennis championships Tuesday, Sept. 1, 2026, in New York. (AP Photo/Kirsty Wigglesworth)

The Grandstand stadium sits empty during a rain delay at the U.S. Open tennis championships Tuesday, Sept. 1, 2026, in New York. (AP Photo/Kirsty Wigglesworth)

Naomi Osaka, of Japan, arrives to compete against Anastasia Zakharova, of Russia, during the first round of the U.S. Open tennis championships Monday, Aug. 31, 2026, in New York. (AP Photo/Adam Hunger)

Naomi Osaka, of Japan, arrives to compete against Anastasia Zakharova, of Russia, during the first round of the U.S. Open tennis championships Monday, Aug. 31, 2026, in New York. (AP Photo/Adam Hunger)

Jasmine Paolini, of Italy, reacts during the first round of the U.S. Open tennis championships against Veronika Erjavec, of Slovenia, Sunday, Aug. 30, 2026, in New York. (AP Photo/Yuki Iwamura)

Jasmine Paolini, of Italy, reacts during the first round of the U.S. Open tennis championships against Veronika Erjavec, of Slovenia, Sunday, Aug. 30, 2026, in New York. (AP Photo/Yuki Iwamura)

Tennis fans watch a match between Miomir Kecmanovic, of Serbia, and Denis Shapovalov, of Canada, during the first round of the U.S. Open tennis championships, Sunday, Aug. 30, 2026, in New York. (AP Photo/Adam Hunger)

Tennis fans watch a match between Miomir Kecmanovic, of Serbia, and Denis Shapovalov, of Canada, during the first round of the U.S. Open tennis championships, Sunday, Aug. 30, 2026, in New York. (AP Photo/Adam Hunger)

Denis Shapovalov, of Canada, reacts during a match against Miomir Kecmanovic, of Serbia, during the first round of the U.S. Open tennis championships, Sunday, Aug. 30, 2026, in New York. (AP Photo/Adam Hunger)

Denis Shapovalov, of Canada, reacts during a match against Miomir Kecmanovic, of Serbia, during the first round of the U.S. Open tennis championships, Sunday, Aug. 30, 2026, in New York. (AP Photo/Adam Hunger)

Spectators ask for autographs from Tommy Paul, of the United States, after he defeated Coleman Wong, of Hong Kong, during the first round of the U.S. Open tennis championships Sunday, Aug. 30, 2026, in New York. (AP Photo/Yuki Iwamura)

Spectators ask for autographs from Tommy Paul, of the United States, after he defeated Coleman Wong, of Hong Kong, during the first round of the U.S. Open tennis championships Sunday, Aug. 30, 2026, in New York. (AP Photo/Yuki Iwamura)

Lucrezia Stefanini, of Italy, competes against Dayana Yastremska, of Ukraine, during the first round of the U.S. Open tennis championships, Sunday, Aug. 30, 2026, in New York. (AP Photo/Andres Kudacki)

Lucrezia Stefanini, of Italy, competes against Dayana Yastremska, of Ukraine, during the first round of the U.S. Open tennis championships, Sunday, Aug. 30, 2026, in New York. (AP Photo/Andres Kudacki)

Hugo Gaston, of France, returns the ball to Daniil Medvedev, of Russia, during the first round of the U.S. Open tennis championships Sunday, Aug. 30, 2026, in New York. (AP Photo/Kirsty Wigglesworth)

Hugo Gaston, of France, returns the ball to Daniil Medvedev, of Russia, during the first round of the U.S. Open tennis championships Sunday, Aug. 30, 2026, in New York. (AP Photo/Kirsty Wigglesworth)

Luca van Assche, of France, returns the ball to Cameron Norrie, of Britain, during the first round of the U.S. Open tennis championships, Sunday, Aug. 30, 2026, in New York. (AP Photo/Andres Kudacki)

Luca van Assche, of France, returns the ball to Cameron Norrie, of Britain, during the first round of the U.S. Open tennis championships, Sunday, Aug. 30, 2026, in New York. (AP Photo/Andres Kudacki)

Spectators walk around the grounds of the USTA Billie Jean King National Tennis Center during the first round of the U.S. Open tennis championships Sunday, Aug. 30, 2026, in New York. (AP Photo/Frank Franklin II)

Spectators walk around the grounds of the USTA Billie Jean King National Tennis Center during the first round of the U.S. Open tennis championships Sunday, Aug. 30, 2026, in New York. (AP Photo/Frank Franklin II)

Sho Shimabukuro, of Japan, returns the ball to Arthur Rinderknech, of France, during the first round of the U.S. Open tennis championships, Sunday, Aug. 30, 2026, in New York. (AP Photo/Andres Kudacki)

Sho Shimabukuro, of Japan, returns the ball to Arthur Rinderknech, of France, during the first round of the U.S. Open tennis championships, Sunday, Aug. 30, 2026, in New York. (AP Photo/Andres Kudacki)

Daniil Medvedev, of Russia, celebrates after he defeated Hugo Gaston, of France, during the first round of the U.S. Open tennis championships Sunday, Aug. 30, 2026, in New York. (AP Photo/Kirsty Wigglesworth)

Daniil Medvedev, of Russia, celebrates after he defeated Hugo Gaston, of France, during the first round of the U.S. Open tennis championships Sunday, Aug. 30, 2026, in New York. (AP Photo/Kirsty Wigglesworth)

Jasmine Paolini, of Italy, returns the ball to Veronika Erjavec, of Slovenia, during the first round of the U.S. Open tennis championships Sunday, Aug. 30, 2026, in New York. (AP Photo/Yuki Iwamura)

Jasmine Paolini, of Italy, returns the ball to Veronika Erjavec, of Slovenia, during the first round of the U.S. Open tennis championships Sunday, Aug. 30, 2026, in New York. (AP Photo/Yuki Iwamura)

Jessica Pegula, of the United States, right, embraces Elena-Gabriela Ruse, of Romania, after Pegula won the first round of the U.S. Open tennis championships Sunday, Aug. 30, 2026, in New York. (AP Photo/Kirsty Wigglesworth)

Jessica Pegula, of the United States, right, embraces Elena-Gabriela Ruse, of Romania, after Pegula won the first round of the U.S. Open tennis championships Sunday, Aug. 30, 2026, in New York. (AP Photo/Kirsty Wigglesworth)

Kamilla Rakhimova, of Uzbekistan, serves the ball to Barbora Krejcikova, of the Czech Republic, during the first round of the U.S. Open tennis championships Sunday, Aug. 30, 2026, in New York. (AP Photo/Kirsty Wigglesworth)

Kamilla Rakhimova, of Uzbekistan, serves the ball to Barbora Krejcikova, of the Czech Republic, during the first round of the U.S. Open tennis championships Sunday, Aug. 30, 2026, in New York. (AP Photo/Kirsty Wigglesworth)

Daniil Medvedev, of Russia, serves the ball to Hugo Gaston, of France, top, during the first round of the U.S. Open tennis championships at Arthur Ashe Stadium on Sunday, Aug. 30, 2026, in New York. (AP Photo/Kirsty Wigglesworth)

Daniil Medvedev, of Russia, serves the ball to Hugo Gaston, of France, top, during the first round of the U.S. Open tennis championships at Arthur Ashe Stadium on Sunday, Aug. 30, 2026, in New York. (AP Photo/Kirsty Wigglesworth)

Marta Kostyuk, of Ukraine, reacts following a match against Storm Hunter, of Australia, during the first round of the U.S. Open tennis championships, Sunday, Aug. 30, 2026, in New York. (AP Photo/Andres Kudacki)

Marta Kostyuk, of Ukraine, reacts following a match against Storm Hunter, of Australia, during the first round of the U.S. Open tennis championships, Sunday, Aug. 30, 2026, in New York. (AP Photo/Andres Kudacki)

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