Dreams initiative empowers workers' education

BEIJING, Sept. 30, 2025 /PRNewswire/ -- A report from China Daily:

The Study for Dreams Initiative, a collaborative program launched in 2016 by the Ministry of Education and the All-China Federation of Trade Unions, has been significantly upgraded this year to enhance the academic qualifications and skills of industrial workers.

Initially focused on migrant workers, the initiative now extends its reach to all industrial workers, emphasizing both academic and non-academic education, and integrating academic learning with skill development.

This expansion is shaped by comprehensive guidelines jointly issued by the ministry and the ACFTU, as well as the Ministry of Human Resources and Social Security and the All-China Federation of Industry and Commerce.

By 2030, the program aims to establish at least 300 projects dedicated to education and capacity building for industrial workers, fund at least 3 million eligible workers — including more than 2 million migrant workers — and inspire a culture of lifelong learning.

This effort seeks to enhance workers' qualifications and skills, contributing to the development of a first-class team of industrial technicians.

The upgraded initiative focuses on integrating resources from multiple parties, emphasizing coordinated efforts in organizational support, funding subsidies, and talent training. It also encourages universities, vocational colleges, craftsman academies, and enterprises to share high-quality educational resources, according to the All-China Federation of Trade Unions.

As of June 2024, more than 500 universities across China have participated, with trade unions at all levels investing over 1.1 billion yuan ($154 million) to help more than 2.4 million migrant workers upgrade their academic qualifications and skills.

Yuan Caifeng, who grew up in a small village in Anhui province, is one of the beneficiaries. After leaving junior high school to work, she joined an electronics company in Wuxi, Jiangsu province, as an apprentice in 2004.

"I knew improving my education and skills was important, but with a busy work schedule and limited finances, continuing my studies seemed out of reach," she recalled.

In 2017, Yuan discovered the Study for Dreams Initiative, which offered a blended online-offline learning model that fit her schedule. The Wuxi Federation of Trade Unions also provided scholarships to subsidize tuition for outstanding students.

Yuan enrolled in the human resources school at Jiangnan University, which opened new opportunities for her.

"This experience opened a new world for me," she said. "For example, when the company faced high staff turnover, I initially thought it was just due to low salaries. But through studies, I realized optimizing the salary structure and improving incentive mechanisms are key to boosting employee motivation."

Jiangsu has been allocating special funds for the initiative since 2017, increasing its budget from 7.5 million yuan to 40 million yuan.

"We continue to expand coverage, with a focus on migrant workers and new forms of labor," said an official at the Jiangsu Federation of Trade Unions.

This year, the provincial federation plans to subsidize 60,000 migrant workers and front-line employees with 60 million yuan.

At the Fengqi Road branch of SF Express in Hangzhou, Zhejiang­ province, operation supervisor He Xiujie, who has been in the industry for 12 years, exemplifies the initiative's effect.

In 2018, he enrolled in the economic information management program at Zhejiang University of Science and Technology, focusing on improving business knowledge and management thinking. After graduating with an associate degree four years later, he joined the supervisor reserve team and received three months of full-time training.

"We have built a practical training platform and adopted a work-study alternation system, integrating on-the-job practice with coursework," said Ma Hongfei, general manager of SF Express Zhejiang.

This system bridges the career ladder from courier to station manager and district manager, while integrating the development pathway that encompasses skill enhancement, qualification certification, and professional title assessment, ultimately forging a robust link between academic credentials and job roles, he noted.

The company has seen more than 400 employees upgrade their education, with many transitioning from front-line couriers to grassroots managers.

In Chongqing, the Study for Dreams Initiative has been particularly transformative. In a classroom at Chongqing Electric Power College, craftsman tutor Chen Chong captivates students with his detailed explanation of switchgear structure and operation.

This session is part of the "corporate expert in the classroom" course, a component of the Study for Dreams Initiative. Chen is among the pioneering craftsman tutors in Chongqing's industry-education integration alliance within the electric power sector.

Several years ago, while serving as a centralized control operation inspector at Huadian Power International's Fengjie power plant, Chen encountered university educators for the first time during an academic upgrade class. This class was a collaborative effort between Chongqing Electric Power College and the power plant.

Chen, alongside 40 colleagues from various departments such as fuel, operations, and maintenance, enrolled as part of the inaugural group of students.

Under the guidance of university teachers, Chen helped address challenges faced by the power grid in northeastern Chongqing and wrote his graduation thesis on the topic.

The industry-education integration alliance in Chongqing's electric power industry has pioneered a craftsman tutor-plus-full-time-teacher model, integrating scientific research with industry. Over the past two years, the alliance has obtained 505 patents and transformed 348 innovative achievements, helping more than 800 workers upgrade their educational degrees and training more than 300,000 on-the-job workers.

"This reform has been effective and is gradually expanding to other industries in Chongqing," said Yu Jiping, Party secretary and vice-chairman of the Chongqing Federation of Trade Unions.

This year, the city federation has led the establishment of industry-education integration alliances in sectors such as intelligent connected new energy vehicles, smart equipment and manufacturing, gas geology, and chemical pharmaceuticals, linking 100 universities with 1,000 key enterprises in Sichuan and Chongqing.

Within three years, these alliances aim to help 10,000 industrial workers advance their education and 1 million others enhance their skills.

** The press release content is from PR Newswire. Bastille Post is not involved in its creation. **

Dreams initiative empowers workers' education

HIGHLIGHTS

• Following an interim data review of the Cohort Expansion Phase (Phase II) of the SECuRE trial, the Safety Review Committee (SRC) confirms the trial will continue with no modifications to the protocol.

Patient population

• With the SECuRE trial continuing to recruit, a total of nine participants who had evaluable data by the 25^th of November 2025 were included in the interim assessment by the SRC, with the majority of participants receiving at least two cycles of 8 GBq of ⁶⁷Cu-SAR-bisPSMA each by the data cut-off date.
• Seven participants received ⁶⁷Cu-SAR-bisPSMA and two participants were treated with a combination of ⁶⁷Cu-SAR-bisPSMA with enzalutamide.
• Most participants were heavily pre-treated (with 55.6% having received more than 5 previous anti-cancer regimens) and had bone metastasis (66.7%).

Safety

• The safety profile of ⁶⁷Cu-SAR-bisPSMA remains favourable with most related adverse events (AEs) in the Cohort Expansion to date being Grade 1 or 2. The most common AEs were nausea and lymphopenia (observed in 33.3% of participants, for each AE).

Efficacy

• Six participants had at least two prostate specific antigen (PSA) results following ⁶⁷Cu-SAR-bisPSMA administration, with all showing a decrease in PSA. Of those, four participants (66.7%) thus far had a reduction of more than 50% in PSA (PSA50) and two participants (33.3%) had a reduction of more than 80% (PSA80).
• One participant who presented with bone metastasis at enrolment achieved undetectable PSA with no prostate cancer detected by computed tomography (CT) or bone scan following ⁶⁷Cu-SAR-bisPSMA treatment. The participant reported having excellent quality of life following the treatment.

Next Steps

• The SECuRE trial will continue enrolment into the Cohort Expansion Phase with planned completion of recruitment in 2026. Phase III registrational trial planning ongoing based on data generated to date.

SYDNEY, Jan. 15, 2026 /PRNewswire/ -- Clarity Pharmaceuticals (ASX: CU6) ("Clarity" or "Company"), a clinical-stage radiopharmaceutical company with a mission to develop next-generation products that improve treatment outcomes for patients with cancer, is pleased to share a number of updates on the SECuRE trial following an SRC meeting. The SRC has recommended that the trial continue with the Cohort Expansion Phase (Phase II) as planned with no modifications to the protocol. The interim results assessed by the SRC were collected from nine participants enrolled in the cohort that had evaluable data by the cut-off date of the 25^th of November 2025 and continue to show promising efficacy and a favourable safety profile of ⁶⁷Cu-SAR-bisPSMA.

The majority of the nine participants had bone metastasis at enrolment (66.7%) and received multiple lines of previous treatments (more than 5 previous anti-cancer regimens, 55.6%). Median PSA prior to ⁶⁷Cu-SAR-bisPSMA treatment was 18.9 ng/mL (range 1.5-30.2 ng/mL). Six out of these nine participants received at least 2 cycles of 8 GBq of ⁶⁷Cu-SAR-bisPSMA each, with two of them also receiving concomitant enzalutamide.

Of the nine participants included in this SRC analysis, six had at least two PSA results following their ⁶⁷Cu-SAR-bisPSMA treatment by the data cut-off date. Of these six participants, thus far four (66.7%) showed reductions in PSA of 50% or more (PSA50) and two (33.3%) showed reductions of 80% or more (PSA80).

The safety profile of ⁶⁷Cu-SAR-bisPSMA remains favourable in the Cohort Expansion, with the majority of related AEs being Grade 1 or 2. The most common related AEs were nausea and lymphopenia (observed in three out of nine participants [33.3%], for each AE). The only AE that was Grade 3 or above was lymphopenia observed in three participants, some of whom had bone metastasis at baseline and/or had received multiple lines of therapy, including taxane and an investigational agent, prior to enrolment in the SECuRE study. There have been no overall renal toxicity or electrocardiogram (ECG) changes observed in these participants. In the combination enzalutamide arm, no new AEs (or worsening of AEs) related to ⁶⁷Cu-SAR-bisPSMA have been observed to date.

Trial participant with no detectable disease after 3 cycles of ⁶⁷Cu-SAR-bisPSMA

One of the participants in the Cohort Expansion was a 64-year-old man with bone metastases and baseline PSA of 5.4 ng/mL prior to entering the SECuRE study. Following his first cycle of ⁶⁷Cu-SAR-bisPSMA, this participant showed a dramatic 95.2% reduction in PSA. He went on to receive 2 more cycles of ⁶⁷Cu-SAR-bisPSMA and achieved undetectable PSA levels. In a follow-up bone scan and CT no metastatic disease was observed. This participant only exhibited mild (Grade 1) related AEs, most of which were gastrointestinal events, with no haematological or renal AEs observed. The participant reported having excellent quality of life following the treatment.

The interim data from this Phase II continues to confirm the favourable safety profile and promising efficacy seen in previous cohorts of the SECuRE trial^[1] and supports the continuation of the trial with the aim to progress to a registrational Phase III study.

Clarity's Executive Chairperson, Dr Alan Taylor, commented, "SAR-bisPSMA continues generating world-class data in both theranostic and diagnostic trials. The combination of the optimised dimer 'bis' structure with the benefits of copper isotopes, enabled by the proprietary sarcophagine technology, is proving to have created a product that is here to challenge the current treatment and diagnostic paradigms in radiopharmaceuticals.

"We have already seen a glimpse of the effects of ⁶⁷Cu-SAR-bisPSMA through our Dose Escalation cohorts with additional and similar data being generated in the Cohort Expansion phase, demonstrating once again excellent efficacy and safety results of ⁶⁷Cu-SAR-bisPSMA.

"All of the participants with evaluable data treated in the Phase II to date have shown declines in PSA, with the majority showing PSA decreases of more than 50% and mostly having only mild or moderate AEs. Most of these patients have been treated with more than 5 systemic treatment regiments and had bone metastasis prior to entering the SECuRE study. Although the number of participants with evaluable data to date is small, it is incredible to see yet another extraordinary case where a patient who had bone metastasis prior to entering the study achieved undetectable PSA following ⁶⁷Cu-SAR-bisPSMA treatment, with no disease observed by anatomical and molecular imaging at the last assessments. This participant only experienced mild, transient AEs, most being gastrointestinal, and has reported having excellent quality of life following the treatment.

"Importantly, the work we have undertaken during the Dose Escalation Phase is now continuing to provide a strong foundation for us as we look ahead at protocol development and dosing for our Phase III clinical trial and commercialisation. As the participant numbers continue to increase with the trial enrollment, we continue to see very promising responses over and over again, giving us more confidence about the future of this product and its potential for commercialisation in metastatic castration-resistant prostate cancer (mCRPC). With three Fast Track Designations for the SAR-bisPSMA product and positive interactions with the US Food and Drug Administration (FDA) to date, we are working towards bringing this agent to clinicians and their patients around the world through the entirety of the prostate cancer journey, from first diagnosis to late-stage disease. All of these indications, being imaging in pre-definitive therapy and biochemical recurrence, as well as therapy in mCRPC, are blockbuster markets individually for prostate-specific membrane antigen (PSMA) targeted products, with an estimated combined market value of approximately US$10-15 billion by 2030. We are committed to continuing the development of this product, aiming to bring improved diagnostic and treatment options for prostate cancer in various stages of their disease."

About the SECuRE trial

The SECuRE trial (NCT04868604)^[2] is a Phase I/IIa theranostic trial for identification and treatment of participants with PSMA-expressing mCRPC using ⁶⁴Cu/⁶⁷Cu-SAR-bisPSMA. ⁶⁴Cu-SAR-bisPSMA is used to visualise PSMA-expressing lesions and select candidates for subsequent ⁶⁷Cu-SAR-bisPSMA therapy. The trial is a multi-centre, single arm, dose escalation study with a cohort expansion involving approximately 54 participants in the US. The overall aim of the trial is to determine the safety and efficacy of ⁶⁷Cu-SAR-bisPSMA for the treatment of prostate cancer.

The SECuRE trial consists of the Dose Escalation (Phase I) and Cohort Expansion (Phase II) Phases. Based on the data from the Dose Escalation Phase, which demonstrated a favourable safety profile and efficacy of ⁶⁷Cu-SAR-bisPSMA, the SECuRE trial progressed to the Cohort Expansion (Phase II) at an 8 GBq dose level as per the SRC recommendation (up to 6 cycles per patient in total)^[3].

Cohort 2 of the Dose Escalation phase of the trial, where participants were dosed with 8 GBq of ⁶⁷Cu-SAR-bisPSMA, demonstrated a very low rate of related AEs while all three participants achieved PSA declines of 80% or more (PSA80)^[1]. The Dose Escalation Phase also showed high PSA response rates of the mCRPC in the pre-chemotherapy setting with a favourable safety profile: 92% of pre-chemotherapy participants (12/13) demonstrated PSA drops greater than 35%, PSA reductions greater than 50% were reached in 61.5% (8/13) of participants, and reductions of 80% or more were achieved in 46.2% (6/13) of participants^[1]. These results supported the progress of the trial to its Cohort Expansion Phase using 8 GBq multi-dose in participants who had not received chemotherapy in the mCRPC setting.

Recruitment is currently ongoing into the Cohort Expansion Phase which will include 24 participants. A subset of participants will be treated with the combination of 8 GBq of ⁶⁷Cu-SAR-bisPSMA with enzalutamide (androgen receptor pathway inhibitor [ARPI]), in line with the positive results from the Enza-p trial^[4] and previous discussions with and advice from key global medical experts in the field of prostate cancer, including the Company's Clinical Advisory Board members, Prof Louise Emmett and Prof Oliver Sartor, as well as the SRC.

About SAR-bisPSMA

SAR-bisPSMA derives its name from the word "bis", which reflects a novel approach of connecting two PSMA-targeting agents to Clarity's proprietary sarcophagine (SAR) technology that securely holds copper isotopes inside a cage-like structure, called a chelator. Unlike other commercially available chelators, the SAR technology prevents copper leakage into the body. SAR-bisPSMA is a Targeted Copper Theranostic (TCT) that can be used with isotopes of copper-64 (Cu-64 or ⁶⁴Cu) for imaging and copper-67 (Cu-67 or ⁶⁷Cu) for therapy.

⁶⁷Cu-SAR-bisPSMA and ⁶⁴Cu-SAR-bisPSMA are unregistered products. The safety and efficacy of ⁶⁷Cu-SAR-bisPSMA and ⁶⁴Cu-SAR-bisPSMA have not been assessed by health authorities such as the US FDA or the Therapeutic Goods Administration (TGA). There is no guarantee that these products will become commercially available.

About Prostate Cancer

Prostate cancer is the second most common cancer diagnosed in men globally and the fifth leading cause of cancer death in men worldwide^[5]. Prostate cancer is the second-leading causes of cancer death in American men. The American Cancer Institute estimates in 2025 there will be about 313,780 new cases of prostate cancer in the US and around 35,770 deaths from the disease^[6].

About Clarity Pharmaceuticals

Clarity is a clinical stage radiopharmaceutical company focused on the treatment of serious diseases. The Company is a leader in innovative radiopharmaceuticals, developing TCTs based on its SAR Technology Platform for the treatment of cancers.

www.claritypharmaceuticals.com

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