HAYWARD, Calif.--(BUSINESS WIRE)--Sep 30, 2025--
RefleXion Medical, an external‑beam theranostic oncology company, today announced first results from the PREMIER Registry ( NCT05406167 ) evaluating its SCINTIX ® biology-guided radiotherapy, or BgRT, platform in patients with lung and bone tumors. The findings, presented at the 2025 ASTRO Annual Meeting, showed local control of 100 percent at nine months post-treatment with no reported Grade 2 or higher adverse events. The data represent the first prospective, multi-institutional evidence of SCINTIX therapy’s clinical impact.
This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20250930703119/en/
“The PREMIER Registry findings mark a milestone for our field,” said Sean Shirvani, M.D., MPH, chief medical officer at RefleXion. “We are beginning to see the clinical translation of a technology that can autonomously guide radiation based on real-time biology. Achieving 100% local control in both lung and bone tumors with imaging up to nine months after treatment, without significant toxicity, represents an important step forward in expanding the reach of radiotherapy for patients with advanced cancer.”
By Feb. 25, 2025, five cancer centers had enrolled 45 patients in the registry, with 28 providing follow-up imaging for analysis. Fifteen patients were treated for lung tumors, including early-stage and metastatic disease, and 13 for bone metastases. The median patient age was 69.5 years, with 39% female.
Across 39 follow-up scans, investigators reported a local control rate – defined as complete response (CR), partial response (PR), or stable disease (SD) – of 100% across available follow-up imaging. Tumor response rates (CR+PR) were 41% overall, including 47% for bone metastases and 35% for lung tumors. No Grade 2 or higher treatment-related adverse events were observed.
RefleXion plans to expand registry enrollment and continue long-term follow-up to strengthen the dataset and evaluate correlations between treatment parameters, imaging metrics and patient outcomes.
These early results underscore RefleXion’s goal of establishing SCINTIX therapy as a first-in-class treatment option for both localized and metastatic disease. As the registry grows, the company expects the evidence to further support BgRT’s integration into routine cancer care.
RefleXion (booth #1433) is also presenting early results characterizing performance of its future, next-generation platform 1 that offers a 20-fold increase in PET sensitivity, which may increase patient eligibility for SCINTIX therapy. Presentations will be held every 30 minutes in the RefleXion booth during exhibit hours.
About RefleXion Medical
RefleXion is a privately held theranostic oncology company located in Hayward, Calif., commercializing SCINTIX biology‑guided radiotherapy, a novel therapy that uses a single radiotracer injection to turn cancer cells into real‑time biological beacons to guide external‑beam radiotherapy. SCINTIX therapy is FDA‑cleared for FDG‑guided treatment of lung and bone tumors, including metastases, and is under investigation for additional tracers and indications. The RefleXion X1 platform is also cleared for conventional image‑guided radiotherapy for solid tumors anywhere in the body. For more information, visit www.reflexion.com.
The RefleXion X1 is the only dual-treatment modality platform that uses signals from injected radiotracers to autonomously direct radiation to solid tumors.
BRISBANE, Australia (AP) — Australia took a 44-run first-innings lead after two days of the second Ashes cricket test, with the top order all getting starts Friday to help the hosts reach 378-6 at stumps.
Five dropped catches and some wayward bowling dented England and allowed the batters to capitalize.
Opener Jake Weatherald led from the start of Australia's innings with 72 from 78 balls, Marnus Labuschagne (65) completed back-to-back half centuries, and stand-in skipper Steve Smith made 61 as bat dominated ball despite some uneven bounce at the Gabba.
Alex Carey was dropped before he'd scored and again on 25, but survived to be unbeaten on 46 off 45 balls at stumps. Michael Neser also got a reprieve before finishing not out 15 in a 49-run seventh-wicket stand.
The series-opener in Perth was all over on Day 2, with Australia winning by eight wickets, but this day-night test in Brisbane seemingly still has a long way to go.
Joe Root’s unbeaten 138 — his first Ashes century for England in Australia — remains the standout innings.
The Australians were coasting at 291-3 in the night session until Brydon Carse took two wickets in four balls against the run of play. He ended a 95-run fourth-wicket partnership when Cameron Green (45) backed away too far from a half-volley and was bowled.
Carse then got a thick edge with a short ball to Carey from the next delivery but Ben Duckett grassed a regulation chance at gully.
Two balls later Smith pulled a short ball and Will Jacks reached out one-handed to pluck it out of the air at deep backward square. Australia suddenly was 292-5.
Carey and Josh Inglis, both wicketkeeper batters, added 37 for the sixth wicket to get Australia within range of England's first innings 334.
Duckett put down another catch, going with one hand at gully when Inglis edged Ben Stokes. But the England captain didn't rely on any help two balls later when he angled a cutter back into Inglis’ middle stump, bowling the Australian No. 7 for 23.
Stokes hit Neser on the pad first ball but it was given not out, and England wasted a review.
Carse then put down a catch off Jofra Archer’s bowling when Neser was on six, yet another reprieve for the Aussies.
It got worse for England when Root put down a catch to his right when Carey edged between wicketkeeper and slip.
The England pace bowlers had heavy loads and weren't able to stick to a consistent length, with Archer bowling 20 overs and returning 1-74, Stokes having figures of 2-93 in 17 overs and Carse going for 3-113.
England resumed Day 2 at 325-9 and added nine runs in 14 balls before No. 11 Archer was dismissed.
Root, the No. 1-ranked batter in test cricket, was 135 overnight and remained unbeaten when the 70-run last-wicket stand ended.
Travis Head, the star of Australia's series-opening win, added 30 more runs after a getting a reprieve when he was dropped on three by wicketkeeper Jamie Smith off Archer in the ninth over.
Head ran out of luck when he rushed through his shot to a ball from Carse and skied a catch to Gus Atkinson, ending a 77-run opening stand.
Weatherald made the scoring look easy as he raced to 50 from 45 balls, stroking nine boundaries and a six with a series of cut shots and uppercuts. He moved to 72 before he was hit on the foot by a full delivery from Archer that trapped him in front.
Weatherald walked back toward the pavilion without having a second look at the umpire and Australia was 146-2.
Smith's arrival at the crease was greeted with boos and jeers by the Barmy Army and the stand-in Australia captain had to duck under a 147 kph (91 mph) bouncer from Archer, the fastest delivery of the match.
The third-wicket pair put on 50 and seemed unperturbed until Stokes struck to slow the momentum.
Labuschagne was in good touch until he attempted a pull shot against a stock Stokes delivery and edged behind.
AP cricket: https://apnews.com/hub/cricket
England's captain Ben Stokes reacts after bowls a delivery during the second Ashes cricket test match between Australia and England in Brisbane, Friday, Dec. 5, 2025.. (AP Photo/Tertius Pickard)
Australia's Marnus Labuschagne celebrates his fifty runs during the second Ashes cricket test match between Australia and England in Brisbane, Friday, Dec. 5, 2025.. (AP Photo/Tertius Pickard)
Australia's Travis Head, left, talks to Australia's Jake Weatherald during the second Ashes cricket test match between Australia and England in Brisbane, Friday, Dec. 5, 2025.. (AP Photo/Tertius Pickard)
Australia's Travis Head plays a shot during the second Ashes cricket test match between Australia and England in Brisbane, Friday, Dec. 5, 2025.. (AP Photo/Tertius Pickard)
England's Joe Root plays a shot during the second Ashes cricket test match between Australia and England in Brisbane, Friday, Dec. 5, 2025.. (AP Photo/Tertius Pickard)
Australia's Marnus Labuschagne plays a shot during the second Ashes cricket test match between Australia and England in Brisbane, Friday, Dec. 5, 2025.. (AP Photo/Tertius Pickard)
Australia's Jake Weatherald plays a shot during the second Ashes cricket test match between Australia and England in Brisbane, Friday, Dec. 5, 2025.. (AP Photo/Tertius Pickard)
England's Jofra Archer plays a shot during the second Ashes cricket test match between Australia and England in Brisbane, Thursday, Dec. 4, 2025.. (AP Photo/Tertius Pickard)
England's Joe Root runs between the wickets as Australia's Mitchell Starc fields on the ground during the second Ashes cricket test match between Australia and England in Brisbane, Thursday, Dec. 4, 2025.. (AP Photo/Tertius Pickard)
England's Joe Root, centre, with team mates warms up before start the second day of the second Ashes cricket test match between Australia and England in Brisbane, Friday, Dec. 5, 2025.. (AP Photo/Tertius Pickard)
