BERLIN--(BUSINESS WIRE)--Nov 14, 2025--
ESMO AI & Digital Health 2025 - Massive Bio today introduced Reticulum Nexus, the company’s most significant technological leap to date: a patient-centric, multi-agent platform engineered to coordinate the full oncology journey, from first contact to last-mile enrollment, across networks operating at global scale.
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In an environment where clinical trial access has long been constrained by fragmented data pipelines, site-centric processes, and human-heavy workflows, Reticulum Nexus establishes a unified operating fabric. This next-generation system integrates clinical and operational intelligence to match, enroll, and collect outcomes to build more powerful advanced analytics.
The company’s most recent announcements include:
“Most systems optimize a single node,” said Selin Kurnaz, PhD, Cofounder & CEO. “Reticulum Nexus will help bring in the world’s first scalable patient journey, and paired with the enablement of AI agents.”
“ Moravec’s Paradox shows us the boundary between repetitive and contextual work,” said Arturo Loaiza-Bonilla, MD, Cofounder & Chief Medical AI Officer. “With Reticulum Nexus, multi-agent, contextual AI handles the operational load so clinicians can focus on human care. Dr. Arturo AI already supports thousands of patients; we can now safely scale to millions.”
“Radiant Core is the control plane that makes agentic AI dependable at production scale,” added Çağatay Çulcuoğlu, Cofounder, CTO & COO. “SYNERGYAI OS is the routing fabric connecting every workflow. Together, they deliver interoperability, auditability, and real-world performance from day one.”
Inside Reticulum Nexus
Radiant Core - the control plane focused on data quality, compliance, and agent behavior.
SYNERGYAI OS - the multi-agent operating system
Interoperable Architecture - native FHIR/mCODE integration, governance designed for regulated environments (GDPR, HIPAA).
Modules Available at Launch
About Massive Bio
Massive Bio, co-founded by Selin Kurnaz, Arturo Loaiza-Bonilla, and Çağatay Çulcuoğlu, transforms the pharmaceutical value chain with AI-driven solutions. As an AI-enabled real-world data company, Massive Bio streamlines patient journeys, improves access to cutting-edge treatments, and optimizes clinical trial operations across 17 countries. A founding member of the CancerX public-private partnership and participant in the White House Cancer Moonshot initiative, the company continues to lead the way in ethical AI and data-driven innovation.
For more information, visit www.massivebio.com.
Reticulum Nexus: Massive Bio’s new AI-driven multi-agent platform supporting every step of the patient journey.
NEW YORK (AP) — U.S. stocks are climbing with markets worldwide on Monday after oil prices and yields in the bond market gave back some of their jumps from last week.
The S&P 500 rose 0.6% and pulled back within 1.3% of its all-time high set last month. The Dow Jones Industrial Average was up 224 points, or 0.4%, as of 9:35 a.m. Eastern time, and the Nasdaq composite was 0.8% higher.
They got some help from the price for a barrel of Brent oil falling 3.1% to $100.62. While that’s still much higher than its roughly $72 price from earlier this summer, it’s down from the nearly $110 it touched last week.
Oil prices are swinging up and down as some crude from the Middle East is able to sail through the Strait of Hormuz, though nowhere close to as much as the industry and customers would like because of the war with Iran. Morgan Stanley’s Michael Wilson said another swing higher in prices for oil, gasoline and other refined products is the main risk he sees in the near term that could keep the U.S. stock market from rising to his forecast for the year’s end.
The average price for a gallon of regular gasoline across the United States has already climbed to nearly $4.48, according to AAA. That's up from less than $4.32 just a week earlier and from $3.18 a year ago.
Monday’s pullback in oil prices helped lower the pressure coming from the bond market. The yield on the 10-year Treasury eased to 4.96% from 5.01% late Friday after it crossed above the 5% threshold last week for the first time in three years.
Higher yields slow the economy by making it more expensive to borrow money, hurting not just the U.S. government that has to borrow to pay its bills but also U.S. households and businesses.
Worries of course remain about how much oil is available for customers worldwide, ING commodities strategists Ewa Manthey and Warren Patterson wrote in a commentary on Monday. However, they said profit-taking by investors after the recent jump in oil prices, together with hopes for constructive discussions at this week’s U.N. General Assembly and at a meeting between China’s and the United States’ leaders, helped improve market sentiment.
Treasury Secretary Scott Bessent told reporters following talks Sunday with Chinese Vice Premier He Lifeng in New York that the U.S. had “a very successful engagement” with the Chinese side. Bessent said talks with China touched on trade and AI. China and the United States have been discussing reciprocal tariff reductions on $30 billion worth of goods from each side.
In Beijing, China’s Foreign Ministry on Monday confirmed that Xi Jinping will pay a state visit to the U.S. between Sept. 23 and 25. Experts and policymakers believe trade, tariffs, AI safety, among other items, are likely to be on the agenda. The war in Iran and developments in the Middle East and ties between China and Iran could also be discussed.
On Wall Street, stocks in the artificial-intelligence industry continue to stabilize following their worldwide slide at the start of last week. Leaders of the AI industry have recently warned a slowdown is needed in the industry’s development for the safety of humanity.
Advanced Micro Devices climbed 4.8%, while Nvidia added 0.4%.
Stocks enmeshed in the cryptocurrency industry, meanwhile, rallied after bitcoin's price rose back above $85,000 and returned to where it was in January. Coinbase Global jumped 5.4%, and Robinhood Markets rose 2.8%.
Stock indexes around the world also climbed thanks to the easing of oil prices and bond yields. Indexes gained 1% in France, 1.2% in Hong Kong and 1.6% in South Korea.
AP Business Writers Chan Ho-him and Michelle Chapman contributed to this report.
Traders work on the floor at the New York Stock Exchange in New York, Wednesday, Sept. 16, 2026. (AP Photo/Seth Wenig)
Currency traders work near a screen showing the Korea Composite Stock Price Index (KOSPI) in the foreign exchange dealing room at the Hana Bank headquarters in Seoul, South Korea, Monday, Sept. 21, 2026. (AP Photo/Ahn Young-joon)
Currency traders work in the foreign exchange dealing room at the Hana Bank headquarters in Seoul, South Korea, Monday, Sept. 21, 2026. (AP Photo/Ahn Young-joon)
A screen shows the Korea Composite Stock Price Index (KOSPI) in the foreign exchange dealing room at the Hana Bank headquarters in Seoul, South Korea, Monday, Sept. 21, 2026. (AP Photo/Ahn Young-joon)
