Align Technology Announces Invisalign® System With Mandibular Advancement Featuring Occlusal Blocks for Class II Skeletal and Dental Correction

MANILA, Philippines--(BUSINESS WIRE)--Nov 24, 2025--

Align Technology, Inc. (Nasdaq: ALGN), a leading global medical device company that designs, manufactures, and sells the Invisalign® System of clear aligners, iTero™ intraoral scanners, and exocad™ CAD/CAM software for digital orthodontics and restorative dentistry, today announced commercial availability in the Philippines of the Invisalign System with mandibular advancement featuring occlusal blocks designed specifically to address Class II skeletal and dental correction by simultaneously advancing the mandible while aligning the teeth. This innovative solution is Align’s first clear aligner product with integrated solid occlusal blocks that is designed to deliver predictable mandibular advancement. Invisalign occlusal blocks provide durability, improve engagement, and enable vertical opening to offer earlier advancement of the mandible in cases like skeletal Class II with deep bite to improve treatment efficiency.

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The Invisalign System with mandibular advancement featuring occlusal blocks is the latest clinical innovation that expands Align’s Class II treatment portfolio for growing patients by offering practitioners a comprehensive solution for treating growing patients with Class II malocclusions caused by mandibular retrusion. Class II malocclusion is one of the most common orthodontic problems, characterized by a discrepancy in jaw alignment where the lower jaw (mandible) is positioned too far back relative to the upper jaw (maxilla) and represents approximately 30-45% of malocclusions globally. This condition can lead to functional, aesthetic, and other challenges for patients if left untreated.

The Invisalign System with mandibular advancement featuring occlusal blocks is primarily intended for growing patients in the late mixed or early permanent dentition stages (ages 10-16), who are still experiencing growth. By leveraging the natural growth potential during pre-adolescence and adolescence, the Invisalign System with mandibular advancement featuring occlusal blocks facilitates effective correction of Class II malocclusions, helping to improve occlusal relationships, enhance facial aesthetics, and provide long-term functional benefits, including:

“The Invisalign System with mandibular advancement featuring occlusal blocks reflects Align’s continued commitment to expanding the capabilities of the Invisalign System, enabling doctors to treat a wider range of malocclusions with precision and efficiency, and helps to continue to advance clear aligners as the standard of care in digital orthodontics,” said Sreelakshmi Kolli, Align Technology EVP, chief product and digital officer. “This latest innovation demonstrates our significant investment in delivering digital orthodontic solutions to growing patients that empower doctors to achieve predictable outcomes while enhancing the patient experience.”

“The Invisalign System with mandibular advancement featuring occlusal blocks represents a breakthrough in Class II treatment with clear aligners by allowing doctors to simultaneously address dental and skeletal discrepancies in a more predictable and efficient manner,” said Dr. Mitra Derakhshan, Align Technology EVP and chief clinical officer. “The integration of occlusal blocks enhances mandibular engagement as well as provides bite opening making this a versatile solution for different Class II malocclusion including deep bite or div 2. The Invisalign System with mandibular advancement featuring occlusal blocks, gives doctors and patients a better option for Class II correction in growing patients while simultaneously straightening their teeth, including more options for feature placement, such as attachments on teeth underneath the blocks (3).”

“Treatment outcomes with the Invisalign System with mandibular advancement featuring occlusal blocks are on par with traditional Clark Twin Blocks,” said Dr. Ronald Sluiter, an orthodontist practicing in New Zealand who has treated 50 patients to date. “In addition, the enhanced comfort of the Invisalign occlusal blocks increases predictability-- because comfort leads to patient compliance–and compliance leads to better outcomes.”

“Class II correction in growing patients is smooth sailing with the Invisalign System with mandibular advancement featuring occlusal blocks,” said Dr. Steve Semaan, an orthodontist practicing in Australia. “The patients instinctively know how to bite, and it works so I don’t see any crushed blocks. The fact that we see no crushing issues means patients can keep moving through treatment without any delays or additional appointments.”

“I’m very happy with the new Invisalign System with mandibular advancement featuring occlusal blocks design,” said Dr. Belinda Weltman, Vancouver, Canada. “Patients can bite down easily without risk of damaging or distorting the blocks, and the mandibular advanced position is easy to maintain. My young patients have found it very easy to transition to this appliance with minimal discomfort, and compliance has been a breeze."

“The Invisalign System with mandibular advancement featuring occlusal blocks provides the ideal block engagement that helps hold the mandible in the proper position for patients that also have mandibular asymmetry. This allows for more efficient corrections when desired,” said Dr. Francis Janisse, Windsor, Canada. “Invisalign system with mandibular advancement featuring occlusal blocks removes the need for auxiliary elastics, which removes one more obstacle for patients. In addition, the trays do not require palatal coverage like traditional removable Class ll correctors, and there are no changes in the insertion and removal process of the aligners. My younger patients love the ability to remove the aligners for eating, which is not commonly an option for patients that require fixed Class ll correctors or elastics.”

The Invisalign System with mandibular advancement featuring occlusal blocks is now commercially available to Invisalign-trained doctors in Australia, New Zealand, Japan, Hong Kong, Malaysia, Singapore, India, Korea, China, Thailand and Vietnam. Along with the Invisalign® Palatal Expander System, Invisalign First™ and Invisalign System with mandibular advancement featuring occlusal blocks, this latest innovation supports the commitment to establishing a unique and differentiated portfolio that supports growing patients throughout their continuum of care.

For more information about the Invisalign System with mandibular advancement featuring occlusal blocks, or to schedule a training session, please visit www.invisalign.com.ph or contact your local Align Technology representative.

1. Compared to Invisalign aligners previously made from single-layer (EX30) material.
2. Studies show that patient discomfort with functional appliances affect patient compliance with the prescribed wear time and could lead to unsatisfactory outcomes. https://pubmed.ncbi.nlm.nih.gov/34949565/
3. In some cases, attachments may be removed on teeth under occlusal blocks due to interferences with other features.

About Align Technology, Inc.

Align Technology designs and manufactures the Invisalign® System, the most advanced clear aligner system in the world, iTero™ intraoral scanners and services, and exocad™ CAD/CAM software. These technology building blocks enable enhanced digital orthodontic and restorative workflows to improve patient outcomes and practice efficiencies for over 291.0 thousand doctor customers and are key to accessing Align’s 600 million consumer market opportunity worldwide. Over the past 28 years, Align has helped doctors treat approximately 21.4 million patients with the Invisalign System and is driving the evolution in digital dentistry through the Align™ Digital Platform, our integrated suite of unique, proprietary technologies and services delivered as a seamless, end-to-end solution for patients and consumers, orthodontists and GP dentists, and lab/partners. Visit www.aligntech.com for more information.

For additional information about the Invisalign System or to find an Invisalign doctor in your area, please visit www.invisalign.com.ph. For additional information about the iTero digital scanning system, please visit www.itero.com/en-APAC. For additional information about exocad dental CAD/CAM offerings and a list of exocad reseller partners, please visit www.exocad.com.

Invisalign, iTero, exocad, Align, Align Digital Platform, and iTero Lumina are trademarks of Align Technology, Inc.

The Invisalign® System with mandibular advancement featuring occlusal blocks is the latest clinical innovation that expands Align’s Class II treatment portfolio for growing patients by offering practitioners a comprehensive solution for treating growing patients with Class II malocclusions caused by mandibular retrusion.

NEW YORK (AP) — Stocks are rushing higher worldwide, and oil prices are easing Wednesday as hopes build that the war with Iran could end soon. That's even though some of the signals investors saw as hopeful are already under dispute, and several prior bouts of optimism in financial markets quickly got undercut by continued, fierce fighting in the war.

The S&P 500 rallied 0.9% and added to its leap from the day before, which was its best since last spring. That followed even bigger gains for stock markets across Europe and Asia, including an 8.4% surge in South Korea, which were catching up to Wall Street’s rally from Tuesday.

The Dow Jones Industrial Average was up 294 points, or 0.6%, as of 2:08 p.m. Eastern time, and the Nasdaq composite was 1.3% higher.

Oil prices also fell back toward $100 per barrel after President Donald Trump said late Tuesday that the U.S. military could end its offensive in two to three weeks.

That added to optimism following a couple tenuous signals of hope from earlier Tuesday that Wall Street latched onto, including a news report quoting Iran’s president as saying that it has “the necessary will to end the war” as long as certain requirements are met, including “guarantees to prevent a recurrence of aggression.”

The worry on Wall Street has been that the war may last a long time and keep oil and natural gas from the Persian Gulf out of global markets, which could create a brutal blast of inflation.

But hope has been quick to reverse to doubt on Wall Street, triggering manic swings back and forth for financial markets since the war with Iran began. Trump has also made statements that lifted markets, only to see the gains quickly disappear after increasing his military threats.

Shortly before Wall Street began trading on Wednesday, Trump claimed in a post on his social media network that Iran “has just asked the United States of America for a CEASEFIRE!”

“We will consider when Hormuz Strait is open, free, and clear. Until then, we are blasting Iran into oblivion or, as they say, back to the Stone Ages!!!”

But Iran’s Foreign Ministry spokesman, Esmail Baghaei, quickly called that claim “false and baseless,” according to a report on Iranian state television.

Oil prices also remain high, even if they’ve eased recently. The price for a barrel of Brent crude oil, the international standard, was sitting at $101.51 following its declines, which is still up from roughly $70 before the war began.

U.S. gasoline prices rose again overnight to a national average of $4.06 per gallon, according to the auto club AAA.

Iran, meanwhile, hit an oil tanker off the coast of Qatar and Kuwait’s airport on Wednesday while airstrikes battered Tehran as the fighting continued. Iran also continues to hold a grip on the Strait of Hormuz, where a fifth of the world’s traded oil passes during peacetime.

“De-escalation hopes have given markets a lift, but we think the effects of the war would, in many cases, persist even if the war did end soon,” Thomas Mathews, head of markets, Asia Pacific at Capital Economics, said in a research note Wednesday.

“It’s worth thinking through how markets might fare if the war were to end ‘very soon,’” he wrote. “Do markets have further to recover if sentiment continues to improve? The answer is almost certainly yes.”

The White House said Trump will deliver a public address Wednesday evening on the Iran war.

On Wall Street, most stocks rose as Big Tech powered the move higher. Gains of 3.8% for Alphabet and 0.8% for Nvidia were two of the strongest forces lifting the S&P 500.

Eli Lilly climbed 5.1% after U.S. regulators approved its GLP-1 pill for weight loss.

Such gains have pulled the S&P 500, which sits at the heart of many 401(k) accounts, back to within 5.6% of its all-time high set early this year. Just on Monday, the index briefly neared a 10% drop from its record, a steep-enough fall that professional investors have a name for it: a “correction.”

Nike sank 14.5% even though it reported a stronger profit for the latest quarter than expected. Analysts said it gave some lackluster financial forecasts.

Hasbro fell 4.8% after the toy company found someone had gained unauthorized access to its computer network and is working to assess the full impact.

Energy companies fell broadly as oil prices eased. Exxon Mobil slumped 5% and Chevron fell 4.9%.

In stock markets abroad, indexes leaped more than 2% in France and Germany. Asian markets had even bigger gains.

Tokyo’s Nikkei 225 jumped 5.2% after a survey showed business sentiment for major Japanese manufacturers improved despite worries about the Iran war.

In the bond market, Treasury yields held relatively steady after a report said U.S. retailers made more money in February than economists expected. A separate report said U.S. manufacturing growth last month was slightly faster than economists expected.

The 10-year Treasury yield rose to 4.32% from 4.30% late Tuesday.

AP Business Writers Chan Ho-him and Matt Ott contributed.

James Conti works on the floor at the New York Stock Exchange in New York, Tuesday, March 31, 2026. (AP Photo/Seth Wenig)

Philip Finale works on the floor at the New York Stock Exchange in New York, Tuesday, March 31, 2026. (AP Photo/Seth Wenig)

Currency traders watch monitors near a screen showing the Korea Composite Stock Price Index (KOSPI), left, at the foreign exchange dealing room of the Hana Bank headquarters in Seoul, South Korea, Wednesday, April 1, 2026. (AP Photo/Ahn Young-joon)

Currency traders watch monitors near a screen showing the Korea Composite Stock Price Index (KOSPI), top center, and the foreign exchange rate between U.S. dollar and South Korean won, top center left, at the foreign exchange dealing room of the Hana Bank headquarters in Seoul, South Korea, Wednesday, April 1, 2026. (AP Photo/Ahn Young-joon)

Currency traders work at the foreign exchange dealing room of the Hana Bank headquarters in Seoul, South Korea, Wednesday, April 1, 2026. (AP Photo/Ahn Young-joon)

A currency trader reacts near a screen showing the Korea Composite Stock Price Index (KOSPI), right, and the foreign exchange rate between U.S. dollar and South Korean won at the foreign exchange dealing room of the Hana Bank headquarters in Seoul, South Korea, Wednesday, April 1, 2026. (AP Photo/Ahn Young-joon)

A screen displays financial information on the floor at the New York Stock Exchange in New York, Tuesday, March 31, 2026. (AP Photo/Seth Wenig)