China launches world's first foundation model for genomic analysis

An artificial intelligence (AI) foundation model specialized for analyzing human genetic diversity was launched at Shanghai's cutting-edge Model Speed Space innovation hub on Tuesday.

Named SNPBAG, it is the world's first large model built specifically for genomic analysis, promising to precisely predict diseases and advance personalized health care.

The model focuses on single nucleotide polymorphisms (SNPs), the most common type of genetic variation among people, which influence traits such as height, intelligence and personality.

Currently, SNPBAG can be used for ancestry tracing and kinship identification. In the future, with further training, it is expected to predict disease risks at various life stages based on DNA sequences, offering higher screening accuracy than existing genetic testing methods.

"As far as we know, traditional methods examine SNPs point by point for correlations with traits like height or intelligence, without taking into account, for example, interactions between or among genes. Therefore, we need a model that can autonomously identify these complex relationships. Now, we've found such a tool that can bring close two gene expressions [of the human body] that are far away from each other and provide biological interpretations," said Tang Kun, an expert of computational biology and founder of Shanghai Feipu Intelligent Technology Co., Ltd.

Looking ahead, the model will support the development of China's sovereign genomic database, promote its domestic self-reliance, enhance AI-driven drug discovery and improve the target screening success rates by over 200 percent. It also aims to make precision health care more accessible.

"The most well-known application is non-invasive prenatal screening. Currently, only a few conditions are covered by national insurance, but there are over 20,000 rare diseases in children. We are now collaborating with Shanghai Children’s Hospital to expand screening coverage," said Lu Sitong, CEO of Shanghai Feipu Intelligent Technology.

With SNPBAG, non-invasive prenatal screening is expected to detect a broader range of rare diseases in the future. The company said it also plans to launch consumer-facing products to benefit the general public.

China launches world's first foundation model for genomic analysis

China's blue-chip CSI 300 Index made modest gains in the past week thanks to the huge electrification campaign that reduces the country's exposure to the volatile oil price as the continuing conflict in the Middle East enters the second week, said an analyst on Friday.

Chinese stocks closed lower on Friday, with the benchmark Shanghai Composite Index down 0.81 percent to 4,095.45 points.

Timothy Pope, a market analyst for China Global Television Network, said the CSI 300 Index made modest gains despite a rough week for both Chinese and global stock markets.

"The conflict in the Middle East really shows no sign of winding down and it has been as you said another rough week for the global markets. Today the Shanghai Composite Index closed down 0.8 percent, and ended lower for the week as well, but the blue-chip CSI 300 Index actually managed to make some modest gains this week. And that fits what we've been hearing from analysts and investment banks, including Morgan Stanley and UBS. They've said that China's got less oil exposure than other economies. This is partly because of the huge electrification campaign which has been happening in China from family cars to road haulage, and also just the total energy mix here. But we know that oil isn't the only thing that's not getting out of the Middle East at the moment. Fertilizer has emerged as another big disruption point and we have seen in the last 48 hours China already begin early releases of fertilizer reserves ahead of the spring planting season. With all that in the mix we have seen the likes of Morgan Stanley and UBS touting A-shares as a diversification option and a resilient market in this risk-off investment environment," said Pope.

"Sector-wise today we saw some consumer stocks rising -- led by liquor makers, in particular, Kweichow Moutai. There were also some limited gains for Chinese real estate and financial firms. But with the oil price still extremely volatile, Chinese resources and energy shares pulled back today to become the two worst-performing sectors," said Pope.

Chinese blue-chip stocks make gains amid a rough week for global markets: analyst