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Baszucki Group贊助牛津大學利用生酮療法治療早期精神病的臨床試驗

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Baszucki Group贊助牛津大學利用生酮療法治療早期精神病的臨床試驗
Business

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Baszucki Group贊助牛津大學利用生酮療法治療早期精神病的臨床試驗

2026-05-22 23:23 Last Updated At:23:41

加州,聖馬提歐--(BUSINESS WIRE)--五月 22, 2026--

(美國商業資訊)-- Baszucki Group今天宣布撥款117萬英鎊贊助牛津大學進行隨機對照試驗,評估將生酮飲食療法用於處於精神病臨床高風險期 (CHR-P) 患者的可行性、安全性和有效性。研究人員將測試這種營養療法改善患者身心健康的能力。這項計畫以數量日增的相關研究為基礎,這些研究表明代謝療法具有治療嚴重精神疾病的潛力。

本新聞稿包含多媒體資訊。完整新聞稿請見此: https://www.businesswire.com/news/home/20260521515101/zh-HK/

精神病性障礙加諸個人沉重的 負擔 ,而且可縮短預期壽命。精神病並不是突發性的,通常是在經歷了一段早期症狀輕微期之後才會顯現出來。處於這個階段的患者被歸類為精神病臨床高風險期 (CHR-P) 患者。這一關鍵的發病前階段為 預防性治療提供了一個窗口期 。然而,儘管鑑定CHR-P的診斷工具已相當成熟, 現有的治療方案仍十分有限 。目前還沒有針對性的特定治療方法可以降低CHR-P患者發展為完全性精神病的機率。這一現狀突顯出開發新型介入手法的迫切需求。

這項隨機對照試驗 (RCT) 將50名年齡介於14至35歲之間的CHR-P患者隨機分配到改良生酮飲食組和對照飲食組,進行為期12週的試驗。在整個試驗期間,研究人員將利用「高風險精神狀態綜合評估量表」(CAARMS) 持續監測患者的症狀嚴重程度。這個量表是專為評估處於精神病發病高風險期的年輕人之症狀嚴重程度而設計的。參與者將獲得持照營養師的專業指導,並使用血糖/酮體監測儀追蹤是否確實遵循生酮飲食方案。為了評估治療的有效性和耐受性,研究團隊將全面評估患者的症狀嚴重程度、認知功能、睡眠行為及身體健康狀況。此外,本試驗還將透過電子健康檔案系統,在介入結束後對患者進行長達三年的健康狀況追蹤,以評估該療法的長期影響。

「我們認為,生酮療法有望成為一種非污名化且易於取得的介入手段,造福那些正經歷精神病早期徵兆的人。如發現確有療效,這種飲食療法將成為一種全新工具,讓我們趕在精神病發作之前及早介入。」研究主持人、醫學博士、哲學博士、專科醫師 (CCT)、牛津大學副教授、榮譽精神科顧問醫師及Wellcome信託早期職業學者 Amedeo Minichino 說,「我們希望透過研究通常先於精神病發作的關鍵窗口期,能夠改變患者心理健康的長期發展軌跡。」

由於大多數CHR-P患者都不曾接受過抗精神病藥物治療,本研究將有特殊機會,既評估把生酮療法當作獨立治療手段的臨床療效,也探究這種疾病以及這項介入背後的生物學機制。越來越多的新證據表明,腦能量代謝受損(包括 粒線體功能障礙 )或有助於識別有高傾向日後發展為精神病的CHR-P患者。在部分患者亞群中,本試驗將利用血液生物標記及神經影像技術直接測定腦能量。

「這項研究將進一步了解用生酮療法改善這群高度脆弱患者身心健康的潛力。」Baszucki Group共同創辦人暨總裁Jan Ellison Baszucki說,「這個企圖宏大的計畫提供了一個難得的機會,讓我們深入探究生酮療法是否能夠為未曾接受過藥物治療的患者徹底改變嚴重精神疾病的發展軌跡。我們非常榮幸能夠支援牛津大學的研究團隊進行這項開創性的試驗。」

如欲進一步了解Baszucki Group目前資助的研究計畫,請造訪: Metabolic Mind網站 。

關於Baszucki Group

Baszucki Group 由Roblox創辦人兼執行長David Baszucki和暢銷書作家Jan Ellison Baszucki創立於2021年。該集團利用私人捐贈、影響力投資、宣傳宣導、故事講述和社群建構等方式在科學、醫學、農業、食品及生態環境系統領域推動根本性變革。Baszucki Group的主要目標是透過支持代謝、精神病學和神經科學交叉領域的研究活動來改善心理健康。如欲進一步瞭解精神障礙以及腦部健康的代謝治療方法,包括生酮療法,請造訪Baszucki Group的非營利性計畫 Metabolic Mind 。

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SOURCE: Baszucki Group

Copyright Business Wire 2026.

PUB: 05/22/2026 11:23 AM/DISC: 05/22/2026 11:23 AM

http://www.businesswire.com/news/home/20260521515101/zh

Baszucki Group撥款117萬英鎊贊助牛津大學利用生酮療法治療早期精神病的試驗。

Baszucki Group撥款117萬英鎊贊助牛津大學利用生酮療法治療早期精神病的試驗。

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