NEW YORK--(BUSINESS WIRE)--Jun 17, 2026--
Clear Health, a telehealth platform for personalized, at-home skincare, launches Isoclear™, the first prescription topical acne treatment built around isotretinoin - the same active ingredient used in oral Accutane - delivered through a multi-phase regimen.
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Isoclear takes one of dermatology’s most well-known molecules and reimagines it in a topical format, combining clinically proven ingredients into customized, prescription formulations delivered through a digital-first experience.
Michael Chang, Clear Health CEO & Co-Founder, says, “Oral isotretinoin is highly effective, but it’s not the right fit for every patient. Isoclear expands access to this gold-standard molecule in a way that’s more flexible, personalized, and aligned with how patients want to receive care today.”
“Isotretinoin has long been one of the most effective therapies we have for treating acne,” said Dr. Aaron Farberg, MD, board-certified dermatologist. “What’s new here is the ability to deliver it topically in a personalized formulation, giving patients a targeted approach that can improve tolerability while maintaining clinical impact.”
How it works: Clear Health patients are connected with licensed dermatologists who prescribe personalized formulations and oversee care through a streamlined digital experience. All treatments are prescription-only and fulfilled by licensed pharmacies based on an individual provider’s plan, with formulations adjusted over time as the patient’s skin improves. Many patients see results within several weeks.
Isoclear is available for $50 per month, billed as $100 for a two-month supply. Patients can also choose an annual plan for $40 per month, billed at $480 annually. Three-month supply and billing options are available during the Fade and Renew phases of treatment.
Phase 1 – CLEAR (Active Acne Treatment)
Targets breakouts at the source by reducing clogged pores, bacteria, and inflammation
Phase 2 – FADE (Post-Acne Repair)
Focuses on improving discoloration and restoring even skin tone following breakouts
Phase 3 – RENEW (Maintenance & Skin Quality)
Supports long-term skin health, texture, and overall appearance
Unlike oral isotretinoin, which requires enrollment in the iPLEDGE risk management program and ongoing laboratory monitoring, Isoclear is delivered topically, enabling a more flexible, dermatologist-guided treatment approach without the same administrative burden associated with oral therapies. This is an important shift for patients, particularly women, who may have historically been hesitant to pursue oral isotretinoin despite its effectiveness. Additionally, clinical research supports topical isotretinoin tolerability and efficacy in comparison to topical retinoids currently on the market (see footnoted clinical studies below).
Jason Lang, PharmD and Clear Health Advisor, says, “Every formulation is prepared by licensed U.S. compounding pharmacies following applicable USP standards, and all active pharmaceutical ingredients are sourced from FDA-registered and inspected facilities. This ensures patients receive treatments that meet rigorous quality and safety standards.”
Important Safety Information
This product is a compounded formulation prepared by a licensed pharmacy pursuant to Section 503A of the Federal Food, Drug, and Cosmetic Act. Compounded medications are not FDA-approved, meaning they have not been evaluated by the FDA for safety, effectiveness, or quality. Licensed medical providers may prescribe compounded preparations at their professional discretion based on an individual patient’s needs. This product is intended for use only under medical supervision.
The Clear Health Guarantee
If, after at least four (4) months of prescribed and directed use of Isoclear™, your provider determines that you have not achieved an adequate clinical response and that oral isotretinoin (Accutane®) or another treatment option is medically appropriate, Clear Health will provide your first treatment consultation and first month of medication at no additional cost through the Clear Health network. Offer subject to provider evaluation, medical eligibility, and applicable prescribing requirements. Not available to patients who have previously enrolled in Clear Health's Accutane program. Limit one guaranteed redemption per patient.
Clinical Study References
About Clear Health
Clear Health is a telehealth platform redefining how patients access prescription skincare. Founded in 2022 and headquartered in Connecticut, the company connects patients with licensed providers to deliver personalized treatment plans at home. With a focus on isotretinoin, Clear Health has developed a microdosing protocol designed to make treatment more accessible and manageable for a broader range of patients.
Clear Health Launches Isoclear™, the First Prescription Topical Isotretinoin System for Acne Treatment in the U.S.
Florida carried out a record-tying 19th execution of the year in an unusual instance of three states administering the death penalty on the same day.
Jesse Guardado was pronounced dead at 6:13 p.m. following a three-drug injection at a state prison in Starke. He had pleaded guilty to fatally stabbing 75-year-old Jackie Malone inside her Walton County home in 2004 before stealing her jewelry box, $80 and other valuables to buy drugs. The woman had helped him get a job and housing.
Hours earlier, Indiana executed a man for killing two children in a house fire in 2010, and in Alabama, a man received the last lethal injection of the day for his conviction in the killing of an elderly man and woman in a home robbery.
The executions were taking place the same day California Gov. Gavin Newsom announced he will commute all 548 death sentences in his state, saying that he believes “state-sanctioned killing is incompatible with California’s values."
The announcement was a sharp contrast to Florida, where outgoing Republican Gov. Ron DeSantis has made aggressive use of the death penalty like few other governors. His state has carried out more than half of the 34 executions so far this year in the U.S., where capital punishment has come under renewed scrutiny following Tennessee's failed execution of Christa Pike in September.
It is the second time since August that three states had organized executions on a single day, although it remains unusual. Prior to this year, the last time it happened was 2010.
Guardado, 64, was already strapped to a gurney with an IV in his arm when the curtain to the Florida death chamber went up promptly at 6:00 p.m. Asked if he had any last statement, he replied, “I would like to once again apologize for the pain and suffering I’ve caused to the victim’s family and my own family as well.”
The drugs began flowing immediately after that. About a minute later, Guardado began breathing heavily, followed by some sputtering and twitching for another minute. As the twitching subsided, the execution team warden shook Guardado and shouted his name, but got no response. A medic checked for a pulse soon after and pronounced Guardado dead.
A federal appeals court said in 2024 that Guardado received a “full and fair” hearing during the death penalty phase of his case. The U.S. Supreme Court denied his last appeal without comment earlier Thursday.
DeSantis, who leaves office in January, has said he wants to bring justice to victims' families who have often waited decades for death sentences to be carried out. He signed the death warrants that led to a state record of 19 executions in 2025. The state will set a new record if two more executions are carried out as planned later this year.
The victim’s son, Patrick Malone, spoke briefly to media witnesses after the execution. Instead of discussing his mother or her murder, he questioned those who oppose the death penalty.
“Do such people ever think about what happened to the victim or consider the unending aftermath the victim’s family endures and relives every time that terrible event comes up?” Malone said.
In neighboring Alabama, Michael Taylor, 54, received a lethal injection later Thursday and was pronounced dead at 6:10 p.m. local time.
The state changed the execution method after a judge declared a nitrogen gas method unconstitutional.
Taylor's attorneys had objected to the last-minute switch to lethal injection since he selected nitrogen gas as his method years ago, but a judge ruled against Taylor.
In 1991, Taylor, then 19, fatally beat two people, ages 83 and 79, with a metal bar during a robbery in their Gadsden, Alabama, home. Police arrested him with the victims’ Cadillac an hour away in Birmingham.
Death penalty opponents had unsuccessfully urged Republican Gov. Kay Ivey to reduce Taylor’s sentence to life in prison, noting his age and immaturity at the time. She declined.
In Indiana, Jeffrey Weisheit, 50, was pronounced dead at 12:45 a.m. at the state prison in Michigan City, said Noelle Russell, spokesperson at the Department of Correction. He had no final words.
Weisheit had publicly acknowledged killing his girlfriend’s two children in a house fire in the Evansville area in 2010 but had hoped Gov. Mike Braun would grant clemency and change his sentence to life in prison. Braun declined.
Lawyers failed to persuade Braun, a Republican, to allow Weisheit to undergo brain scans in an effort to reinforce their argument that he has a history of head injuries and mental health problems that should prevent execution.
Weisheit's last objection centered on the state's planned use of lethal drugs purchased from a pharmacy that is facing a disciplinary hearing next week at the Indiana Pharmacy Board. The Indiana Supreme Court declined to intervene Wednesday night, though two of the five justices wanted a 10-day stay for more information about the drugs' expiration and storage.
The execution provided “long-awaited justice for Alyssa Lynch and her brother Caleb, two innocent children whose lives were stolen in an act of unspeakable cruelty," Indiana Attorney General Todd Rokita said.
Americans have long been divided over the death penalty, with nearly half of states banning capital punishment outright and just a handful of others carrying out most of the nation’s executions each year.
This story has been updated to correct that Christa Pike's failed execution was in September, not October.
Fischer reported from Starke, Florida, and Chandler from Montgomery, Alabama. Associated Press reporter Ed White contributed from Detroit.
FILE - Law enforcement vehicles sit parked outside the Florida state prison in Starke, Fla., on July 28, 2026. (AP Photo/David Fischer, File)
The entrance to W.C. Holman Correctional Facility in Atmore, Ala., is shown on Oct. 17, 2024. (AP Photo/Kim Chandler) Photo taken with a smartphone.
This photo provided by the Indiana Department of Correction shows Jeffrey Weisheit. The Indiana Parole Board is recommending that the death penalty remain in place for Weisheit who killed two children in a house fire.(Indiana Department of Correction via AP)
This undated photo provided by the Alabama Department of Corrections on Thursday, Nov. 5, 2026, shows Michael Taylor. (Alabama Department of Corrections via AP)
