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REYKJAVIK, Iceland, May 21, 2025 /PRNewswire/ -- In a study published in Nature today "Sequence diversity lost in early pregnancy," scientists from deCODE genetics, a subsidiary of Amgen, estimate that around one in 136 pregnancies are lost due to new mutations in the fetus. In other words, millions of pregnancies worldwide are lost because of mutations every year.
The human genome varies between individuals, but there are some locations in the genome where there seems to be little or no sequence variation between individuals. This raises the question whether the sequences at these locations are essential for human development? It is known that mutations in essential genomic sequences are major contributors to neurodevelopmental disorders, the question remains, do they also contribute to pregnancy loss?
As part of a Nordic collaboration, scientists from deCODE genetics sought to answer these questions by sequencing 467 samples from pregnancy losses from a prospective study initiated by Henriette Svarre Nielsen and Eva R. Hoffmann.
Interestingly, by comparing the genomes of the fetuses from pregnancy losses to their parents the scientists found that the fetuses harbored a similar number of new mutations as adults.
"Despite the similar numbers, we discovered that the main difference between the lost fetuses and adults was that the mutations in the fetuses occurred in essential genomic sequences," says Hákon Jónsson scientist at deCODE genetics, and one of the authors on the paper.
Moreover, they managed to pinpoint when, in the development of the fetus, some of the mutations occurred.
In addition to mapping new mutations in the lost fetuses, they also showed that some couples are at a higher risk of pregnancy loss due to genetic compatibility issues. You inherit one copy of a gene from each parent, and most of the time, you are fine with one defective copy, but problems can arise if you inherit a defective copy from both parents.
"We have shown previously that for certain genes, you never observe two defective copies in adult genomes, but we found two defective copies in some of the pregnancy losses. Importantly, these involve a high risk for recurrence of pregnancy loss for the couple but can be selected against in IVF treatments," says Guðný A. Árnadóttir scientist at deCODE genetics, and one of the authors on the paper.
Along with recombination, the continuous generation of mutations enables us to evolve as a species. However, this continuous influx of new mutations comes at the expense of rare diseases. This study demonstrates the contribution of mutations to pregnancy loss and sheds new light on conserved sequences in the human genome.
Based in Reykjavik, Iceland, deCODE genetics is a global leader in analyzing and understanding the human genome. Using its unique expertise and population resources, deCODE has discovered genetic risk factors for dozens of common diseases. The purpose of understanding the genetics of disease is to use that information to create new means of diagnosing, treating and preventing disease. deCODE genetics is a wholly-owned subsidiary of Amgen.
REYKJAVIK, Iceland, May 21, 2025 /PRNewswire/ -- In a study published in Nature today "Sequence diversity lost in early pregnancy," scientists from deCODE genetics, a subsidiary of Amgen, estimate that around one in 136 pregnancies are lost due to new mutations in the fetus. In other words, millions of pregnancies worldwide are lost because of mutations every year.
The human genome varies between individuals, but there are some locations in the genome where there seems to be little or no sequence variation between individuals. This raises the question whether the sequences at these locations are essential for human development? It is known that mutations in essential genomic sequences are major contributors to neurodevelopmental disorders, the question remains, do they also contribute to pregnancy loss?
As part of a Nordic collaboration, scientists from deCODE genetics sought to answer these questions by sequencing 467 samples from pregnancy losses from a prospective study initiated by Henriette Svarre Nielsen and Eva R. Hoffmann.
Interestingly, by comparing the genomes of the fetuses from pregnancy losses to their parents the scientists found that the fetuses harbored a similar number of new mutations as adults.
"Despite the similar numbers, we discovered that the main difference between the lost fetuses and adults was that the mutations in the fetuses occurred in essential genomic sequences," says Hákon Jónsson scientist at deCODE genetics, and one of the authors on the paper.
Moreover, they managed to pinpoint when, in the development of the fetus, some of the mutations occurred.
In addition to mapping new mutations in the lost fetuses, they also showed that some couples are at a higher risk of pregnancy loss due to genetic compatibility issues. You inherit one copy of a gene from each parent, and most of the time, you are fine with one defective copy, but problems can arise if you inherit a defective copy from both parents.
"We have shown previously that for certain genes, you never observe two defective copies in adult genomes, but we found two defective copies in some of the pregnancy losses. Importantly, these involve a high risk for recurrence of pregnancy loss for the couple but can be selected against in IVF treatments," says Guðný A. Árnadóttir scientist at deCODE genetics, and one of the authors on the paper.
Along with recombination, the continuous generation of mutations enables us to evolve as a species. However, this continuous influx of new mutations comes at the expense of rare diseases. This study demonstrates the contribution of mutations to pregnancy loss and sheds new light on conserved sequences in the human genome.
Based in Reykjavik, Iceland, deCODE genetics is a global leader in analyzing and understanding the human genome. Using its unique expertise and population resources, deCODE has discovered genetic risk factors for dozens of common diseases. The purpose of understanding the genetics of disease is to use that information to create new means of diagnosing, treating and preventing disease. deCODE genetics is a wholly-owned subsidiary of Amgen.
** The press release content is from PR Newswire. Bastille Post is not involved in its creation. **
Lethal mutations in pregnancy loss
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PANAMA CITY, Dec. 25, 2025 /PRNewswire/ -- HTX, a leading global cryptocurrency exchange, has announced a comprehensive upgrade to HTX Earn, its premier digital asset wealth management suite. Alongside this upgrade, the exchange officially launched its flagship incentive campaign, the HTX Earn Carnival. The initiative features subsidized annualized yields of up to 15% APY across core assets, complemented by high-value physical rewards, including the latest Apple flagship product lineup.
The move comes as year-end market sentiment shows signs of recovery, with investors increasingly prioritizing lower-risk, yield-bearing products. The revamped HTX Earn interface boasts a simplified product structure, more efficient experience, and more competitive returns, aiming to provide a "one-stop" solution for digital asset appreciation.
Reap 15% APY on 27 Assets and Amazing Prizes
The HTX Earn Carnival event is scheduled to run from December 24, 2025, at 02:00 (UTC) through January 1, 2026, at 16:00:00 (UTC). During this period, HTX is offering significant APY subsidies for Flexible Earn products across 27 mainstream assets. Participants earn up to 15% APY on their idle assets through subscriptions.
Eligible assets include major stablecoins such as USDT, USDD, USD1, and USDC, alongside a broad range of core cryptocurrencies including BTC, ETH, TRX, ZEC, TURBO, NEO, WBT, APE, COMP, QTUM, PENDLE, DOT, TON, SOL, ATOM, CSPR, POL, NEAR, ADA, SUI, APT, A, and CRV. This diverse selection is designed to accommodate both conservative yield strategies and diversified portfolio needs.
The participation process is straightforward:
- Access: Users can log in their HTX accounts and find Earn on the navigation bar via the official HTX website or directly from the app homepage.
- Mechanics: Yield calculation rules are fully transparent. Users who reach specified net asset increase thresholds during the maintenance period will receive APY Booster Coupons for the USDT Flexible Earn product.
- Lucky Draws: In addition to the APY boosts, users ranked among the top contributors by net asset increase will be eligible for lucky draws to win Apple flagship devices, including the iPhone 17 Pro Max, Apple Watch Series 11, and AirPods Pro 3.
- The campaign follows a four-stage structure: Subscription, Asset Maintenance, Review, and Reward Claim. Users must complete registration and asset allocation during the subscription phase. Rewards are determined by the net asset increase maintained throughout the period and must be manually claimed during the designated window; unclaimed rewards will be forfeited.
HTX Earn Revamped: Five Core Modules
HTX has systematically upgraded the HTX Earn ecosystem, restructuring the interface into five clearly defined modules to enhance usability and long-term management efficiency:
- Overview: A unified dashboard to monitor asset allocation and yield performance.
- Simple Earn: Designed for conservative, straightforward yield strategies.
- New Listings: Dedicated to high-potential yields for newly onboarded tokens.
- Structured Products: For advanced investors seeking tailored opportunities.
- On-Chain Earn: Direct access to decentralized staking and PoS opportunities.
The refined categorization significantly reduces decision-making friction, allowing users to align their strategies precisely with their risk preferences. Furthermore, the redesigned homepage now features a dedicated promotions area for limited-time boosts and an intelligent recommendation module that suggests products based on a user's current asset structure. Additional optimizations include an SVIP zone, a newcomer section, and multi-dimensional filters for a tailored experience.
From Campaign Incentive to Sustainable Yield
From the launch of HTX Earn Carnival to the continued evolution of its Earn product architecture, HTX is reinforcing its commitment to long-term, sustainable asset appreciation, aiming to deliver professional, transparent, and efficient asset management tools beyond short-term promotions. Looking ahead, HTX plans to further expand its Earn offerings, refine user experience, and introduce diversified yield mechanisms aligned with real user demand.
About HTX
Founded in 2013, HTX (formerly Huobi) has evolved from a virtual asset exchange into a comprehensive ecosystem of blockchain businesses that span digital asset trading, financial derivatives, research, investments, incubation, and other businesses.
As a world-leading gateway to Web3, HTX harbors global capabilities that enable it to provide users with safe and reliable services. Adhering to the growth strategy of "Global Expansion, Thriving Ecosystem, Wealth Effect, Security & Compliance," HTX is dedicated to providing quality services and values to virtual asset enthusiasts worldwide.
To learn more about HTX, please visithttps://www.htx.com/ or HTX Square , and follow HTX on X, Telegram, and Discord.
PANAMA CITY, Dec. 25, 2025 /PRNewswire/ -- HTX, a leading global cryptocurrency exchange, has announced a comprehensive upgrade to HTX Earn, its premier digital asset wealth management suite. Alongside this upgrade, the exchange officially launched its flagship incentive campaign, the HTX Earn Carnival. The initiative features subsidized annualized yields of up to 15% APY across core assets, complemented by high-value physical rewards, including the latest Apple flagship product lineup.
The move comes as year-end market sentiment shows signs of recovery, with investors increasingly prioritizing lower-risk, yield-bearing products. The revamped HTX Earn interface boasts a simplified product structure, more efficient experience, and more competitive returns, aiming to provide a "one-stop" solution for digital asset appreciation.
Reap 15% APY on 27 Assets and Amazing Prizes
The HTX Earn Carnival event is scheduled to run from December 24, 2025, at 02:00 (UTC) through January 1, 2026, at 16:00:00 (UTC). During this period, HTX is offering significant APY subsidies for Flexible Earn products across 27 mainstream assets. Participants earn up to 15% APY on their idle assets through subscriptions.
Eligible assets include major stablecoins such as USDT, USDD, USD1, and USDC, alongside a broad range of core cryptocurrencies including BTC, ETH, TRX, ZEC, TURBO, NEO, WBT, APE, COMP, QTUM, PENDLE, DOT, TON, SOL, ATOM, CSPR, POL, NEAR, ADA, SUI, APT, A, and CRV. This diverse selection is designed to accommodate both conservative yield strategies and diversified portfolio needs.
The participation process is straightforward:
- Access: Users can log in their HTX accounts and find Earn on the navigation bar via the official HTX website or directly from the app homepage.
- Mechanics: Yield calculation rules are fully transparent. Users who reach specified net asset increase thresholds during the maintenance period will receive APY Booster Coupons for the USDT Flexible Earn product.
- Lucky Draws: In addition to the APY boosts, users ranked among the top contributors by net asset increase will be eligible for lucky draws to win Apple flagship devices, including the iPhone 17 Pro Max, Apple Watch Series 11, and AirPods Pro 3.
- The campaign follows a four-stage structure: Subscription, Asset Maintenance, Review, and Reward Claim. Users must complete registration and asset allocation during the subscription phase. Rewards are determined by the net asset increase maintained throughout the period and must be manually claimed during the designated window; unclaimed rewards will be forfeited.
HTX Earn Revamped: Five Core Modules
HTX has systematically upgraded the HTX Earn ecosystem, restructuring the interface into five clearly defined modules to enhance usability and long-term management efficiency:
The refined categorization significantly reduces decision-making friction, allowing users to align their strategies precisely with their risk preferences. Furthermore, the redesigned homepage now features a dedicated promotions area for limited-time boosts and an intelligent recommendation module that suggests products based on a user's current asset structure. Additional optimizations include an SVIP zone, a newcomer section, and multi-dimensional filters for a tailored experience.
From Campaign Incentive to Sustainable Yield
From the launch of HTX Earn Carnival to the continued evolution of its Earn product architecture, HTX is reinforcing its commitment to long-term, sustainable asset appreciation, aiming to deliver professional, transparent, and efficient asset management tools beyond short-term promotions. Looking ahead, HTX plans to further expand its Earn offerings, refine user experience, and introduce diversified yield mechanisms aligned with real user demand.
About HTX
Founded in 2013, HTX (formerly Huobi) has evolved from a virtual asset exchange into a comprehensive ecosystem of blockchain businesses that span digital asset trading, financial derivatives, research, investments, incubation, and other businesses.
As a world-leading gateway to Web3, HTX harbors global capabilities that enable it to provide users with safe and reliable services. Adhering to the growth strategy of "Global Expansion, Thriving Ecosystem, Wealth Effect, Security & Compliance," HTX is dedicated to providing quality services and values to virtual asset enthusiasts worldwide.
To learn more about HTX, please visithttps://www.htx.com/ or HTX Square , and follow HTX on X, Telegram, and Discord.
** The press release content is from PR Newswire. Bastille Post is not involved in its creation. **
HTX Earn Fully Upgraded: Join HTX Earn Carnival, Earn Up to 15% APY and Apple Product Rewards
