Dechra Announces FDA Approval of Zygolide® (pergolide tablets) for the Control of Clinical Signs Associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing’s Disease) in Horses

OVERLAND PARK, Kan.--(BUSINESS WIRE)--Jan 5, 2026--

Dechra, a global leader in veterinary specialty care, today announced the FDA approval of Zygolide ® (pergolide tablets), the first FDA-approved bioequivalent option indicated for the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (PPID) in horses.

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PPID, also known as Equine Cushing’s Disease, affects approximately 21% of horses aged 15 and older, and prevalence increases to 30% in horses over 30 years old 1. As the population of senior horses continues to grow, the need for more affordable treatment options has become increasingly important for both veterinarians and caretakers 2.

This approval expands access to an essential therapy for one of the most common endocrine disorders in aging horses. Zygolide ® offers an enhanced standard of care for patient experience through:

“The FDA approval of Zygolide ® brings to market a high-quality, cost-effective option to help make the management of PPID more accessible,” said Dr. Greg Schmid, Equine Medical Affairs Lead, Dechra. “This therapy provides another option for horses living with the condition, including a pill structure with 360-degree scoring on all sides and a peppermint flavor profile, helping to reduce stress for both horses and their caretakers.”

Availability

Zygolide ® (pergolide tablets) will be available through veterinarians beginning January 2026 and can be purchased with a prescription from major online pharmacies nationwide.

About Zygolide ®

Zygolide ® is indicated for the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (PPID) (Equine Cushing’s Disease) in horses.

Zygolide ® is administered orally.

Important Safety Information

As with all drugs, side effects may occur. Zygolide ® (pergolide tablets) is for use in horses only. Zygolide has not been evaluated in breeding, pregnant or lactating horses. Treatment with Zygolide may cause loss of appetite. Most cases are mild. If severe, a temporary dose reduction may be necessary. Weight loss, lack of energy, and behavioral changes also may be observed. Zygolide tablets should not be crushed due to the potential for increased human exposure. Pregnant or lactating women should wear gloves when administering this product. Zygolide is contraindicated in horses with hypersensitivity to pergolide mesylate or other ergot derivatives. Keep Zygolide in a secure location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose. Dogs have eaten Zygolide tablets that were placed in food intended for horses or dropped during administration of the tablets to the horses. Adverse reactions may occur if animals other than horses ingest Zygolide tablets. Refer to the prescribing information here for complete details or visit www.dechra‐us.com.

About Dechra

Dechra is a global specialist in veterinary pharmaceuticals and related products, dedicated to supporting veterinarians, pet owners, and the animals they care for. For more information, visit www.dechra-us.com.

This product is only available in the US at this time. This communication may contain information otherwise not accessible or valid in your country. Please be aware that we do not take any responsibility for you accessing such information that may not comply with any legal process, regulation, registration, or usage in the country of your origin.

References

Dechra is a registered trademark of Dechra Pharmaceuticals Limited. Zygolide ® is a registered trademark of Dechra Limited.

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Dechra Announces FDA Approval of Zygolide® (pergolide tablets) for the Control of Clinical Signs Associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing’s Disease) in Horses

WASHINGTON (AP) — The Trump administration is set to loosen a federal rule that requires grocery stores and air-conditioning companies to reduce greenhouse gases used in cooling equipment, in what officials say is a push to lower grocery costs.

The head of the Environmental Protection Agency, Lee Zeldin, said the Biden-era rule imposes costly restrictions that limit the type of refrigerants U.S. businesses and families can use.

The new rule will “allow businesses to choose the refrigeration systems that work best for them, saving them billions of dollars. This will be felt directly by American families in lower grocery prices,” Zeldin said in a statement released before a White House event Thursday where President Donald Trump is scheduled to announce the changes. Executives from Kroger, Piggly Wiggly and other grocery chains are expected to join him.

With voter concerns over the cost of living spiking before pivotal elections in November, the Republican administration is trying to address affordability issues. It is not clear how much or how quickly the loosening of the refrigerant rule might ease grocery prices.

Inflation in the United States increased to 3.8% annually in April, amid price spikes caused by the Iran war and President Donald Trump's sweeping tariffs. Inflation is now outpacing wage gains as the war has kept oil and gasoline prices high.

The administration's action on refrigerants represents a reversal after Trump signed a law in his first term that aimed to reduce harmful, planet-warming pollutants emitted by refrigerators and air conditioners. That bipartisan measure brought environmentalists and major business groups into rare alignment on the contentious issue of climate change and won praise across the political spectrum.

The 2020 law reflected a broad bipartisan consensus on the need to quickly phase out domestic use of hydrofluorocarbons, or HFCs, that are thousands of times more potent than carbon dioxide and are considered a major driver of global warming.

The EPA action highlights the second Trump administration’s drive to roll back regulations perceived as climate friendly. The plan is among a series of sweeping environmental changes that Zeldin has said will put a “dagger through the heart of climate change religion.”

Environmentalists have criticized the administration's plans, saying a proposed rule announced last year would exacerbate climate pollution while disrupting a yearslong industry transition to new coolants as an alternative to HFCs.

FILE - A shop owner reaches into a drink display refrigerator at his convenience store in Kent, Wash., Oct. 1, 2018. (AP Photo/Elaine Thompson, File)