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Bruker Announces Successful Installation of 1.2 GHz Avance® NMR Spectrometer at the Korea Basic Science Institute (KBSI)

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Bruker Announces Successful Installation of 1.2 GHz Avance® NMR Spectrometer at the Korea Basic Science Institute (KBSI)
News

News

Bruker Announces Successful Installation of 1.2 GHz Avance® NMR Spectrometer at the Korea Basic Science Institute (KBSI)

2024-08-14 01:35 Last Updated At:01:41

SEOUL, South Korea--(BUSINESS WIRE)--Aug 13, 2024--

Bruker Corporation is pleased to announce the successful installation and acceptance of a 1.2 GHz Avance® Nuclear Magnetic Resonance (NMR) spectrometer at the Korea Basic Science Institute ( KBSI ), just in time before the start of the ICMRBS 2024 conference in Korea. As the first 1.2 GHz NMR system in the Asia-Pacific region, it sets a new benchmark for molecular, cell biology and disease research by ultra-high field NMR.

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This underscores KBSI’s unwavering commitment to innovation in research infrastructure, cementing its status as a world-class fundamental research institute. This cutting-edge 1.2 GHz NMR spectrometer further enhances KBSI’s capabilities in biomolecular structure analysis and drug development, pushing the boundaries of protein NMR research. Ultra-high field NMR provides excellent sensitivity and unprecedented resolution, enabling researchers to observe functional molecular dynamics and structural rearrangements in real time. Complementary to other structural biology technologies, GHz-class NMR allows KBSI to elucidate complex biological processes, such as protein-ligand interactions and the behavior of intrinsically disordered proteins, which are crucial for understanding disease mechanisms and developing new therapeutic strategies.

Dr. Hae-Kap Cheong, Manager of the UHF NMR system at KBSI, expressed his enthusiasm: “When using the 1.2 GHz instrument, the opportunities for small molecule research made me speechless. In particular, the structural elucidation of natural products will be greatly beneficial.”

Dr. Donghan Lee, Scientific Researcher at KBSI, adds: “As Richard Feynman said, ‘Everything that living things do can be understood in terms of the jiggling and wiggling of atoms.’ The function of biomolecules can be understood by their dynamic nature. In particular, the functional conformation of biomolecules may be hidden because of their dynamic nature. With the 1.2 GHz instrument, the detection of these conformations enables the unprecedented identification of functional conformations.”

KBSI is dedicated to advancing scientific research through state-of-the-art technology and innovative research facilities. As a platform for global basic research, KBSI connects research facilities, equipment, and researchers, driving the future of science and technology in the Asia-Pacific region. With its mission to lead the innovation of research facilities and equipment, KBSI continues to support advanced analytical research and joint research initiatives in Korea and beyond.

Dr. Kyoung-Seok Ryu, Director of the Biopharmaceutical Research Center at KBSI, added: “The application of the 1.2 GHz instrument includes mechanistic understanding, in particular, the mode-of-action of drug-target binding and molecular communication. Furthermore, studying intrinsically disordered or partially disordered proteins with the 1.2 GHz NMR instrument can elucidate the functional mechanisms underlying neurodegeneration.”

KBSI will utilize the 1.2 GHz spectrometer for a diverse range of research applications, including the study of biomolecular structures and the development of new drugs. This ultra-high field NMR instrument will support other KBSI research in biomedical multiomics, bioimaging, and the development of diagnostic methods for infectious diseases. The broader benefits of this research will extend to advancements in medical research, materials science, and other critical fields.

Dr. Falko Busse, President of Bruker BioSpin, commented: “We are thrilled to see the 1.2 GHz NMR become a key part of KBSI’s research infrastructure. Grateful for the trust from KBSI, we look forward to the scientific advancements that will emerge. We are pleased to offer a tour of the 1.2 GHz NMR at KBSI during the International Conference on Magnetic Resonance in Biological Systems.”

Interested researchers can book the tour at Bruker Booth A1 at ICMRBS for Friday, August 23, providing a unique opportunity to explore the advanced capabilities of this revolutionary instrument.

With the installation at KBSI, there are now 22 GHz-class NMR spectrometers installed worldwide, including two in the Asia-Pacific region. This demonstrates the growing recognition of the value GHz-class NMR brings to scientific research. Together with the first single-story 1.0 GHz NMR already installed in Japan, KBSI’s 1.2 GHz highlights the need for cutting-edge research infrastructure.

About Bruker Corporation – Leader of the Post-Genomic Era (Nasdaq: BRKR)

Bruker is enabling scientists and engineers to make breakthrough post-genomic discoveries and develop new applications that improve the quality of human life. Bruker’s high performance scientific instruments and high value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular, and microscopic levels. In close cooperation with our customers, Bruker is enabling innovation, improved productivity, and customer success in post-genomic life science molecular and cell biology research, in applied and biopharma applications, in microscopy and nanoanalysis, as well as in industrial and cleantech research, and next-gen semiconductor metrology in support of AI. Bruker offers differentiated, high-value life science and diagnostics systems and solutions in preclinical imaging, clinical phenomics research, proteomics and multiomics, spatial and single-cell biology, functional structural and condensate biology, as well as in clinical microbiology and molecular diagnostics. For more information, please visit www.bruker.com.

Dr. Kyoung-Seok Ryu, Director of Biopharmaceutical Research Center, KBSI

Dr. Kyoung-Seok Ryu, Director of Biopharmaceutical Research Center, KBSI

1.2 GHz Avance® NMR system at Korea Basic Science Institute (KBSI)

1.2 GHz Avance® NMR system at Korea Basic Science Institute (KBSI)

SAN ANTONIO (AP) — Two All-Americans, one chance to get their team a chance to win a national championship.

And more magic from Florida's Walter Clayton Jr. will carry the Gators to their title shot.

Clayton scored 34 points to outduel Auburn's Johni Broome as the Gators beat the Tigers 79-73 on Saturday night at the Final Four.

And while it wasn't a direct matchup between small and ultra-quick Clayton and the beefy Broome, those two have been the heartbeat of their teams in the NCAA Tournament.

Clayton was virtually unstoppable again, as he scored at least 30 points for the second consecutive game, slicing through the Tigers defense for layups or popping 3-pointers even with defenders in his face.

“The guys trust me to take those shots and sometimes they fall," Clayton said.

Clayton was 11 of 18 from the field, making 5 of 8 3-point attempts. He made all seven free throws.

As the final seconds ticked down, Clayton even chased a loose ball to tip it back to ensure the clock would run out on the victory. When he started to walk back on the court, teammate Alijah Martin was standing watching him with a smile before they hugged with win in hand.

“He has done it all year for us, in big moments,” Florida coach Todd Golden said.

Broome, started well with 12 points in the first half as he used his size and strength to muscle over defenders under the basket.

But while he had insisted that a right elbow injured in the South Region final win over Michigan State was pain-free, he appeared to favor it at times and often looked uncomfortable.

He also looked frustrated by late turnovers and missed free throws as the game started slipping away. Broome scored just three points on just four shots in the second half and finished with 15 points and seven rebounds.

Broome frustration showed late when he lowered his shoulder into Florida's Alex Condon and was called for a foul. He was later denied a dunk, and then missed two free throws with 2:02 to play that would have cut the Gators' lead to 71-70.

AP March Madness bracket: https://apnews.com/hub/ncaa-mens-bracket and coverage: https://apnews.com/hub/march-madness. Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here.

Auburn's Johni Broome (4) shoots as Florida's Alex Condon (21) defends during the second half in the national semifinals at the Final Four of the NCAA college basketball tournament, Saturday, April 5, 2025, in San Antonio. (AP Photo/Eric Gay)

Auburn's Johni Broome (4) shoots as Florida's Alex Condon (21) defends during the second half in the national semifinals at the Final Four of the NCAA college basketball tournament, Saturday, April 5, 2025, in San Antonio. (AP Photo/Eric Gay)

Auburn forward Johni Broome vies for the ball with Florida guard Alijah Martin during the second half in the national semifinals at the Final Four of the NCAA college basketball tournament, Saturday, April 5, 2025, in San Antonio. (AP Photo/Brynn Anderson)

Auburn forward Johni Broome vies for the ball with Florida guard Alijah Martin during the second half in the national semifinals at the Final Four of the NCAA college basketball tournament, Saturday, April 5, 2025, in San Antonio. (AP Photo/Brynn Anderson)

Florida's Walter Clayton Jr. (1) goes up for a shot as Auburn's Johni Broome defends during the second half in the national semifinals at the Final Four of the NCAA college basketball tournament, Saturday, April 5, 2025, in San Antonio. (AP Photo/Eric Gay)

Florida's Walter Clayton Jr. (1) goes up for a shot as Auburn's Johni Broome defends during the second half in the national semifinals at the Final Four of the NCAA college basketball tournament, Saturday, April 5, 2025, in San Antonio. (AP Photo/Eric Gay)

Auburn's Johni Broome (4) and Florida's Alex Condon (21) react after a play during the second half in the national semifinals at the Final Four of the NCAA college basketball tournament, Saturday, April 5, 2025, in San Antonio. (AP Photo/Stephanie Scarbrough)

Auburn's Johni Broome (4) and Florida's Alex Condon (21) react after a play during the second half in the national semifinals at the Final Four of the NCAA college basketball tournament, Saturday, April 5, 2025, in San Antonio. (AP Photo/Stephanie Scarbrough)

Auburn guard Chad Baker-Mazara vies for the ball with Florida guard Walter Clayton Jr. during the first half in the national semifinals at the Final Four of the NCAA college basketball tournament, Saturday, April 5, 2025, in San Antonio. (AP Photo/Brynn Anderson)

Auburn guard Chad Baker-Mazara vies for the ball with Florida guard Walter Clayton Jr. during the first half in the national semifinals at the Final Four of the NCAA college basketball tournament, Saturday, April 5, 2025, in San Antonio. (AP Photo/Brynn Anderson)

Florida guard Walter Clayton Jr. celebrates after scoring against Auburn during the first half in the national semifinals at the Final Four of the NCAA college basketball tournament, Saturday, April 5, 2025, in San Antonio. (AP Photo/Brynn Anderson)

Florida guard Walter Clayton Jr. celebrates after scoring against Auburn during the first half in the national semifinals at the Final Four of the NCAA college basketball tournament, Saturday, April 5, 2025, in San Antonio. (AP Photo/Brynn Anderson)

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