Chinese scientists have reported findings recently in their latest experiments aboard the Tiangong space station: while brain cells migrates faster, muscle repair process is more slowly, and medicines for lipid metabolism disorders show a pronounced boost in potency in weightless environment.
The discoveries could reshape approaches to Alzheimer's therapy, muscle-atrophy prevention and next-generation drug research and development.
"Currently, our in-orbit observations show that neurons in organ-on-a-chip move faster in space than on the ground. This may indicate that the unique environment of space promotes cell movement in our brain tissue," said Jin Xuena, principal designer of life sciences of the Space Application Engineering and Technology Center under the Chinese Academy of Sciences.
A parallel experiment tracking skeletal-muscle precursor cells shows the opposite trend.
In the weightless environment, the cells' migration rate drops sharply and the overall timeline for muscle regeneration is delayed.
The finding underscores the difficulty of repairing damaged muscle in space.
A third study examined how lipid-nanoparticles ferry nucleic-acid drugs into cells.
On-orbit data reveal that cellular uptake of the drug is markedly higher in microgravity, and levels of disease-related proteins decline more rapidly.
"In a space environment, the therapeutic effects of drugs for lipid metabolism disorders are significantly enhanced. Therefore, the microgravity environment in space may serve as a new approach for future drug intervention or drug development," said Jin.
Experiments in China's space station create new path for treating brain disorders
